| 陈秋艳,卜晓青,刘艳,徐娟,孔凡龙,汪桂艳,张永红.白介素6、内皮素1和E选择素与心脑血管病关系的巢式病例对照研究[J].Chinese journal of Epidemiology,2014,35(10):1151-1154 |
| 白介素6、内皮素1和E选择素与心脑血管病关系的巢式病例对照研究 |
| A nested case-control study in studying the relationship between interleukin-6,endothelin-1, E-selectin and the risk of cardio-cerebrovascular events |
| Received:May 22, 2014 |
| DOI：10.3760/cma.j.issn.0254-6450.2014.10.017 |
| KeyWord: 心脑血管病 炎症 关联强度 巢式病例对照 |
| English Key Word: Cardio-cerebrovascular diseases Inflammation Strength of association Nested case-control study |
| FundProject:国家自然科学基金（30972531） |
| Author Name | Affiliation | E-mail | | Chen Qiuyan | Department of Epidemiology, School of Public Health, Medical College of Soochow University, Suzhou, 215123, China | | | Bu Xiaoqing | Department of Epidemiology, School of Public Health, Medical College of Soochow University, Suzhou, 215123, China | | | Liu Yan | Department of Epidemiology, School of Public Health, Medical College of Soochow University, Suzhou, 215123, China | | | Xu Juan | Department of Epidemiology, School of Public Health, Medical College of Soochow University, Suzhou, 215123, China | | | Kong Fanlong | Department of Epidemiology, School of Public Health, Medical College of Soochow University, Suzhou, 215123, China | | | Wang Guiyan | Department of Epidemiology, School of Public Health, Medical College of Soochow University, Suzhou, 215123, China
Department of Health Care, Xiamen Maternal and Child Care Hospital | | | Zhang Yonghong | Department of Epidemiology, School of Public Health, Medical College of Soochow University, Suzhou, 215123, China | yhzhang@suda.edu.cn |
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| Abstract: |
| 目的 研究白介素6（IL-6）、内皮素1（ET-1）及E选择素（E-selectin）与心脑血管事件发生的关系。方法 在对2 589 名蒙古族人群连续随访10 年的队列研究基础上，采用巢式病例对照研究方法，分析IL-6、ET-1 和E-selectin 与心脑血管事件发生的关系，利用logistic 回归分析方法计算OR 值及其95%CI。结果 病例组与对照组的IL-6（7.66 vs. 8.77 pg/ml）、ET-1（0.74 vs. 0.75 pg/ml）和E-selectin（17.96 vs. 18.32 ng/ml）的差异无统计学意义（P>0.05）。logistic分析表明，与IL-6≤23.91 pg/ml 或ET-1≤1.33 pg/ml 或E-selectin≤24.43 ng/ml 者相比，IL-6>23.91 pg/ml 或ET-1>1.33 pg/ml 或E-selectin>24.43 ng/ml 者发生心脑血管事件的多因素调整后的OR 值及其95%CI 分别为0.69（0.41～1.16）、1.10（0.66～1.85）和1.19（0.71～2.00），差异均无统计学意义（P>0.05）。结论 调查人群中基线IL-6、ET-1 及E-selectin 水平与心血管事件危险性无显著关联。 |
| English Abstract: |
| Objective To investigate the relationship between interleukin-6（IL-6）,endothelin-1 （ET-1）,E-selectin and the risk of cardio-cerebrovascular events. Methods Based on a cohort study in which 2 589 Mongolians had been followed up for 10 years,a nested case-control study was carried out to analyze the relationship between IL-6,ET-1,E-selectin and the risk of cardio-cerebrovascular events. Logistic regression analysis was used to calculate the odds ratio（OR） and 95% confidence intervals（95%CI）. Results The average level of IL-6（7.66 vs. 8.77 pg/ml）, ET-1（0.74 vs. 0.75 pg/ml）and E-selectin（17.96 vs. 18.32 ng/ml）were not significantly different between the case and the control groups（P>0.05）. Data from the logistic regression analysis showed that IL-6,ET-1 and E-selectin were not significantly associated with the risk of cardiocerebrovascular events. The multivariable adjusted ORs（95%CI）on the risk of cardio-cerebrovascular events were 0.69 （0.41-1.16）,1.10 （0.66-1.85） and 1.19（0.71-2.00） for the participants with IL-6>23.91 pg/ml ,ET-1>1.33 pg/ml and E-selectin>24.43 ng/ml,respectively,compared with those having IL-6≤23.91 pg/ml ,ET-1≤1.33 pg/ml or E-selectin≤24.43 ng/ml. Conclusion Data from our study indicated that the levels of IL-6,ET-1 and E-selectin at baseline were not significantly associated with the risk of cardio-cerebrovascular events in people from Inner Mongolia. |
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