过氧化物酶体增殖物激活受体多态性 及其单体型对C反应蛋白的影响 及与体重异常的交互作用

俞璐刚; 周正元; 郭志荣; 武呜; 顾淑君

Abstract

俞璐刚,周正元,郭志荣,武呜,顾淑君.过氧化物酶体增殖物激活受体多态性及其单体型对C反应蛋白的影响及与体重异常的交互作用[J].Chinese journal of Epidemiology,2013,34(10):1023-1028

过氧化物酶体增殖物激活受体多态性及其单体型对C反应蛋白的影响及与体重异常的交互作用

Roles of peroxisome proliferator—activated receptors polymorphisms，haplotypes，levels on C-reactive protein and their interactions with abnormal body weight

Received:May 27, 2013

DOI：10．3760/cma．j．issn．0254—6450．2013．10．019

KeyWord: 体重异常|过氧化物酶体增殖物激活受体|C反应蛋白交互作用

English Key Word: Abnormal weight|Peroxisome proliferator-activated receptors|C-reactive protein|Interaction

FundProject:卫生部科学研究基金(WKJ2004—2—014)

Author Name	Affiliation	E-mail
ZHOU Lu-gang	Suzhou lndustriaf Center for Disease Control and Mention, Suzhou 2 l 502 l, China	guozhiron928@163.com
ZHOU Zheng-yuan	Changshu Center for Disease Control and PMention；
GUO Zhi-rong	Department of idemiology, School ofPublic Heahh, Soochow University
WU Ming	Jiangsu Provincial Center Disease Control and Prevention
GU Shu-jun	Department of idemiology, School ofPublic Heahh, Soochow University

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Abstract:

目的探讨过氧化物酶体增殖物激活受体(PPAR)a/8/'l，多态性及单体型与C反应蛋白(CRP)的关联，并分析单体型和体重异常的交互作用对CR．P的影响。方法在“江苏省多代谢异常和代谢综合征综合防治研究队列人群”的基础上，采用单纯随机抽样方法，选取644名研究对象。应用方差和t检验，以线性回归模型分析单核苷酸多态性(SNP)基因型与CRP水平的关联。采用SNPStats软件对PPAR-i个亚型SNP分别构建单体型，并分析单体型与体重异常的交互作用对CRP水平的影响。结果调整性别、年龄、血压、吸烟和饮酒等因素后，rsl800206和rs9794与 CRP水平有显著关联(P<0．05)。调整相同因素后，PPARa中AVG和CVG两个单体型、PPAR8中 CG单体型与CRP水平升高有关(P<0．05)；PPARfi中CC单体型、PPAR了中CPCAC单体型与CRP 水平降低有关(P

English Abstract:

Objective To explore the roles of peroxisome proliferator-activated receptors (PPARs)on the levels of serum C．reactive protein(CRP)and the interactions of PPARs haplotypes with abnormal body weight．Methads Subjects(n=644)were randomly selected from the cohort ‘Prevention of Multiple metabolic disorders and Metabolic syndrome in Jiangsu province(PMMJS)’． Variance test．t test and lineal regression were used to analyze the associations between PPARs polymorphisms and the levels of CRP．The association between PPARs haplotypes and serum C：RP levels as well as the interaction of PPARs haplotypes with abnormal body weight were analyzed，under the SNPStats software．Results After adjusting for sex，age，blood pressure，cigareae smoking， alcohol drinking and SO on．data showed that both rs 1 800206 and rs9794 were associated with the changes along with the levels of CI冲(P<0．05)．After adjusting for me same factors，haplotypes of AVG and CVG in PPARa．CG in appeared to be associated with the increase(P<0．05)while haplotypes of CC in PPAR6．CPCAC in PPARy were associated with the decrease of CRP levels(P<0．05)．Results from the Interaction analysis also noted that the interactions did exist between abnormal body weight and both AVG，CVG in PPARa，and CG in PPAR5．Conclusion PPARs polymorphisms and haplotypes were associated with CRP．Interaction between PPAR“6 and abnormal body weight might contribute to the levels of CRP．

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