糖尿病肾病发病的相关因素分析

邵海琳; 宋春青; 徐东红; 尚晓静; 郝兆虎

Abstract

邵海琳,宋春青,徐东红,尚晓静,郝兆虎.糖尿病肾病发病的相关因素分析[J].Chinese journal of Epidemiology,2013,34(4):393-395

糖尿病肾病发病的相关因素分析

Analyses on the relative factors regarding diabetic nephropathy

Received:November 19, 2012

DOI：

KeyWord: 糖尿病肾病相关因素高尿酸

English Key Word: Diabetic nephropathy Relevant factors Hyperuricemia

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Author Name	Affiliation	E-mail
SHAO Hai-lin	Department of Endocrinology of Tianjin Fourth Central Hospital．Tianjin 300140．China
SONG Chun-qing	Department of Endocrinology of Tianjin Fourth Central Hospital．Tianjin 300140．China	scql985@yahoo.corn.ca
XU Dong-hong	Department of Endocrinology of Tianjin Fourth Central Hospital．Tianjin 300140．China
SHANG Xiao-jing	Department of Endocrinology of Tianjin Fourth Central Hospital．Tianjin 300140．China
HAO Zhao-hu	Department of Endocrinology of Tianjin Fourth Central Hospital．Tianjin 300140．China

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Abstract:

目的 <\b>探讨糖尿病肾病(DN)发病的相关因素.方法 <\b>选取2009-2011年天津市第四中心医院住院治疗756例2型糖尿病患者,按尿微量白蛋白排泄率(UAER)分为三组,即＜20μg/min为无DN组(A组),20 μg/min＜UAER＜200 μg/min为微量DN组(B组),≥200 μg/min为大量DN组(C组).记录患者的一般资料,检测实验室指标,用多因素logistic回归分析DN的相关因素.结果 <\b>756例2型糖尿病患者中DN患者(B组和C组)228例,患病率为30.2％.DN患者年龄、病程、DBP和SBP均显著高于无DN组(A组)(P＜0.05)；大量DN组(C组)年龄、病程、DBP和SBP分别为(64.08±11.71)岁、(14.67±7.34)年、(87.43±14.36)mm Hg、(152.45±18.48)mmHg,与微量DN组(B组)对比,差异均有统计学意义(P＜0.05)；B组空腹血糖(FPG)、TG、TC、HDL-C、尿酸(UA)、糖化血红蛋白(HbAlc)、空腹胰岛素(FINS)、空腹C肽(FCP)分别为(9.27±3.06)mmol/L、(1.98±0.37) mmol/L、(5.01±1.08) mmol/L、(1.05±0.35) mmol/L、(312.78±39.83)mmol/L、(9.33±1.47)％、(11.45±7.83) μU/ml、(509.73±132.78) pmol/L,与A组对比,差异均有统计学意义(P＜0.05)；大量DN组(C组)FPG、TG、HDL-C、UA、FINS、FCP分别为(9.29±3.12)mmol/L、(2.02±0.36) mmol/L、(1.04±0.27) mmol/L、(389.72±46.32) mmol/L、(11.09±8.29)μU/ml、(575.77±143.29) pmol/L,与A组对比,差异均有统计学意义(P＜0.05)；大量DN组(C组)与微量DN组(B组)对比,UA、FINS、FCP的差异均有统计学意义(P＜0.05).多因素logistic回归分析表明,病程、BMI、SBP、HbAlc、FPG、UA与DN的发生有关.结论 <\b>DN的发生与病程、年龄及血糖、血脂、血压、尿酸水平密切相关.

English Abstract:

Objective <\b>To analyze the related factors regarding diabetic nephropathy (DN).Methods <\b>A total number of 756 diabetic patients from 2009 to 2011 were analyzed retrospectively.Three groups were formed according to the urinary albumin excretion rates (UAER).Patients with UAER＜20 μg/min was grouped to group A,with UAER from 20 to 200 μg/min as group B,and the others with UAER ≥200 μg/min was grouped to group C.General characteristics and laboratory parameters were then compared and related factors of DN analyzed.Results <\b>The constituent ratio of nephropathy was 30.2％ (228/756).Patient's age,duration of disease,both diastolic and systolic blood pressure of group A were significantly higher than the non-DN group (A) (P＜0.05).Patient's age,disease duration,both diastolic and systolic blood pressure of group C were (64.08± 11.71)years,(14.67± 7.34)years,(87.43 ± 14.36)mm Hg,(152.45 ± 18.48)mm Hg,respectively,with statistically significant difference (P＜0.05) between group C and group B.FPG,TG,TC,HDL-C,UA,HbAlc,FINS,FCP of group B were (9.27 ± 3.06) mmol/L,(1.98 ± 0.37) mmol/L,(5.01 ± 1.08) mmol/L,(1.05 ± 0.35) mmol/L,(312.78 ± 39.83) mmol/L,(9.33 ± 1.47)％,(11.45 ± 7.83) μU/ml,(509.73 ±132.78) pmol/L respectively,with significant difference (P＜0.05) between group B and group A.FPG,TG,HDL-C,UA,FINS,FCP of group C were (9.29 ± 3.12)mmol/L,(2.02 ± 0.36)mmol/L,(1.04 ± 0.27) mmol/L,(389.72 ± 46.32) mmol/L,(11.09 ± 8.29) μ U/ml,(575.77 ± 143.29) pmol/Lrespectively,with significant difference (P＜0.05) between group C and group A.UA,FINS,FCP were found with significant differences (P＜0.05) between group C and group B.Data from multivariate logistic regression showed that DNs were related with disease duration,BMI,systolic blood pressure,HbAlc,FPG,UA.Conclusion <\b>DN was closely related to the duration,age,blood sugar,blood lipids,blood pressure,uric acid levels of the disease.

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