孙立梅,李晖,谭小华,方苓,邓爱萍,莫艳玲,何剑峰,柯昌文,林锦炎.2012年广东省5岁以下儿童腹泻病 流行特征及重点病原监测[J].Chinese journal of Epidemiology,2013,34(10):989-992 |
2012年广东省5岁以下儿童腹泻病 流行特征及重点病原监测 |
Epidemiological and etiological characteristics of diarrheal disease among children under 5 years of age in Guangdong province,in 2012 |
Received:May 23, 2013 |
DOI:10.3760/cma.j.issn.0254—6450.2013.10.011 |
KeyWord: 腹泻病|症状监测|轮状病毒|诺如病毒|基因分型 |
English Key Word: iarrheal disease|Syndromic surveillance|Rotavirus|Norovirus|Genotype |
FundProject:广东省医学科研项目(A2012085) |
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Abstract: |
目的探讨广东省<5岁儿童腹泻病流行特征和重点病原监测。方法2012年在 广东省21个地市选择64家医院开展腹泻症状监测,其中14家医院采集<5岁儿童腹泻病粪便标 本,开展霍乱弧菌、志贺菌分离培养及轮状病毒、诺如病毒ELISA、PCR检测。分析52周腹泻病症 状监测数据和1932例<5岁儿童腹泻病重点病原监测结果。结果2012年广东省<5岁儿童腹 泻就诊病例占监测门诊就诊总人次数的O.8%,占监测门诊全年龄组腹泻病例就诊总人次数的 63.5%;以医院为基础报告<5岁儿童感染性腹泻病年发病率为1454.5/10万。全年采集<5岁儿 童腹泻病标本1932份,检测霍乱弧菌均为阴性,宋内志贺菌1例阳性,轮状病毒阳性率为14.1% (273/1932),诺如病毒阳性率为16.9%(326/1932),诺如病毒和轮状病毒合并感染24例(1.2%)。 112份轮状病毒和90份诺如病毒阳性标本测序表明,轮状病毒主要以G1[P8]为主(33.9%),其 次为G9[P8](25.9%)、G2[P4](12.5%)、G3[P8](9.8%);诺如病毒以GII.4型为主(76.7%),并检 出5份G I型和16份GⅡ其他型/变异株,除6月(未开展测序工作)和12月外其余各月均检出 GⅡ.4/2006b型(占50.0%),GII。4/Sydney 2012变异株于8月首次检出并在12月成为流行优势 株。结论<5岁儿童是广东省腹泻病高危人群,感染的轮状病毒和诺如病毒具有基因多样性。 |
English Abstract: |
Objective To analyze the epidemiological and etiological characteristics of diarrheal disease among children under 5 years of age in Guangdong province,in 20 1 2.Methads 64 hospitals in 21 cities were chosen as the diarrheal syndromic surveillance sites,of which 14 hospitals were selected to carry out etiological surveillance among children under 5 years of age,including is01.ion and culture of both V/brio cholera and Shigella as well as nucleic acid detection of rotavirus and norovirus by PCR.Descriptive method was used to analyze data from syndromic and etiological surveillance programs on diarrheal.from 1 932 parents of the children,Results In 2012,the outDatient aRendance rate on diarrheal among children under 5 years was 0.8%.The proportion of diarrheal in children under 5-year-olds was 63.5%,among the total number of diarrheal outrIatients at the outpatient clinics under surveillance program.The morbidity of infectious diarrhea was l 454.5/1 0 million in children under 5 years of age.A total number of l 932 specimens were collected from children under 5 years of age,in the outpatient department.Among these specimens,Vibrio cholera appeared all negative but one was Shigella positive and proved to be Sh.SOD,nei.The positive rates of rotavirus and norovirus were 14.1%(273/1932)and 16.9%(326/1932).Both rotavirus and norovirus were found in 24 specimens.with a positive rate as 1.2%.11 2 specimens were successfully gene— sequenced for rotavirus.ofwhich 33.9%as G1[P8]genotype,25.9%as G9[P8 J,12.5%as G2lP4 J and 9.8%as G3[P8]respectively.90 specimens were successfully gene-sequenced for norovirus,ofwhich 76.7%as G II.4 genotype.Genetic subtypes of GⅡ.4/2006b,accounted for 50.0%and could be detected around the year except for June and December.New G II.4/Sydney Strain——2012 was first detected in August and became the predominant in December.In addition,5 specimens belonged to G I genotype with other 16 subtypesConclusion Results from our study proved that children under 5 years of age belonged to high-risk group for diarrheal disease in Guangdong province. |
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