| 罗俊一,马依彤,谢翔,杨毅宁,马翔,付真彦,李晓梅,于子翔,陈邦党,刘芬.细胞问黏附分子一1基因K469E多态性 与新疆维吾尔族人群冠心病的 相关性研究[J].Chinese journal of Epidemiology,2013,34(10):1018-1022 |
| 细胞问黏附分子一1基因K469E多态性 与新疆维吾尔族人群冠心病的 相关性研究 |
| Association between intercellular adhesion molecule一1 K469E polymorphism and coronary heart disease in people诵tIl Uygur ethnicity，in Xinjiang |
| Received:June 25, 2013 |
| DOI：10．3760/cma．j．issn．0254-6450．2013．10．018 |
| KeyWord: 冠心病|细胞间黏附分子一1|单核苷酸多态性 维吾尔族 |
| English Key Word: Coronary heart disease|ntercellular adhesion molecule|Single nucleotide polymorphism|Uygur |
| FundProject:新疆维吾尔自治区科技支撑计划(201233138) |
| Author Name | Affiliation | E-mail | | LUO Jun-yi | Department of Cardiology, First Affiliated Hospital of Xinjiang Medical University, Urumqi 830054, China
| mytxj@163.com | | MA Yi-tong | Department of Cardiology, First Affiliated Hospital of Xinjiang Medical University, Urumqi 830054, China
| | | XIE Xiang | Department of Cardiology, First Affiliated Hospital of Xinjiang Medical University, Urumqi 830054, China
| | | YANG Yi-ning | Department of Cardiology, First Affiliated Hospital of Xinjiang Medical University, Urumqi 830054, China
| | | MA Xiang | Department of Cardiology, First Affiliated Hospital of Xinjiang Medical University, Urumqi 830054, China
| | | FU Zhen-yan | Department of Cardiology, First Affiliated Hospital of Xinjiang Medical University, Urumqi 830054, China
| | | LI Xiao-mei | Department of Cardiology, First Affiliated Hospital of Xinjiang Medical University, Urumqi 830054, China
| | | YU Zi-xiang | Department of Cardiology, First Affiliated Hospital of Xinjiang Medical University, Urumqi 830054, China
| | | CHEN Bang-dang | Xinjiang Key Laboratory ofCardiovascular Disease Research | | | LIU Fen | Xinjiang Key Laboratory ofCardiovascular Disease Research | |
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| Abstract: |
| 目的探讨细胞间黏附分子一1基因K469E位点在新疆维吾尔(维)族人群中的分布 特点及与冠心病的相关性。方法应用聚合酶链反应一限制性片段长度多态性方法对新疆地区 维族245例冠心病患者和377例健康受试者细胞间黏附分子基因一1第6外显子K469E位点进行 基因型分析。结果冠心病组与对照组基因型分布均符合Hardy．Weinberg平衡(P>0．05)。冠心 病组与对照组中3种基因型分布的差异有统计学意义(P=0．039)，K与E等位基因分布的差异也 有统计学意义(P=0．031)；在男性亚组中冠心病组与对照组3种基因型分布的差异有统计学意义 (P=0．029)，等位基因分布差异均有统计学意义(P=0．025)；在女性亚组中基因型及等位基因分 布的差异均无统计学意义。经调整混杂因素后，logistic回归分析提示KK基因型为维族男性人群 冠心病发生的危险因素(OR=2．389，95％CI：1．458—3．915，P=0．001)。结论细胞间黏附分子一l 基因第6外显子K469E基因多态性和新疆维族男性冠心病的发生具有相关性，KK基因型是冠心 病发生的危险因素。 |
| English Abstract: |
| Objective To explore the distribution on K469E single nucleotide polymorphism of ICAM—l gene among people with Uygur ethnicity，in Xinjiang and to analyze the correlation between ICAM一1 gene polymorphism and coronary heart disease．Methads 245 patients with coronary heart disease patients and 377 healthy controls in Xinjiang Uygur population were studied． ICAM一1 gene K469E genotype located in exon 6 were detected by polymerase chain reaction-restricted fragments length polymorphism．Results Distribution of genotypes in the two groups appeared to be in Hardy-Weinberg equilibrium(P>0．05)．The distribution of genotypes showed significant difference between the two groups(P=0．039)and the distributions of K and E allele also presented statistically significant difference(P=0．03 1)．Significant difference was also observed in males(P=0．029 for genotype。P=0．025 for allele)but not in females．After adjusted for confounding factors，results from logistic regression analysis indicated that KK genotype was a risk factor for CHD in Uygur male population(OR=2．389，95％CI：1．458—3．915。P=O．001)． Conclusion Genetic polymorphism of ICAM一1 K469E might increase the risk for coronary artery disease in males of Uygur patients in Xinjiang． |
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