云南省德宏州2014年HIV-1耐药传播警戒线调查

陈敏; 王继宝; 邢辉; 马艳玲; 杨锦; 陈会超; 姚仕堂; 罗红兵; 段星; 王译葵; 段松; 贾曼红

Abstract

陈敏,王继宝,邢辉,马艳玲,杨锦,陈会超,姚仕堂,罗红兵,段星,王译葵,段松,贾曼红.云南省德宏州2014年HIV-1耐药传播警戒线调查[J].Chinese journal of Epidemiology,2016,37(2):206-209

云南省德宏州2014年HIV-1耐药传播警戒线调查

Study on the threshold of HIV-1 drug resistance in Dehong prefecture of Yunnan province in 2014

Received:July 11, 2015

DOI：10.3760/cma.j.issn.0254-6450.2016.02.011

KeyWord: 人类免疫缺陷病毒基因型耐药警戒线调查抗病毒治疗

English Key Word: Human immunodeficiency virus Genotype Drug resistance threshold survey Antiretroviral therapy

FundProject:国家科技重大专项(2012ZX10001-002)

Author Name	Affiliation	E-mail
Chen Min	Institute for AIDS/STDs Control and Prevention, Yunnan Provincial Center for Disease Control and Prevention, Kunming 650022, China
Wang Jibao	Department of AIDS/STDs Control and Prevention, Dehong Center for Disease Control and Prevention, Mangshi 678400, China
Xing Hui	Division of Research on Virology and Immunology, National Center for AIDS/STD Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 102206, China
Ma Yanling	Institute for AIDS/STDs Control and Prevention, Yunnan Provincial Center for Disease Control and Prevention, Kunming 650022, China
Yang Jin	Department of AIDS/STDs Control and Prevention, Dehong Center for Disease Control and Prevention, Mangshi 678400, China
Chen Huichao	Institute for AIDS/STDs Control and Prevention, Yunnan Provincial Center for Disease Control and Prevention, Kunming 650022, China
Yao Shitang	Department of AIDS/STDs Control and Prevention, Dehong Center for Disease Control and Prevention, Mangshi 678400, China
Luo Hongbing	Institute for AIDS/STDs Control and Prevention, Yunnan Provincial Center for Disease Control and Prevention, Kunming 650022, China
Duan Xing	Department of AIDS/STDs Control and Prevention, Dehong Center for Disease Control and Prevention, Mangshi 678400, China
Wang Yikui	Department of AIDS/STDs Control and Prevention, Dehong Center for Disease Control and Prevention, Mangshi 678400, China
Duan Song	Department of AIDS/STDs Control and Prevention, Dehong Center for Disease Control and Prevention, Mangshi 678400, China	dhduansong@sina.com
Jia Manhong	Institute for AIDS/STDs Control and Prevention, Yunnan Provincial Center for Disease Control and Prevention, Kunming 650022, China	jiamanhong@hotmail.com

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Abstract:

目的调查2014年云南省德宏州未经抗病毒治疗的HIV感染者的耐药株传播水平。方法 2014年1-8月在德宏州收集70份新报告的16~25岁HIV-1感染者的血浆样品,对符合耐药警戒线调查要求的58份样品进行HIV-1基因型耐药检测和耐药株传播水平分析。结果 50份样品完成了基因型及耐药鉴定,中国籍占34.0%,缅甸籍占66.0%。通过进化分析对pol区进行分型,主要的基因型包括CRF01_AE、C亚型、URFs、CRF62_BC、CRF08_BC、CRF07_BC、CRF64_BC、B亚型和CRF55_01B,分别占28.0%、20.0%、20.0%、10.0%、8.0%、4.0%、4.0%、4.0%和2.0%。在1个序列中检测到1个针对蛋白酶抑制剂类药物的耐药突变位点(M46I),按照耐药警戒线的统计方法估算耐药株流行率<5%。结论德宏州16~25岁新报告的HIV-1感染人群中外籍比例较高,HIV新型重组开始传播,但HIV-1耐药性传播尚处于低度水平。

English Abstract:

Objective To study the HIV-1 genotypes and transmitted drug resistance(TDR) in Dehong prefecture of Yunnan province in 2014.Methods A total of 70 plasma samples of recently reported HIV-infected individuals between 16 and 25 years old were collected in Dehong prefecture from January to August 2014.Among them, 58 samples which met the criterion of HIV drug resistance threshold survey(HIVDR-TS) were subjected to genetic drug resistance detection.Results 50 plasma samples were successfully sequenced and analyzed.Among them, 34.0% were Chinese and 66.0% were Burmese.Based on pol sequences, all the identified HIV genotypes would include CRF01_AE(28.0%), subtype C(20.0%), URF(20.0%), CRF62_BC(10.0%), CRF08_BC(8.0%), CRF07_BC(4.0%), CRF64_BC(4.0%), subtype B(4.0%) and CRF55_01B(2.0%).One drug, which resistant mutation to proteinase inhibitors had been detected in one sequence.Based on the statistical method of HIVDR-TS, the prevalence of transmitted HIV-1 drug resistance was adjusted as<5%.Conclusion The proportion of Burmese was relatively higher among those newly reported HIV-infected individuals aged 16 to 25 in Dehong.We noticed that the novel circulating recombinant forms began to function.However, the level of transmission through HIV-1 drug resistant strains still kept low in Dehong.

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