| 赵媛媛,黄玉君,孙业桓.老年虐待的研究进展[J].Chinese journal of Epidemiology,2014,35(3):333-337 |
| 老年虐待的研究进展 |
| Research progress on elder abuse |
| Received:September 01, 2013 |
| DOI： |
| KeyWord: 虐待 老年人 研究 |
| English Key Word: Abuse Old people Pesearch |
| FundProject:2013年安徽省高等教育振兴计划人才项目 |
| Author Name | Affiliation | E-mail | | Zhao Yuanyuan | Department of Epidemiology and Health Statistics, School of Public Health, Anhui Medical University, Hefei 230032, China
The Wth Sanatorium for Retired Cadres. Anhui Provincial Military Regk | yhsun@sina.com | | Huang Yujun | Department of Epidemiology and Health Statistics, School of Public Health, Anhui Medical University, Hefei 230032, China | | | Sun Yehuan | Department of Epidemiology and Health Statistics, School of Public Health, Anhui Medical University, Hefei 230032, China | |
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| Abstract: |
| 结果表明HPV自检法的真实灵敏度和特异度分别为83.53%(95%CI：74.23～89.93)和85.86%(95%C1：84.23～87.36)。随机抽样结果显示，传统方法计算的灵敏度和特异度分别为90.48%(95%C1：80.74-95.56)和71.96%(95%C1：68.71～75.00)，采用逆概率权重法校正后的灵敏度和特异度分别为82，25%(95%CI：63。11-92.62)和85。80%(95%C1：85。09～86.47)；采用最大似然估计法校正后的灵敏度和特异度分别为80.13%(95%CI：66.81.93.46)和85.80%(95%CI：84.20～87.41)。表明在复杂抽样情况下，逆概率权重法能够有效校正存在证实偏倚的灵敏度和特异度 |
| English Abstract: |
| Genome-wide association study is an important approach to identify common genetic variants that predispose to human disease.Because of the high cost of genotyping on hundreds of thousands of markers on thousands of subjects，a more cost-effective two-stage case-control design is applied by most genome-wide association studies.To describe the design and statistical methods of the two-stage case-control study，this paper introduces the principles of two-stage case-control design.its implementing steps in genome-wide associmion study and the features of its application. Thc method is illustrated with an example. |
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