| 刘文羽,卫飞雪,唐杰,杨尚波,高亚春,王婷,姜允飞,李梅,洪颖,储凯,陈汶,胡月梅,朱凤才.江苏省阜宁地区自然人群中18~45岁女性人乳头瘤病毒16、18型中和抗体及DNA的流行率[J].Chinese journal of Epidemiology,2016,37(3):406-409 |
| 江苏省阜宁地区自然人群中18~45岁女性人乳头瘤病毒16、18型中和抗体及DNA的流行率 |
| Detection of neutralizing antibodies and DNA of human papillomavirus 16, 18 in women aged 18-45 years in Funing, Jiangsu province |
| Received:August 27, 2015 |
| DOI：10.3760/cma.j.issn.0254-6450.2016.03.024 |
| KeyWord: 人乳头瘤病毒 中和抗体 假病毒中和试验 基因型别 患病率 |
| English Key Word: Human papillomavirus Neutralizing antibody Pseudovirion-based neutralization assay Genotype Prevalence |
| FundProject:福建省科技创新平台建设计划项目(2014Y2004) |
| Author Name | Affiliation | E-mail | | Liu Wenyu | Funing County Center for Disease Control and Prevention of Jiangsu Province, Funing 224400, China | | | Wei Feixue | State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, National Institute of Diagnostics and Vaccine Development in Infectious Diseases, School of Public Health, Xiamen University, Xiamen 361100, China | | | Tang Jie | Funing County Center for Disease Control and Prevention of Jiangsu Province, Funing 224400, China | | | Yang Shangbo | Funing County Center for Disease Control and Prevention of Jiangsu Province, Funing 224400, China | | | Gao Yachun | Funing County Center for Disease Control and Prevention of Jiangsu Province, Funing 224400, China | | | Wang Ting | Funing County Center for Disease Control and Prevention of Jiangsu Province, Funing 224400, China | | | Jiang Yunfei | The Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing 210008, China | | | Li Mei | The Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing 210008, China | | | Hong Ying | The Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing 210008, China | | | Chu Kai | Jiangsu Provincial Center for Disease Control and Prevention, Nanjing 210009, China | | | Chen Wen | Cancer Institute and Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China | | | Hu Yuemei | Jiangsu Provincial Center for Disease Control and Prevention, Nanjing 210009, China | huyuemei@hotmail.com | | Zhu Fengcai | Jiangsu Provincial Center for Disease Control and Prevention, Nanjing 210009, China | |
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| Abstract: |
| 目的 研究江苏省阜宁地区自然人群中18~45岁女性人乳头瘤病毒(HPV)16、18型中和抗体及DNA的分布。方法 2012年12月至2013年1月,采用多阶段随机抽样的方法,在江苏省阜宁地区共招募1 494名18~45岁女性,采集宫颈脱落细胞进行HPV DNA检测,采集血清并通过假病毒中和试验检测抗HPV16、18型中和抗体,采用SPSS 21.0软件分析不同年龄段HPV DNA阳性率及HPV中和抗体阳性率的差异。结果 1 494名女性中HPV16型 DNA阳性28例(1.9%)、中和抗体阳性188例(12.6%);HPV18型 DNA阳性15例(1.0%)、中和抗体阳性60例(4.0%)。HPV16、18型 DNA和中和抗体阳性率在各年龄段的分布差异均无统计学意义(P>0.05)。16.7%的研究对象已感染过HPV16和/或18型。结论 江苏省阜宁地区自然人群中18~45岁女性大多数未感染过HPV16、18型,是HPV16、18型疫苗应用的目标人群。 |
| English Abstract: |
| Objective To understand the distributions of DNA and neutralizing antibodies of human papillomavirus (HPV)16, 18 in 18-45 year-old women. Methods Totally, 1 494 women were enrolled through multistage random sampling in Funing, Jiangsu province. Cervical exfoliated cells were collected from them for HPV DNA testing, and serum samples were taken from them for the detection of HPV16, 18 neutralizing antibodies by using pseudovirion-based neutralization assay (PBNA). Results Among the 1 494 women, 28(1.9%) and 188(12.6%) were positive for DNA and neutralizing antibody of HPV16 respectively, and 15(1.0%) and 60(4.0%) were positive for DNA and neutralizing antibody of HPV18, respectively. There were no significant differences in the detection rates of DNA and neutralizing antibody of HPV16, 18 among different age groups. About 16.7% of the women were infected with HPV16, 18, or both. Conclusion In Funing county of Jiangsu province, most women aged 18-45 years has no immunity to HPV16 and 18, indicating that they are appropriate targets for HPV 16/18 vaccination. |
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