尿酸与冠状动脉钙化:北京社区自然人群横断面调查

曹慧丽; 吕滨; 陈雄彪; 鲁锦国; 侯志辉; 唐翔; 高扬; YU Fang-fang; 于方方; 陈阳; 蒋世良; 赵连成; 李莹; 顾东风

Abstract

曹慧丽,吕滨,陈雄彪,鲁锦国,侯志辉,唐翔,高扬,YU Fang-fang,于方方,陈阳,蒋世良,赵连成,李莹,顾东风.尿酸与冠状动脉钙化:北京社区自然人群横断面调查[J].Chinese journal of Epidemiology,2013,34(6):566-568

尿酸与冠状动脉钙化:北京社区自然人群横断面调查

Relation between uric acid and coronary artery calcification: a community-based cross-sectional survey among Beijing natural population

Received:January 04, 2013 Revised:June 28, 2012

DOI：

KeyWord: 尿酸冠状动脉钙化自然人群

English Key Word: Uric acid Coronary artery calcification Natural population

FundProject:国家"十一五"科技支撑计划

Author Name	Affiliation	E-mail
CAO Hui-li	Departmenx of Radiology	blu@vip.sina.com
LV Bin	Departmenx of Radiology
CHEN Xiong-biao	Departmenx of Radiology
LU Jin-guo	Departmenx of Radiology
HOU Zhi-hui	Departmenx of Radiology
TANG Xiang	Departmenx of Radiology
GAO Yang	Departmenx of Radiology
YU Fang-fang	Departmenx of Radiology
CHEN Yang	Departmenx of Radiology
JIANG Shi-liang	Departmenx of Radiology
ZHAO Lian-cheng	Division for CVD Prevention and Corztrol Network
LI Ying	Division for CVD Prevention and Corztrol Network
GU Dong-feng	Department of Evidence Based Medicine,State Key laboratory of Cardiovascular Disease, Fuwai Hospital,National Center for Cardiovascular Disease Sciences and Peking Union Medical College,Beijing 100037,China Academy of Medical
顾东风	1. Departmenx of Radiology 2. Division for CVD Prevention and Corztrol Network 3. Department of Evidence Based Medicine,State Key laboratory of Cardiovascular Disease, Fuwai Hospital,National Center for Cardiovascular Disease Sciences and Peking Union Medical College,Beijing 100037,China Academy of Medical

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Abstract:

目的探讨自然人群血尿酸对冠状动脉钙化的影响.方法2012年4-7月对903名(男37 ～ 76岁,女42～76岁)北京市西山社区人群进行心血管危险因素调查、血生化检查及CT冠状动脉钙化扫描.结果尿酸水平位于第1四分位数(1 Q)、2～3Q、4Q人群的冠状动脉钙化率分别为37.2%、45.5%、60.6%(P<0.001),冠状动脉钙化积分分别为(109.7±333.1)AU、(133.9±356.9)AU、(200.8±459.4)AU(P<0.001).单因素logistic回归分析显示随尿酸水平升高冠状动脉钙化风险增加(2～3 Q:OR=1.41,95%CI:1.02～1.95,P=0.040；4 Q:OR=2.60,95%CI:1.78～3.80,P<0.001),但多因素logistic回归分析中尿酸与冠状动脉钙化的关系消失(2～3 Q:OR=0.92,95%CI:0.60～ 1.43,P=0.713;4 Q:OR=1.38,95%CI:0.80～ 2.39,P=0.247).结论北京市社区人群冠状动脉钙化率及钙化程度随尿酸水平升高而增加,但血尿酸水平并非冠状动脉钙化的独立危险因素.

English Abstract:

Objective To investigate the influence of uric acid on coronary artery calcification in the natural population in Beijing.Methods From April to July 2012,903 subjects from the natural population (aged 37-76 years for men,aged 42-76 years for women) in Xishan community,Beijing,were selected to accept a survey on the risk factors of cardiovascular.Blood tests and CT coronary artery calcium scans were carried out.Results At the 1 Quartile (1 Q),2 to 3 Quartile (2-3 Q) and 4 Quartile (4 Q) of uric acid levels,the prevalence rates of coronary artery calcium were 37.2%,45.5%,60.6% (P<0.001) and the coronary artery calcium scores were (1 09.7 ± 333.1)AU,(133.9 ± 356.9) AU,(200.8 ± 459.4) AU(P<0.001) respectively.Data from the univariate logistic regression analysis showed that with the increase of uric acid,the prevalence rates of coronary artery calcium also increased (OR2-3Q=1.41,95% CI:1.02-1.95,P=0.040; OR4Q=2.60,95% CI:1.78-3.80,P<0.001).However,the relationship between uric acid and coronary artery calcium disappeared when using the multivariate logistic regression analysis (OR2-3Q=0.92,95%CI:0.60-1.43,P=0.713; OR4Q=l.38,95% CI:0.80-2.39,P=0.247).Conclusion Uric acid did not seem to be an independent risk factor for coronary artery calcium,although the prevalence and extent of coronary artery calcium increased along with the increasing trend of uric acid.

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