肠道病毒71型所致疾病及其流行病学特征

甘正凯; 李靖欣; 孟繁岳; 胡月梅; 姚学君; 张雪峰; 朱凤才

Abstract

甘正凯,李靖欣,孟繁岳,胡月梅,姚学君,张雪峰,朱凤才.肠道病毒71型所致疾病及其流行病学特征[J].Chinese journal of Epidemiology,2015,36(1):45-48

肠道病毒71型所致疾病及其流行病学特征

Epidemiological characteristics of enterovirus type 71 diseases

Received:July 10, 2014

DOI：10.3760/cma.j.issn.0254-6450.2015.01.011

KeyWord: 肠道病毒71型流行病学

English Key Word: Enterovirus type 71 Epidemiology

FundProject:国家科技重大专项(2012ZX10004-703,2012ZX10002-001)

Author Name	Affiliation	E-mail
Gan Zhengkai	School of Public Health, Southeast University, Nanjing 210009, China
Li Jingxin	Jiangsu Provincial Center for Disease Control and Prevention
Meng Fanyue	Jiangsu Provincial Center for Disease Control and Prevention
Hu Yuemei	Jiangsu Provincial Center for Disease Control and Prevention
Yao Xuejun	School of Public Health, Nanjing Medical University
Zhang Xuefeng	Jiangsu Provincial Center for Disease Control and Prevention	njzhangxf@126.com
Zhu Fengcai	Jiangsu Provincial Center for Disease Control and Prevention	jszfc@vip.sina.com

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Abstract:

目的探讨肠道病毒(EV)71型(EV71)所致疾病的流行特征. 方法对江苏省及北京市7个研究现场10 158名6～35月龄儿童进行为期1年的队列随访, 系统调查EV71所致疾病及其流行病学特征. 结果 EV71感染所致疾病发病密度为15.17/千人年, 其中手足口病、疱疹性咽峡炎、呼吸系统疾病、消化系统疾病和其他疾病分别占82.00%、2.67%、13.33%、1.33%和0.67%. 病例以12～23月龄婴儿为主(58.67%), 不同月龄组发病密度之间的差异有统计学意义(χ²=7.789, P=0.020). 发病时间主要集中在4－6月;重症病例9例(男性7例, 女性2例), 占病例总数的6.00%, 均为手足口病病例;3个年龄段(6～11、12～23、24～35月龄)重症病例分别为1、7、1例. 手足口病、非手足口病病例的病程M值分别为9 d和6 d, 差异有统计学意义(Z=-4.000, P <0.001), 排毒周期的M值分别为9 d和11 d, 差异无统计学意义. 结论 EV71感染所致疾病以手足口病为主, 主要影响婴幼儿, 且具有一定的季节性.

English Abstract:

Objective The objective of this study was to investigate the epidemiological characteristics of disease caused by enterovirus type 71. Methods A total of 10 158 children aged between 6 and 35 months, were recruited from 7 sites where EV71 inactivated vaccine phase 3 clinical trial was carried out. All the subjects were followed up to one year to investigate the epidemiological characteristics of the disease caused by EV71. Results The accumulate incidence density of disease caused by EV71 was 15.17/1 000 person-year. Of all the cases, hand, foot and mouth disease (HFMD), herpangina, respiratory system diseases, digestive system diseases and other diseases accounted for 82.00%, 2.67%, 13.33%, 1.33% and 0.67%, respectively. The difference of the incidence density between boys and girls showed no statistical significance. Majority of the patients were between 12 and 23 months of age, which accounted for 58.67% of the total patients. The differences of incidence density between different months of age were statistically significant (χ²=7.789, P=0.020). The peak incidence density of disease caused by EV71 occurred from April to June. Nine cases showed severe symptoms or signs that accounted for 6.00% of all the cases. All severe cases were identified as HFMD, of which 7 were boys and 2 were girls. The number of severe cases in different months of age appeared to be 1, 7, and 1, all occurred between April and June. The median courses of HFMD cases and non-HFMD cases were 9 and 6 days, with difference statistically significant (Z=-4.000, P <0.001). Median of excretion cycle for HFMD and non-HFMD cases were 9 and 11 days respectively. But with no statistically significant difference between the two. Conclusion Majority of the disease that caused by EV71 appeared as HFMD. Most of them were younger children and with seasonal variation.

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