| 张之伦,朱向军,丁亚兴,高志刚,李永成,单爱兰,刘勇,夏卫东.天津市2000-2011年甲型肝炎免疫控制效果评价[J].Chinese journal of Epidemiology,2014,35(10):1127-1130 |
| 天津市2000-2011年甲型肝炎免疫控制效果评价 |
| Evaluation on the hepatitis A vaccine in preventing hepatitis A infection in Tianjin,from 2000 to 2011 |
| Received:March 04, 2014 |
| DOI：10.3760/cma.j.issn.0254-6450.2014.10.011 |
| KeyWord: 甲型肝炎 免疫预防 免疫规划接种 效果评价 |
| English Key Word: Hepatitis A Immunization strategies Vaccination Evaluation studies |
| FundProject: |
| Author Name | Affiliation | E-mail | | Zhang Zhilun | Tianjin Center for Disease Control and Prevention, Tianjin 300011, China | | | Zhu Xiangjun | Tianjin Center for Disease Control and Prevention, Tianjin 300011, China | zhu515@sina.com | | Ding Yaxing | Tianjin Center for Disease Control and Prevention, Tianjin 300011, China | | | Gao Zhigang | Tianjin Center for Disease Control and Prevention, Tianjin 300011, China | | | Li Yongcheng | Tianjin Center for Disease Control and Prevention, Tianjin 300011, China | | | Shan Ailan | Tianjin Center for Disease Control and Prevention, Tianjin 300011, China | | | Liu Yong | Tianjin Center for Disease Control and Prevention, Tianjin 300011, China | | | Xia Weidong | Tianjin Center for Disease Control and Prevention, Tianjin 300011, China | |
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| Abstract: |
| 目的 评价2000-2011 年天津市甲型肝炎（甲肝）免疫控制策略实施效果。方法 采用描述性方法分析天津市2000-2011 年甲肝疫情，评价疫情报告和诊断的可靠性。统计甲肝免疫目标人群接种率，并以血清流行病学方法调查1999、2005 和2010 年健康人群甲肝抗体水平，评价免疫屏障状况。采用多重曲线模型分析天津市甲肝与其他肠道传染病的流行趋势。结果 天津市历经11 年在特定人群1 岁幼儿、小学一年级、初中一年级学生和高危人群中实施甲肝疫苗免疫预防策略，有效控制了甲肝流行。甲肝发病率从2000 年的2.89/10 万降至2011 年的0.12/10万；甲肝在病毒性肝炎中的比例从2000 年的8.02%降到2011 年的0.48%。全市甲肝抗体水平呈现随时间推移增高的趋势。结论 天津市实施的甲肝疫苗免疫策略控制了甲肝流行。 |
| English Abstract: |
| Objective Hepatitis A immunization strategies were carried out in 2001 in Tianjin. We wanted to evaluate the effectiveness of the strategies related to hepatitis A control programs and to provide the basis for further modification of the strategies. Methods Descriptive epidemiology study was used to analyze the hepatitis A epidemic situation in 2000-2011 in Tianjin and to evaluate the disease reporting system. Hepatitis A vaccine coverage of target population and serum epidemiological study were carried out in 1999,2005 and 2010 to check on the hepatitis A antibody levels so as to evaluate the immuno-barrier condition in the normal population. Cox-Stuart test was used to analyze the epidemic trend of hepatitis A and other intestinal infectious diseases in Tianjin. Results The incidence rate of hepatitis A decreased from 2.89/100 000 in 2000 to 0.12/ 100 000 in 2011,and the percentage of hepatitis A in all types of viral hepatitis decreased from 8.02% in 2000 to 0.48% in 2011 in Tianjin. The positive rates of hepatitis A antibody also increased in the residents. Conclusion The hepatitis A vaccination program was successful in the programs on prevention and control of hepatitis A in Tianjin,China. |
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