| 刘白薇,高志勇,王全意,贺雄,贾蕾,李锡太,钱海坤,霍达,曹卫华.北京市2013－2014年肠道门诊腹泻患者中诺如病毒感染的流行病学及临床特征分析[J].Chinese journal of Epidemiology,2015,36(4):383-386 |
| 北京市2013－2014年肠道门诊腹泻患者中诺如病毒感染的流行病学及临床特征分析 |
| Epidemiological and clinical features of norovirus infection among diarrhea patients from the enteric clinics in Beijing, 2013-2014 |
| Received:October 24, 2014 |
| DOI：10.3760/cma.j.issn.0254-6450.2015.04.019 |
| KeyWord: 诺如病毒 腹泻 流行病学 临床特征 |
| English Key Word: Norovirus Diarrhea Epidemiology Clinical feature |
| FundProject:北京市自然科学基金(7132045) |
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| Abstract: |
| 目的 了解北京市肠道门诊腹泻患者诺如病毒感染的流行状况及临床特点。方法 采集2013年4月至2014年3月北京市肠道门诊1 892名腹泻患者粪便标本, 并收集患者的流行病学及临床症状资料。使用real time RT-PCR对诺如病毒核酸进行检测, 采用描述性流行病学方法进行分析。结果 2013年4月至2014年3月北京市肠道门诊腹泻患者诺如病毒阳性率为14.2%(269/1 892);寒冷月份阳性率较高;怀柔区、延庆县等西北部山区阳性率较高;6月龄至5岁儿童诺如病毒阳性率高于其他年龄组, 差异有统计学意义(P=0.006), 散居托幼儿童诺如病毒阳性率高于其他职业人群, 差异有统计学意义(P=0.025);诺如病毒阳性腹泻患者恶心、呕吐症状发生率高于阴性患者, 差异有统计学意义(P<0.05)。结论 诺如病毒是肠道门诊腹泻患者的重要病原, 6月龄至5岁腹泻儿童诺如病毒感染率高于其他人群, 恶心、呕吐为诺如病毒感染的常见症状。 |
| English Abstract: |
| Objective To investigate the epidemiological and clinical characteristics of norovirus infection on diarrhea patients from the enteric clinics in Beijing. Methods From April 2013 to March 2014, 1 892 fecal specimens and related epidemiological information were collected among diarrhea patients visiting the enteric clinics in Beijing. Norovirus was detected by real time RT-PCR, and data was analyzed under the descriptive epidemiological method. Methods A total of 269 positive cases were found among 1 892 diarrhea patients, with a positive rate as 14.2%. Norovirus caused diarrhea mainly occurred in seasons with lower temperature. Higher positive rates of norovirus were found in northwest mountainous area. Norovirus diarrhea was more commonly seen in children between 6 month and 5 years old, with differences between the two groups statistically significant (P=0.006). Compared with other occupation, a higher infection rate was identified in children, with differences between the two groups statistically significant (P=0.025). Nausea and vomiting appeared more common in diarrhea patients with norovirus infection, with differences between the two groups statistically significant (P<0.05). Conclusion Norovirus was an important pathogen which causing diarrhea in patients visiting the enteric clinics in Beijing. The virus was seen more in patients aged between 6 months and 5 years old. Nausea and vomiting were the common symptoms seen in patients with norovirus diarrhea. |
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