| 刘君玲,孙贺元,王树英.2008--2012年医院重症监护室念珠菌感染情况分析[J].Chinese journal of Epidemiology,2014,35(3):326-328 |
| 2008--2012年医院重症监护室念珠菌感染情况分析 |
| Study OR candida infcetiOIlS in intensivere unit from 2008 to 2012 |
| Received:January 06, 2014 Revised:June 18, 2012 |
| DOI： |
| KeyWord: 念珠菌感染 重症监护室 调查分析 |
| English Key Word: Candida infections Intensive care unit Investigation and analysis |
| FundProject:河北省医学科学研究重点课题计划(08009) |
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| Abstract: |
| 目的调查和分析ICU念珠菌感染情况。方法2008年1月至2012年12月检测天津市第四中心医院ICU所有危重患者痰液、血液等标本中的念珠菌。对5年ICU念珠菌感染情况、阳性检出标本来源分布、小同菌属分布情况以及对常用抗真菌药物的耐药性等进行统计和分析。结果2008--2012年ICU共入住危重患者4 529例次，其中念珠菌感染76例，平均感染率为1 68%；ICU念珠菌感染主要从痰液标本中检出，共52株(68.4%)，血液检出9株(11.8%)，尿液检出8株(10.5%)；5年间ICU检出念珠菌呈现每年递增趋势，菌属分布主要为白色念珠菌感染(36株，47.4%)，其次为光滑念珠菌、热带念珠菌、近平滑念珠菌和葡萄牙念珠菌；念珠菌对伊曲康唑的平均耐药率最高(19.7%)，其次为伏立康唑，耐药率为15.8%。结论ICU的念珠菌感染患者例数及患病率均呈逐年增加趋势，临床主要表现为呼吸道感染，且多为白色念珠菌，并对伊曲康唑的耐药率最高。 |
| English Abstract: |
| ObjectiveTo investigate and analyze the candida infection situation at theintensive care unit(ICU)in Tianjin Fourth Central Hospital from 2008 to 2012.Methods Criticallyill patients admitted in ICU Department in Tianjin Fourth Central Hospital疗om Jan.2008 to Dem.2012 were selected，and candida in all blood，sputum and other specimens of patients.were tested.Data on the following items as：hospital sections and distribution of candida infection on the placeswhere the fungus was identified，distribution of different species of candida，antifungal drug resistanceof candidacies commonly used in ICU department in the last five years etc..were statistically analyzed.Results Among 4 529 cases of critically ill patients stayed in the hospital ICU Department between2008 and 2012.76 cases of candida irifection were identified.with the rate as 1.68%.In the past fiveyears.candida in hospital ICU was mainly detected in sputum samples in 52 cases which accounted for68.4%.Another 9 cases were detected in blood，accounted for 11.8%.8 cases were detected in urine.which accounted for 1 O.5%.36 cases(47.4%)of candida infection detected at the hospital ICUdepartment in the last 5 years with major species as Candida albicans infection.followed by Candidaglabrata，Candida tropicalis，Candida parapsilosis and Poaugal Candida.The highest rate of resistancewas to itraconazole.with a resistance rate of 19.7%，followed by VOriconazole.with the rate as 15.8%.Conclusion In recent years，the number of patients infected with candida at the 1CU department hadincreased annually with most cases as respiratory infections.which were caused by Candida albic口m.The rate of resistance ofcandida to itraconazole was the highest.which called for special attention. |
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