| 王国平,韩小友,丁悌,苏文,李建民,高泽锋.山西省贲门癌患者血缘亲属患病风险比较研究[J].Chinese journal of Epidemiology,2012,33(11):1123-1126 |
| 山西省贲门癌患者血缘亲属患病风险比较研究 |
| Studies on the risks of cardia neoplasm among immediate relatives of the patients in Shanxi province |
| Received:April 13, 2012 |
| DOI：10.3760/cma.j.issn.0254-6450.2012.11.005 |
| KeyWord: 贲门肿瘤 一级亲属关系 相对危险度 |
| English Key Word: Cardia neoplasms 1st grade kinship Relative risk |
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| Abstract: |
| 目的 对比分析贲门癌病例组与对照组血缘亲属患病风险，了解家族中危险亲属人群患贲门癌的新线索.方法 采用病例对照方法，对贲门癌病例组和对照组各772例进行逐层分析，比较两组各血缘亲属父系、母系贲门癌患病相对危险度(RR)及差异.结果 (1)合计和男性病例组一级亲属贲门癌患病危险显著高于对照组(RR=2.61，95％CI:1.44～ 4.73，P＜0.01).(2)以父系和母系亲属逐层分析，合计和男性病例组父系亲属贲门癌患病危险显著高于对照组(P＜0.05)，母系亲属中男性贲门癌患病危险显著高于对照组(P＜0.05)；进一步分析显示，合计和男性病例组中父系亲属中男性、母系亲属中女性贲门癌患病危险显著高于对照组(P＜0.05).(3)贲门癌患者一级亲属患贲门癌危险度显著高于对照组(P＜0.05).(4)贲门癌患者父系亲属与对照组患病危险的差异无统计学意义(P＞0.05)，贲门癌患者母系亲属患病危险显著高于对照组(P＜0.05).结论 山西省贲门癌患者血缘亲属中贲门癌发病危险人群主要是一级亲属，应对此高风险人群开展防癌知识普及和筛查. |
| English Abstract: |
| Objective To analyze the different risks of cardia neoplasms in the immediate relatives of the cardia cancer patients, through a case-control study. Methods A case-control study was adopted on 772 cases and 772 controls, and relative risk (RR) were measured to compare the Results from patemal or matrilineal groups. Results (1)Risk of the 1st grade kinship to the male cardia-cancer-patient group was obviously higher than that of the control group with RR=2.61 (95％CI:1.44-4.73, P＜0.01). (2) The risks of both paternal (P＜0.05) and matrilineal (P＜0.05) in the male cardia-cancer-patients were obviously higher than that of the control groups while the risk of those male cardia-cancer-patients in the paternal was higher than that of the control group (P＜0.05), so as the case for female patients in the matrilineal group (P＜0.05). (3) Data from the 1st grade kinship of cardia-cancer-patient group showed that parents and siblings had a higher risk than the control group (P＜0.05). (4) No significant genetic differences were found between the patemal of either the cancer group or the control group (P＞ 0.05), but statistical difference was observed that the risk of someone being the matrilineal of the cancer group was higher than that of the control group (P＜0.05). Conclusion The risks of cardia-cancer were higher in the 1st grade kinship, which including parents, brothers, sisters, maternal grandmother, mother, and maternal aunt. It was suggested that prevention programs should be focused on both earlier detection and treatment of the patients. New strategy for cancer prevention also need to be further developed. |
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