甘肃省202株鼠疫耶尔森菌基因型分布及流行特征分析

王新华; 张宏; 郭丽民; 苗克军; 达文平; 吴斌; 徐大琴; 葛亚俊; 穆洮霞; 陈国娟; 周晓艳; 王世明; 格鹏飞; 席进孝

Abstract

王新华,张宏,郭丽民,苗克军,达文平,吴斌,徐大琴,葛亚俊,穆洮霞,陈国娟,周晓艳,王世明,格鹏飞,席进孝.甘肃省202株鼠疫耶尔森菌基因型分布及流行特征分析[J].Chinese journal of Epidemiology,2013,34(5):433-437

甘肃省202株鼠疫耶尔森菌基因型分布及流行特征分析

Analysis on genotype distributions and epidemiological characteristics of Yersinia pestis plague fociInGansu province

Received:November 21, 2012

DOI：10.3760/cmaj.issn.0254-6450.2014.02.005

KeyWord: 鼠疫耶尔森菌基因分型流行特征

English Key Word: rsiniapestis Genotyping Epidemiological characteristics

FundProject:国家卫生行业科研专项(201202012);甘肃省卫生行业计划项目(gswst09—14);甘肃省卫生行业管理项目(GWGL2010—33)

Author Name	Affiliation	E-mail
WANG Xinhua	Gansu Provinciat Centre for Disease Control and Preyention．Lanzhou 730000, China
ZHANG Hong	Gansu Provinciat Centre for Disease Control and Preyention．Lanzhou 730000, China
GUO Limin	Gansu Provinciat Centre for Disease Control and Preyention．Lanzhou 730000, China
MIAO kejun	Gansu Provinciat Centre for Disease Control and Preyention．Lanzhou 730000, China
DA Wenping	Gansu Provinciat Centre for Disease Control and Preyention．Lanzhou 730000, China
WU Bin	Gansu Provinciat Centre for Disease Control and Preyention．Lanzhou 730000, China
XU Daqin	Gansu Provinciat Centre for Disease Control and Preyention．Lanzhou 730000, China
GE Yajun	Gansu Provinciat Centre for Disease Control and Preyention．Lanzhou 730000, China
MU Taoxia	Gansu Provinciat Centre for Disease Control and Preyention．Lanzhou 730000, China
CHEN Guojuan	Gansu Provinciat Centre for Disease Control and Preyention．Lanzhou 730000, China
ZHOU Xiaoyan	Gansu Provinciat Centre for Disease Control and Preyention．Lanzhou 730000, China
WANG Shiming	Gansu Provinciat Centre for Disease Control and Preyention．Lanzhou 730000, China
GE Pengfei	Gansu Provinciat Centre for Disease Control and Preyention．Lanzhou 730000, China
Xi Jinxiao	Gansu Provinciat Centre for Disease Control and Preyention．Lanzhou 730000, China	xixxp@163．Tom

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Abstract:

目的研究甘肃省鼠疫耶尔森菌(鼠疫菌)基因分型分布及其流行特征。方法根据鼠疫菌基因组23个差异区段设计引物，采用PCR技术，分析甘肃省202株不同来源的鼠疫菌。结果202株鼠疫菌共分为8个基因型，即1b、5、7、8、13、26、GSl型(新基因型)和GS2型(新基因型)。自20世纪60年代起至今分离到1b、8和GSl基因型，而自1977年后再未分离到7、13、26基因型，在1995年后才分离到GS2、5基因型。结论
甘肃省lb、8和GSl基因型鼠疫菌自20世纪60年代起持续流行至今，7、13和26基因型菌已有40余年未分离到，而GS2和5基因型菌自20世纪90年代才开始流行。

English Abstract:

0bjective To study the genotype distributions and epidemiological characteristics of Yersinia pestis in Gansu province．Methods Primers were designed according to the confirmed 23 differential sections，to genotype the 202 Yersinia pestis DNA of Gansn province by PCR，and to analyze its distribution and epidemiological characteristics．ResultsYersinia pestis in Gansu province could be divided into eight genotypes：lb，5，7，8，13，26，new genotype 1(GSl)and new genotype 2(GS2)．They were distributed in various regions．1b，8 and GSl genotypes of Yersinia pestis had been identified since 1 960s but the 7．1 3 and 26 genotypes had not been isolated for more than 40 years while GS2 and 5 genotypes had been isolated since 1990s．Conclusion lb，8 and GS 1 genotypes of Yersinia pestis continued to be violently prevalent since l 960s but 7．1 3 and 26 genotypes had not been isolated for more than 40 years while GS2 and 5 genotypes had started to be popular since 1 990s．

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