| 唐玲燕,王洁,喻荣彬,苏静,许可,彭志行,邓小昭,丁伟良,葛志军,张云.IL-10基因多态性与江苏地区高危人群丙型肝炎病毒感染转归的关联研究[J].Chinese journal of Epidemiology,2012,33(9):898-902 |
| IL-10基因多态性与江苏地区高危人群丙型肝炎病毒感染转归的关联研究 |
| Association between IL-10 gene polymorphisms and the outcomes of hepatitis C virus infection among high-risk populations in Jiangsu province |
| Received:May 10, 2012 |
| DOI：10.3760/cma.j.issn.0254-6450.2012.09.005 |
| KeyWord: 丙型肝炎 白细胞介素-10 基因多态性 |
| English Key Word: Hepatitis C Interleukin-10 Gene polymorphism |
| FundProject:国家自然科学基金(81072343)；江苏省自然科学基金(sbk201120309) |
| Author Name | Affiliation | E-mail | | Tang Ling-yan | Department of Epidemiology and Bioaatistics, Nanjing Medical University, Nanjing 210029, China | | | Wang Jie | Department of Epidemiology and Bioaatistics, Nanjing Medical University, Nanjing 210029, China | wangjie_wj77@yahoo.com.cn | | Yu Rong-bin | Department of Epidemiology and Bioaatistics, Nanjing Medical University, Nanjing 210029, China | | | Su Jing | Department of Epidemiology and Bioaatistics, Nanjing Medical University, Nanjing 210029, China | | | Xu Ke | Jiangsu Provincial Center for Disease Control and Preveatlon | | | Peng Zhi-hang | Department of Epidemiology and Bioaatistics, Nanjing Medical University, Nanjing 210029, China | | | Deng Xiao-zhao | Department of Epidemiology and Bioaatistics, Nanjing Medical University, Nanjing 210029
Medical Institute of Nanjing Army | | | Ding Wei-liang | Yixing People's Hospital | | | Ge Zhi-jun | Yixing People's Hospital | | | Zhang Yun | Medical Institute of Nanjing Army | zhangyunll1@sohu.comw |
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| Abstract: |
| 目的 探讨江苏地区高危人群IL-10基因多态性与丙型肝炎病毒(HCV)感染转归的关系。方法 运用Taqman-MGB技术检测264例HCV自限感染者、37l例HCV持续感染者和920例对照者的IL-10-819T/C、-592A/C、-1082A/G位点基因多态性。结果 调整性别、年龄和高危人群种类混杂因素后，logistic回归分析显示3个位点的基因多态性分别与HCV感染转归无显著关联(P值均>0 05)。进一步分层分析显示，-819T/C位点中，TC基因型使中年人、女性和有偿献血人群HCV自限感染的机会增加[调整OR值及其95%C1分别为2160(1.163～4.011)、1.693(1.066～2.688)和4.084(1.743～9.570)]，在有偿献血人群中使个体进展为持续感染的风险降低(凋整OR=0.312, 95%C1: 0.130～0.747)；CC基因型使血液透析人群HCV自限感染的机会增加(调整OR=2.120．95%C1: 1.071～4.197)，同时在有偿献血人群中使个体进展为持续感染的风险降低(调整OR=0.156，95%C1: 0.043～0.566)。-592A/C位点中，AC基因型使中年人、女性和有偿献血人群HCV自限感染的机会显著增加[调整OR值及其95%Cl分别为2.176(1.173～4.037)、1.659(1.055～2.607)和3.704(1.625～8.443)]，在女性中增加了HCV持续感染的风险(调整OR=1.525，95%C1：1.017～2.286)，在吸毒人群中使个体进展为持续感染的风险增加(调整OR=1.845和95%C1: 1.122～3.034)，而在有偿献血人群中使个体进展为持续感染的风险降低(调整OR=0.361, 95%Cl: 0.155～0.841)。CC基因型增加了有偿献血人群HCV自限感染的机会，同时也使个体进展为持续感染的风险降低[调整OR值及其95%C1分别为3.125(1.016～9.605)和0.218(0.063～0.748)]。-1082A/G位点中，突变基因型AG/GG能增加有偿献血人群HCV自限感染的机会(调整OR=3.780, 95%Cl: 1.620～8.820)。结论 IL-10-819T/C、-592A/C、-1082A/G三个位点的基因多态性存不同高危人群中与HCV感染转归可能有一定关联。 |
| English Abstract: |
| Objective To explore the relationship between interleukin (IL)-10 gene polymorphisms and the susceptibility or the outcomes of HCV infection among high-risk populations in Jiangsu province Methotis IL-10 gene SNPs were detected in 1555 subjects including 264 self-limited HCV infections. 371 persistent HCV infections and 920 healthy controls were selected through Taqman-MGB. Results After adjusted for cofounders as sex, age and high-risk population, data from logistic regrcssion analysis showed that the distribution of IL-10 genotypes among the controls, spontaneous clearances and those with persistent infections did not show much differences. Results from further stratified analysis showed that, at the position of -819T/C, when compared with TT genotype, TC genotype had a significantly increasing chance of self-limited HCV infection among middle-aged, females and paid blood doners (adjusted OR values and 95% C1 were: 2.160, 1.163-4.011; l.693, 1.066-2.688 and 4.084, 1.743-9.570). It also had a lower risk of progressing to persistent HCV infection among those paid blood doners(the adjusted OR values and 95%C1 were: 0.312, 0.130-0.747). CC genotype had a higher chance of self-limited HCV infecfion among people underwent blood dialysis(the adjusted OR values and 95%Cl were: 2.120, 1.07l-4.197). Results also showed a decreased risk of progressing to persistent infection among paid blood doners(the adjusted OR values and 95%C1 were: 0.156, 0.043-0.566). At the position of -592A/C, when compared to AA genotypc, the AC genotype had a significantly increasing chance of self-limited HCV infection among middle-aged, females and paid blood doners(the adjusted 0R values and 95%C1 were: 2.176, 1.173-4.037; l.659, l.055-2.607; 3.704, 1.625-8.443) but had an increased risk of persistent HCV infection among females (the adjusted 0R values and 95%C1 were: 1.525, 1.017-2.286). AC genotype showed an increased opportunity to progress to HCV persistent infection among drug users (the adjusted OR values and 95%C1 were: 1.845, 1.122-3.034) but had a reduced risk of progressing to HCV persistent infection among paid blood doners (the adjusted OR values and 95%C1 were: 0.36l, 0.155-0.841) CC genotype had an increased opportunity to self-limited HCV infection as well as having a decreased risk of progressing to persistent infection among paid blood doners (the adjusted OR values and 95%C1 were: 3.125, 1.016-9.605; 0.218, 0.063-0.748). At the position of -1082A/G, AG/GG genotypcs had an increased chance of self-limited infection among blood doners (the adjusted OR values and 95%C1 were: 3.780, 1.620-8.820)．Condusion IL-10-819T/C, -592A/C, -1082A/G SNPs might be related with the susceptibility and the outcomes of HCV infection among populationsat high risk． |
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