| 张嘉越,李松明,冷津立,陈佑江,浦涧,李金明,庞飞雄,黄永鸿,农江,岑延增,何辉,李瑞,丽宁,何红艳.广西壮族自治区普遍食盐加碘对甲状腺 疾病谱的影响[J].Chinese journal of Epidemiology,2013,34(10):970-974 |
| 广西壮族自治区普遍食盐加碘对甲状腺 疾病谱的影响 |
| Changes of the spectrum on thyroid disease after the ten--year implementation of universal salt iodization in Guangxi Zhuang Autonomous Regio |
| Received:May 27, 2013 |
| DOI：10．3760/cma．j issn．0254—6450 2013．10．007 |
| KeyWord: 甲状腺疾病|碘营养|疾病谱 |
| English Key Word: hyroid disease|Iodine nutritio|Spectrum of thyroid diseases |
| FundProject:广西壮族自治区自然科学基金(0728254) |
| Author Name | Affiliation | E-mail | | ZHANG Jia-yue | 1 Department of General Surgery, Department ofPathology, No. 303 Hospital of P“, Nanning 530021, China
| huangyonghong331@163.com | | LI Song-ming | 1 Department of General Surgery, Department ofPathology, No. 303 Hospital of P“, Nanning 530021, China
| | | LING Jin-li | 1 Department of General Surgery, Department ofPathology, No. 303 Hospital of P“, Nanning 530021, China
| | | CHEN You-jiang | Department of General Surgery, No. 181 Hosphal
| | | PU Jian | Department of General Surgery. Hosphal of Guangxi Youjiang Medical College
| | | LI Jin-ming | Oepartment ofGeneral Surgery, People’S Hospital ofBeihai City ofGuangxi
| | | PANG Fei-xiong | 1 Department of General Surgery, Department ofPathology, No. 303 Hospital of P“, Nanning 530021, China
| | | HUANG Yong-hong | 1 Department of General Surgery, Department ofPathology, No. 303 Hospital of P“, Nanning 530021, China
| | | NONG Jiang | Department of Pathology. No. 303 Hoal ofPL4 | | | CEN Yan-zeng | 1 Department of General Surgery, Department ofPathology, No. 303 Hospital of P“, Nanning 530021, China
| | | HE Hui | 1 Department of General Surgery, Department ofPathology, No. 303 Hospital of P“, Nanning 530021, China
| | | LI Rui | 1 Department of General Surgery, Department ofPathology, No. 303 Hospital of P“, Nanning 530021, China
| | | HE Hong-yan | 1 Department of General Surgery, Department ofPathology, No. 303 Hospital of P“, Nanning 530021, China
| | | 何红艳 |
1. 1 Department of General Surgery, Department ofPathology, No. 303 Hospital of P“, Nanning 530021, China
2. Department of General Surgery, No. 181 Hosphal
3. Department of General Surgery. Hosphal of Guangxi Youjiang Medical College
4. Oepartment ofGeneral Surgery, People’S Hospital ofBeihai City ofGuangxi
5. Department of Pathology. No. 303 Hoal ofPL4
| |
|
| Hits: 3594 |
| Download times: 1174 |
| Abstract: |
| 目的分析广西壮族自治区实行全民普遍食盐加碘(USI)前后不同碘环境下甲状腺 疾病谱变迁的特点。方法按地理分布特点选取南宁、桂林、百色、北海4城市医院1991--2006年 经手术后病理确诊5998例甲状腺疾病患者的尿碘水平，并检测1000例甲状腺正常人群尿碘水平 作对照，分析USI前后碘环境的改变与甲状腺病谱变迁的相关性。结果USI后，甲状腺患者及对 照组的尿碘水平均较USl前增高，旦甲状腺疾病患者尿碘水平高于对照组(分别为324．3肛班、 238．5斗g/L，P<0．05)，其中结节性甲状腺肿、毒性弥漫性甲状腺肿、毒性结节性甲状腺肿、慢性淋 巴细胞性甲状腺炎、甲状腺乳头状癌患者尿碘水平较USI前明显增高(分别为263．8“g/L魄69．75 pg/L、289．7 pg/L粥．228．3¨班、346．8 pg/L VS．268A“g/L、350．3 rtg/L掷．316．2}．tg/L、378．5 p叽VS． 305．8“g觅)，而毒性结节性甲状腺肿、甲状腺乳头状癌、慢性淋巴细胞性甲状腺炎的构成比(％)较 USI前增高(分别为7．59诋4．80、5．85 YS．4．02、3．88搬．2A6)，但结节性甲状腺肿较USI前下降 (63．56傩．69．75)。结论广西壮族自治区USI后甲状腺疾病谱发生明显变化，碘摄人过量可能是 毒性结节性甲状腺肿、慢性淋巴细胞性甲状腺炎、甲状腺乳头状癌的危险因素。 |
| English Abstract: |
| Objective To reveal the relationship between iodine nutrition and the c：hange cpf spectrum on thyroid diseases through comparing the different iodine environments pre．and post-．the universalsalt iodization(usl)campaign．Methads To compare the urinary iodine concentration between 1000 normal people and 5998 patients wiith thyroid disease who had undergone surgical operations，from 4 major cities．including jiodine deficient and rich areas of Guangxi Zhuang Autonomous Region．Results After USl was put iinto practice，the urinary jiodine concentration of patients with thyroid appeared higher than those of normal people(324．3 p238．5，P< 0．05)．The urinary iodine concentrations of nodular goiter。Graves disease，toxic nodular goiter． thyroid papillary carcinoma and Hashimoto’S thyroiditis were higher than those before the USl was taken(263．8∥L69．75 p，289．7 I_tg/L US．228．3 I．tg/L，346．8 I．tg/L268．4 p，350．3 I_tg/L． 316．2g/L and 378．5 rtg/L VS．305．8 I_tg/L)．The proportions of toxic nodular goiter，thyroid papillary carcinoma and Hashimoto’S thyroiditis appeared as 7．59％US．4．80％。5．85％。4．02％and 3．88％/3S2．46％，all higher than those before the implementation of USI．except the nodular goiter which showed a reduction(63．56％．69．75％)．Conclusion The spectrum ofthyroid diseases appeared an obvious change in Guangxi within the last 1 0-year implementation of USI．However，the excessive intake of iodine might serve as a risk factor for toxic nodular goiter，thyroid papillary carcinoma and Hashimoto’S thyroiditis． |
|
View Fulltext
Html FullText
View/Add Comment Download reader |
| Close |
|
|
|