| 罗霞,孙强正,徐建国.福氏志贺菌O-抗原修饰及血清型转换机制研究进展[J].Chinese journal of Epidemiology,2013,34(7):750-753 |
| 福氏志贺菌O-抗原修饰及血清型转换机制研究进展 |
| O-antigen modification and serotype conversion of Shigella flexneri |
| Received:February 21, 2013 |
| DOI：10.3760/cma.j.issn.0254-6450.2013.07.021 |
| KeyWord: 福氏志贺菌 O-抗原修饰 血清型转换 血清型转换噬菌体 质粒 |
| English Key Word: Shiglla flexneri 0-antigen modification Serotype conversion Serotype-converting bacteriophages Plasmid |
| FundProject: |
| Author Name | Affiliation | E-mail | | LUO Xia | State Key Laboratory for Infectious Diseases Prevention and Control, National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijinng 102206, China | | | SUN Qiang-zheng | State Key Laboratory for Infectious Diseases Prevention and Control, National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijinng 102206, China | | | XU Jian-guo | State Key Laboratory for Infectious Diseases Prevention and Control, National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijinng 102206, China | xujianguo@icdc.cn |
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| Abstract: |
| 该项研究结果说明采用血清型转换噬菌体位点特异性整合系统修饰O-抗原血清型的方法, 可以有效介导外源基因进入细菌染色体的特异性位点, 而不会干扰宿主菌中任何重要基因的表达, 对疫苗的研究具有重要意义。 |
| English Abstract: |
| With R, this study involved the application of the spline-based Cox regression to analyze data related to follow-up studies when the two basic assumptions of Cox proportional hazards regression were not satisfactory. Results showed that most of the continuous covariates contributed nonlinearly to mortality risk while the effects of three covariales were time-dependent. After considering multiple covariatcs in spline-based Cox regression, when the ankle brachial index (ABI) decreased by 0.1, the hazard ratio (HR) for a11-cause death was l.071. The spline-based Cox regression method could be applied to analyze the data related to follow-up studies when the assumptions of Cox proportional hazards regression were violated. |
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