中国部分地区HIV阳性男男性行为者合并HCV感染状况及其自然清除率调查

安明晖; 韩晓旭; 刘静; 吴昊; 陈曦; 陆林; 徐俊杰; 张旻; 尚红

Abstract

安明晖,韩晓旭,刘静,吴昊,陈曦,陆林,徐俊杰,张旻,尚红.中国部分地区HIV阳性男男性行为者合并HCV感染状况及其自然清除率调查[J].Chinese journal of Epidemiology,2013,34(1):15-18

中国部分地区HIV阳性男男性行为者合并HCV感染状况及其自然清除率调查

Study on the rates of infection and spontaneous cleearance on HCV among HIV-infected men who have sex with men in China

Received:July 26, 2012

DOI：10.3760/cma.j.issn.0254-6450.2013.01.004

KeyWord: 男男性行为者艾滋病病毒丙型肝炎病毒混合感染

English Key Word: Men who have sex with men Human imunodeficiency virus Hepatitis C virus Co-infection

FundProject:国家科技重大专项(2012zx 10001-006 );国家临床重点专科建设项目卫生部重点实验室项目;辽宁省医学高峰建设工程专项经费项目([2010]696号2010001)

Author Name	Affiliation	E-mail
An Ming-hui	Key Laboratory of AIDS Immunology First Hospital of Ghina Medical Univers 110001，China
Han Xiao-xu	Key Laboratory of AIDS Immunology First Hospital of Ghina Medical Univers 110001，China
Liu Jing	Key Laboratory of AIDS Immunology First Hospital of Ghina Medical Univers 110001，China
Wu Hao	STD/AIDS Research Center, Beijing Youan Hospital,Capital Medical University
Cheng Xi	Hunan Provincial Center for Disease Control and Prevention
Lu Lin	Yunnan Provincial Center for Disease Control and Prevention
Xu Jun-jie	Key Laboratory of AIDS Immunology First Hospital of Ghina Medical Univers 110001，China
Zhang Min	Key Laboratory of AIDS Immunology First Hospital of Ghina Medical Univers 110001，China
Shang Hong	Key Laboratory of AIDS Immunology First Hospital of Ghina Medical Univers 110001，China	hongshang100@hotmail.com

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Abstract:

目的分析中国部分城市HIV阳性男男性行为者(MSM)中丙型肝炎病毒(HCV)感染状况及自然清除能力。方法以沈阳、北京、长沙和昆明市HIV确证阳性的MSM为研究对象，收集基本人口学资料及CD₄⁺T细胞淋巴细胞计数、HIV病毒载量、肝脏相关生化指标等临床信息，并进行HCV抗体和HCV RNA检测，并将HCV抗体阳性标本分为病毒自然清除(RNA-/Ab+)和慢性感染(RNA+/Ab+)两种感染状态。结果在513例HIV阳性MSM中，检出HCV抗体阳性10例(阳性率为1.94% )，其中4例HCV RNA阳性(阳性率为0.77% )，除1例HCV感染者正在接受抗病毒治疗HCV核酸检测阴性外，共5例感染者能够自然清除HCV RNAo HCV自然清除者相对于慢性感染(病毒血症)者具有较低的氨基转移酶水平和较高CD₄⁺T细胞淋巴细胞水平。结论目前调查地区HIV阳性的MSM中HCV感染率处于较低水平，但仍需定期监测。

English Abstract:

Objective The aim of this study was to understand the rates of infection and spontaneous clearance on hepatitis C virus (HCV) among HIV infected men who have sex with men (MSM) in China. Methods HIV-infected MSM from Shenyang, Beijing, Changsha and Kunmingwere selected to take the HCV antibody and HCV RNA tests, and then classified into ⁴under recovery (RNA-/Ab+)’or being chronic (RNA+/Ab+).Information on demography, CD₄⁺T cell, HIV viral load and liver biochemical indicators were also collected. Results In 513 HIV infected MSM,the positive rate of HCV antibody was 1.94% (10/513 ) and the positive rate of HCV RNA was 0.77%(4/513 ). Five patients showed clearance of HCV RNA, spontaneously. These 5 patients had low levels of both alanine transaminase (ALT) and aspartate aminotransferase (AST)，and with high level of CD₄⁺T cells, when compared to those who were not able to clear the HCV RNA. ConclusionCurrently, the HCV infection rate was still at quite low level among the HIV infected MSM in China.Dynamic of HIV/HCV co-infection should be monitored so as to develop suitable strategy onprevention and treatment among this population, in China.

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