| 姜斌,何耀,左芳,吴蕾,刘庆辉,张丽,周长喜,郑家强,陈肇始,林大庆.心理干预联合药物对吸烟者的戒烟效果评价[J].Chinese journal of Epidemiology,2014,35(12):1349-1353 |
| 心理干预联合药物对吸烟者的戒烟效果评价 |
| Effectiveness of Varenicline with counseling programs on smoking cessation in a targeted clinical setting in China |
| Received:September 12, 2014 |
| DOI：10.3760/cma.j.issn.0254-6450.2014.12.008 |
| KeyWord: 戒烟 吸烟者 药物和心理干预 观察性研究 |
| English Key Word: Smoking cessation Smoker Varenicline and counseling Observational study |
| FundProject:国家自然科学基金(81373080); 首都医学发展基金(Z121107001012070); 北京市海淀区科普项目(11kp02006); 英国癌症基金会(C1343/A10155) |
| Author Name | Affiliation | E-mail | | Jiang Bin | Department of Traditional Chinese Medicine and Acupuncture, Beijing 100853, China | | | He Yao | Department of Epidemiology, Institute of Geriatrics, Beijing Key Laboratory of Aging and Geriatrics, Beijing 100853, China | yhe301@x263.net | | Zuo Fang | Department of Traditional Chinese Medicine and Acupuncture, Beijing 100853, China | | | Wu Lei | Department of Epidemiology, Institute of Geriatrics, Beijing Key Laboratory of Aging and Geriatrics, Beijing 100853, China | | | Liu Qinghui | Department of Respiration, Beijing 100853, China | | | Zhang Li | Department of Rehabilitation, Nanlou Faculty of Clinical Medicine, Chinese People's Liberation Army General Hospital, Beijing 100853, China | | | Zhou Changxi | Department of Respiration, Beijing 100853, China | | | Cheng KK | Public Health, Epidemiology and Biostatistics, University of Birmingham, UK | | | Chan SC | School of Nursing, The University of Hong Kong, China | | | Lam TH | School of Public Health, The University of Hong Kong, China | |
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| Abstract: |
| 目的 评价伐尼克兰在临床实践中对戒烟门诊患者戒烟的有效性.方法 采用前瞻性观察性研究设计,选择符合纳入标准的吸烟者799人,每名患者首诊时进行标准的基线问卷评估,并在第1、第3和第6个月进行随访.由经过培训的医师对每名患者完成面对面的咨询和个体化戒烟干预.接受药物辅助戒烟者定为心理干预联合药物组(n=272),未用药者为单纯心理干预组(n=527).采用意向性分析的统计学方法分析比较两组的7天时点戒烟率、3个月随访时的1个月持续戒烟率和6个月随访时的3个月持续戒烟率.结果 6个月随访时,心理干预联合药物组的7天时点戒烟率显著高于单纯心理干预组(34.6% vs. 23.1%;OR=1.75,95% CI:1.27～2.42;P<0.001),心理干预联合药物组的3个月持续戒烟率也显著高于单纯心理干预组(31.3% vs. 18.2%;OR=2.04,95%CI:1.46～2.86;P<0.001).1和3个月随访时,心理干预联合药物组无论是7天时点戒烟率还是1个月持续戒烟率均高于单纯心理干预组.结论 在真实临床实践的戒烟门诊中,给予戒烟者药物辅助戒烟可有效提高戒烟率. |
| English Abstract: |
| Objective To evaluate the effectiveness of Varenicline for smoking cessation in a community-based smoking-cessation-clinic (SCC) in Chinese smokers. Methods A prospective observational study was conducted in Beijing,China. 799 smokers (762 men and 37 women) were assessed on data gathered from structured questionnaires at baseline and follow up programs at 1,3 and 6 months. Trained physician counselors provided free individual counseling and follow-up interviews with brief counseling for all the subjects. 272 subjects were additionally prescribed Varenicline according to their own choice and reported data were compared to those without Varenicline. Outcomes were self-reported,regarding the 7-day point prevalence on abstinence rate and continuous abstinence rates at 1,3 and 6 month follow-up periods. Results At 6-month and by intention-to-treat,the 7-day point prevalence on abstinence rate with Varenicline and counseling,was significantly higher than the group with counseling only (34.6% versus 23.1%;OR=1.75,95%CI:1.27-2.42;P<0.001). The 3-month continuous abstinence rate at 6 month was higher in the group with Varenicline (31.3% versus 18.2%;OR=2.04,95%CI:1.46-2.86;P<0.001). Varenicline also showed better outcomes at 1 and 3 month follow-up. Conclusion Varenicline prescription in the smoking cessation clinic appeared to be effective that doubled the rates of quitting among Chinese smokers in the practice at a community-based SCC. |
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