浙江省2009-2013年单阳家庭配偶HIV血清学阳转率分析

陈琳; 潘晓红; 杨介者; 徐云; 郑锦雷; 蒋均; 何林

Abstract

陈琳,潘晓红,杨介者,徐云,郑锦雷,蒋均,何林.浙江省2009-2013年单阳家庭配偶HIV血清学阳转率分析[J].Chinese journal of Epidemiology,2015,36(8):857-861

浙江省2009-2013年单阳家庭配偶HIV血清学阳转率分析

Incidence rate of HIV transmission in HIV discordant couples in Zhejiang province, 2009-2013

Received:January 22, 2015

DOI：10.3760/cma.j.issn.0254-6450.2015.08.019

KeyWord: 艾滋病病毒夫妻感染状况不一致队列研究

English Key Word: HIV Discordant couples Cohort study

FundProject:国家科技重大专项(2012ZX10001001)

Author Name	Affiliation	E-mail
Chen Lin	Zhejiang Provincial Center for Disease Control and Prevention, Hangzhou 310051, China
Pan Xiaohong	Zhejiang Provincial Center for Disease Control and Prevention, Hangzhou 310051, China	xhpan@cdc.zj.cn
Yang Jiezhe	Zhejiang Provincial Center for Disease Control and Prevention, Hangzhou 310051, China
Xu Yun	Zhejiang Provincial Center for Disease Control and Prevention, Hangzhou 310051, China
Zheng Jinlei	Zhejiang Provincial Center for Disease Control and Prevention, Hangzhou 310051, China
Jiang Jun	Zhejiang Provincial Center for Disease Control and Prevention, Hangzhou 310051, China
He Lin	Zhejiang Provincial Center for Disease Control and Prevention, Hangzhou 310051, China

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Abstract:

目的了解HIV单阳夫妻配偶HIV血清阳转情况及其相关影响因素。方法对浙江省艾滋病综合防治信息系统下载的数据进行整理, 选取2009-2013年配偶首次检测结果阴性的HIV单阳夫妻为研究对象, 研究内容包括一般特征、感染危险行为、抗病毒治疗、配偶HIV血清阳转情况、阳转夫妻基本特征。结果 2009-2013年2 575对HIV单阳夫妻配偶HIV血清学总阳转率为3.56/1 000人年, 年阳转率从2009年5.49/1 000人年下降至2013年3.20/1 000人年。经异性性行为感染的男性感染者配偶HIV阳转率逐年上升, 女性感染者的配偶HIV阳转率有所下降。抗病毒治疗1年以上(OR=0.063, 95%CI: 0.019~0.204)是预防配偶HIV阳转的保护性因素, 先证者感染时间在3年及以上(OR=3.564, 95%CI: 1.296~9.804)、外省户籍(OR=2.626, 95%CI: 1.098~6.230)是配偶HIV阳转的危险因素。结论浙江省艾滋病单阳家庭配偶HIV血清学阳转率低, 地区分布不平衡。以异性性行为感染的男性感染者配偶阳转率有所上升, 重点关注外省户籍女性先证者单阳家庭。抗病毒治疗、感染时间、户籍是配偶HIV阳转的影响因素。

English Abstract:

Objective To identify the HIV transmission in discordant couples and the epidemic characteristics of concordant couples related to HIV infection. Methods HIV/AIDS database was down-loaded from AIDS information reported system for analysis. Patients with HIV-negative couples between 2009 and 2013 in Zhejiang province were enrolled in this study. Information included demography characteristics, highly active antiretroviral therapy (HAART), HIV incidence rate and risk factors, characteristics on HIV concordant couples. Results The HIV incidence rate on HIV-negative couples of 2 575 HIV/AIDS was 3.56 per 1 000 person-year, reducing from 5.49 per 1 000 person-year in 2009 to 3.20 per 1 000 person-year in 2013. There was a slight increase on HIV incidence rate among couples in those HIV-positive men who were heterosexual, while it decreased among couples of HIV-positive women. Initiation of HAART over 1 years(OR=0.063, 95%CI: 0.019-0.204) seemed to be a preventive factor for HIV transmission between the couples under study. Factors as history of infection longer than 3 years(OR=3.564, 95%CI: 1.296-9.804) and beingnon-local resident (OR=2.626, 95%CI: 1.098-6.230) were risky factors. Conclusion The incidence rate of HIV transmission between HIV discordant couples was low but imbalance in different areas. People who were non-local residents under HIV discordant status, would need more attention. HAART, time of infection, status of residency appeared risk factors for HIV transmission within the couples.

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