美沙酮维持治疗门诊HIV阳性服药人员 吸毒过量死亡的影响因素分析

崔宁; 曹晓; 王常合; 罗巍; 庞琳; 柔克明; 吴尊友

Abstract

崔宁,曹晓,王常合,罗巍,庞琳,柔克明,吴尊友.美沙酮维持治疗门诊HIV阳性服药人员吸毒过量死亡的影响因素分析[J].Chinese journal of Epidemiology,2013,34(10):961-963

美沙酮维持治疗门诊HIV阳性服药人员吸毒过量死亡的影响因素分析

Factors associated with overdose．caused mortality of HIV．positive patients who were on methadone maintenance treatment program

Received:June 03, 2013

DOI：

KeyWord: 美沙酮维持治疗|艾滋病病毒|吸毒|死亡

English Key Word: Methadone maintenance treatmen|HIV|Drag takin|Mortality

FundProject:国家“十二五”科技重大专项(2012ZXl0001007—002)；中国艾滋病，结核病多学科研究培训项目(5U2RTW006918)

Author Name	Affiliation	E-mail
CUI Ming	School of Public Health, Anhui Medical, Hefei 230032, China National Center for AIDS/STD Controf and Prevention, Chinese Center for Disease Contr02 and Prention
CAO Xiao-bin	National Center for AIDS/STD Controf and Prevention, Chinese Center for Disease Contr02 and Prention
WANG Chang-he	National Center for AIDS/STD Controf and Prevention, Chinese Center for Disease Contr02 and Prention
LUO Wei	National Center for AIDS/STD Controf and Prevention, Chinese Center for Disease Contr02 and Prention
ROU Ke-ming	National Center for AIDS/STD Controf and Prevention, Chinese Center for Disease Contr02 and Prention
WU Zun-you	National Center for AIDS/STD Controf and Prevention, Chinese Center for Disease Contr02 and Prention
吴尊友	School of Public Health, Anhui Medical, Hefei 230032, China National Center for AIDS/STD Controf and Prevention, Chinese Center for Disease Contr02 and Prention	wuzy@263.net

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Abstract:

目的分析影响美沙酮维持治疗(MMT)门诊HIV阳性服药人员吸毒过量死亡的因素。方法采用1：l配对病例对照研究方法，对1lO例因吸毒过量死亡的服药人员与相应对照 (与病例同性别、同门诊、首次入组时间相近)的社会人El学、吸毒行为、服药行为等特征进行比较。结果多因素logistic回归模型分析表明，人组前3个月共用针具(OR=5．19，95％CI：1．39。 19．33)、经注射吸毒感染HIV(OR=3．08，95％CI：1．16—8．21)、终点前脱失(OR=2．54，95％CI： 1．23—5．23)是吸毒过量死亡的危险因素，而治疗依从性好(OR=O．31，95％CI：0．10．0．95)为保护 l因素。结论应采取综合措施提高MMT门诊服药病例的依从性，并对曾共用针具的病例展开重点干预，从而减少死亡。

English Abstract:

Objective To study the factors that associated with the mortality of overdose on methadone maintenance treatment(MMT)among HIV-positive patients．Methads A l：1 matched case-control design was used to identify the relationship between factors related to demography，drug use．characteristics of treatment and the mortality of overdose．1 10 HIV-positive patients who died of drug overdose from March 2004 to September 2012 were defined as cases．Controls were another 110 patients who were still alive and paired with the cases，according to the same gender，similar date of MMT initiation and from the same clinics．Results Multivariate conditional logistic regression analyses indicated that risk factors as sharing needles before enrolled in the MMT program(OR= 5．19，95％cj：1．39—19．33)，HIV infection because of injecting drug-use(OR=3．08，95％CI： 1．16—8．21)。and Off from the treatment before the end point of the program(OR=2．54，95％C/： 1．23—5．23)were associated with mortality caused by overdose．Higher adherence(OR=0．3l，95％(7/： 0．1 0—0．95)appeared to be associated with lower mortality when compared with the control group． Conclusion In order to reduce the mortality rate．Conclusioncomprehensive intervention could be introduced to improve the compliance of retention on MMTamong patients．Intervention efforts should be focused on those patients who shared needle|syringes．

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