| 罗俊一,马依彤,谢翔,杨毅宁,李晓梅,于子翔,贺春辉,陈邦党,刘芬.CD36基因多态性与急性冠脉综合征关联性的研究[J].Chinese journal of Epidemiology,2014,35(2):200-204 |
| CD36基因多态性与急性冠脉综合征关联性的研究 |
| Association between the single nucleotide polymorphisms of human CD36 gene and acute coronary syndrome |
| Received:August 11, 2013 |
| DOI：10.3760/cma.j.issn.0254-6450.2014.02.022 |
| KeyWord: 急性冠脉综合征 CD36基因 单核苷酸多态性 |
| English Key Word: Acute coronary syndrome CD36 gene Single nucleotide polymorphism |
| FundProject:新疆维吾尔自治区科技支撑计划(201233138) |
| Author Name | Affiliation | E-mail | | Luo Junyi | Department of Cardiology, First Affiliated Hospital of Xinjiang Medical University, Urumqi 830054, China | | | Ma Yitong | Department of Cardiology, First Affiliated Hospital of Xinjiang Medical University, Urumqi 830054, China | Email:myt-xj@163.com | | Xie Xiang | Department of Cardiology, First Affiliated Hospital of Xinjiang Medical University, Urumqi 830054, China | | | Yang Yining | Department of Cardiology, First Affiliated Hospital of Xinjiang Medical University, Urumqi 830054, China | | | Li Xiaomei | Department of Cardiology, First Affiliated Hospital of Xinjiang Medical University, Urumqi 830054, China | | | Yu Zixiang | Department of Cardiology, First Affiliated Hospital of Xinjiang Medical University, Urumqi 830054, China | | | He Chunhui | Department of Cardiology, First Affiliated Hospital of Xinjiang Medical University, Urumqi 830054, China | | | Chen Bangdang | Key Laboratory of Cardiovascular Disease
Research, Urumqi | | | Liu Fen | Key Laboratory of Cardiovascular Disease
Research, Urumqi | |
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| Abstract: |
| 目的 探讨新疆地区汉族、维吾尔（维）族人群CD36基因多态性与急性冠脉综合征（ACS）的关联性。方法 采用聚合酶链反应一限制性片段长度多态性（PCR-RFLP）方法，对522例ACS患者和1215名健康体检者CD36基因单核苷酸多态性（SNP）进行基因型鉴定。结果 在汉族和维族人群中，ACS组和对照组rs1722505的基因型及等位基因分布差异均有统计学意义（P值均<0．05）。在汉族人群ACS组中rs17154181的A等位基因频率明显低于对照组（P=0．034）。logistic回归分析在调整混杂因素后，在汉族和维族人群中rs1722505的AA+AG基因型者患ACS风险明显高于GG基因型者，汉族（DR=1．436，95％CI：1．047～1．970，P=0．025），维族（OR=1．589，95％CI：1．009～2．473，P=0．046）。汉族人群rs17154181的AA+AG基因型者患ACS风险明显低于GG基因型者（OR=O．667，95％CI：0．494。0．900，P=0．008）。结论 CD36基因多态性在新疆地区汉族和维族人群闻存在差异，且CD36基因可能与两族人群ACS的发生相关，rs1722505的AA+AG基因型可能是汉族和维族人群ACS的危险因素，rs18154181的AA+AG基因型可能是汉族人群ACS的保护因素。 |
| English Abstract: |
| Objective The aim of the present study was to assess the association between the polymorphisms of CD36 gene and acute coronary syndrome(ACS). Methods Genotypes of CD3b single nucleotide polymorphisms were detected under PCR-RFLP in 522 patients with ACS and 1 215 controls. Results For people under Han and Uygur ethnicities, the distribution of genotypes and allele of rs1722505 was significantly different between ACS and the controls (all P<0.05). For Han population, the frequency of A allele of rs17154181 was significantly lower in ACS group than that in the control group (P=0.034). Results from logistic regression analysis showed that the AA+AG genotype of rs1722505 was significantly higher in ACS patients than that in controls both between the Hans and the Uygurs(OR=1.436,95%C1:1.047-1.970,P=0.025;OR=1.589, 95%C1:1.009-2.473， P=0.046, respectively). For Han people, AA+AG genotype of rs17154181 was significantly lower in ACS patients than that in controls (OR=0.667, 95% CI: 0.494-0.900, P=0.008). Conclusion Data from the present study suggested that the CD36 gene might serve as a genetic marker of ACS in both Han and Uygur populations. |
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