| 兰丰铃,吕筠,郭彧,卞铮,余灿清,周汇燕,谭云龙,裴培,曹卫华,陈君石,陈铮鸣,李立明.中国慢性病前瞻性研究:10个项目地区成年人肺功能指标水平和气流受限现患率的差异分析[J].Chinese journal of Epidemiology,2015,36(11):1205-1209 |
| 中国慢性病前瞻性研究:10个项目地区成年人肺功能指标水平和气流受限现患率的差异分析 |
| Area specific differences in lung function indices and prevalence of airflow obstruction in adults: findings from people in 10 areas in China |
| Received:July 22, 2015 |
| DOI：10.3760/cma.j.issn.0254-6450.2015.11.005 |
| KeyWord: 肺功能 气流受限 地区差异 |
| English Key Word: Lung function Airflow obstruction Area specific difference |
| FundProject:国家自然科学基金(81390541,81390544); 香港Kadoorie Charitable基金; 英国Wellcome Trust(088158/Z/09/Z); 国家科技支撑计划(2011BAI09B01) |
| Author Name | Affiliation | E-mail | | Lan Fengling | Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing 100191, China | | | Lyu Jun | Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing 100191, China | | | Guo Yu | Chinese Academy of Medical Sciences | | | Bian Zheng | Chinese Academy of Medical Sciences | | | Yu Canqing | Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing 100191, China | | | Zhou Huiyan | Chinese Academy of Medical Sciences | | | Tan Yunlong | Chinese Academy of Medical Sciences | | | Pei Pei | Chinese Academy of Medical Sciences | | | Cao Weihua | Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing 100191, China | caoweihua60@163.com | | Chen Junshi | National Center for Food Safety Risk Assessment of China | | | Chen Zhengming | Clinical Trial Service Unit and Epidemiological Studies Unit(CTSU), Nuffield Department of Population Health, University of Oxford, UK | | | Li Liming | Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing 100191, China
Chinese Academy of Medical Sciences | |
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| Abstract: |
| 目的 描述中国慢性病前瞻性研究(CKB)10个地区人群肺功能指标水平和气流受限现患率的地区差异。方法 剔除基线调查时肺功能指标异常个体后,分析10个地区512 495名30～79岁调查对象肺功能指标水平(FEV1和FVC)和气流受限(分别采用GOLD标准和LLN标准进行判断)现患率的地区差异。结果 10个地区男性的FEV1(2.66 L)和FVC(3.16 L)均高于女性(1.99 L和2.35 L);河南和哈尔滨人群FEV1和FVC高于其他地区。基于GOLD标准的气流受限现患率:男性(5.13%)高于女性(3.75%);农村人群高于城市(男性:6.32% vs. 3.47%;女性:4.26% vs. 2.97%);四川人群现患率最高(男性为13.34%,女性为10.70%),其次是苏州、河南和湖南。基于LLN标准的气流受限现患率(男性为6.93%,女性为6.29%)略高于GOLD标准,但地区差异近似。结论 CKB的10个地区人群无论在肺功能指标水平和气流受限现患率上均存在明显的地区差异。 |
| English Abstract: |
| Objective To describe the area specific differences in lung function indices and prevalence of airflow obstruction (AFO) in adults found by China Kadoorie Biobank (CKB) study, involving 512 495 adults, in 10 areas in China. Methods The detailed information on lung function indices (FEV,and FVC) and prevalence of AFO (diagnosed according to GOLD and LLN criteria) of subjects aged 30-79 years were analyzed, those with abnormal lung function indices at baseline survey were excluded. Results The FEV1 and FVC among males (2.66 L,3.16 L) were higher than those among females (1.99 L, 2.35 L). The FEV1 and FVC were highest in Henan and Harbin. The prevalence of AFO diaonosed according to GOLD criteria was 5.13% in males, higher than that in females (3.75%). The prevalence of AFO was higher in rural area than in urban area (males: 6.32% vs. 3.47%; females: 4.26% vs. 2.97%). The prevalence of AFO was highest in Sichuan (13.34% in males, 10.70% in females), followed by that in Suzhou, Henan and Hunan. The prevalence of AFO diagnosed according to LLN criteria (6.93% in males, 6.29% in females) was higher than that diagnosed according to GOLD criteria, but the area specific difference was similar. Conclusion The lung function indices and the prevalence of AFO in adults varied greatly among the 10 areas covered by CKB study. |
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