中国18岁以下双生子出生体重与超重/肥胖的关联分析

刘青青; 余灿清; 高文静; 曹卫华; 吕筠; 王胜锋; 逄增昌; 丛黎明; 董忠; 吴凡; 汪华; 吴先萍; 王德征; 王滨有; 李立明

Abstract

刘青青,余灿清,高文静,曹卫华,吕筠,王胜锋,逄增昌,丛黎明,董忠,吴凡,汪华,吴先萍,王德征,王滨有,李立明.中国18岁以下双生子出生体重与超重/肥胖的关联分析[J].Chinese journal of Epidemiology,2016,37(4):464-468

中国18岁以下双生子出生体重与超重/肥胖的关联分析

A co-twin control study on birth weight, overweight and obesity among children younger than 18 years old in China

Received:September 06, 2015

DOI：10.3760/cma.j.issn.0254-6450.2016.04.005

KeyWord: 超重/肥胖出生体重双生子对内对照设计

English Key Word: Overweight and obesity Birth weight Co-twin control study

FundProject:卫生行业科研专项项目(201002007);教育部科学技术研究项目重大项目(310006)

Author Name	Affiliation	E-mail
Liu Qingqing	Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing 100191, China
Yu Canqing	Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing 100191, China
Gao Wenjing	Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing 100191, China
Cao Weihua	Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing 100191, China
Lyu Jun	Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing 100191, China
Wang Shengfeng	Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing 100191, China
Pang Zengchang	Qingdao Center for Disease Control and Prevention, Qingdao 266033, China
Cong Liming	Zhejiang Provincial Center for Disease Control and Prevention, Hangzhou 310051, China
Dong Zhong	Department of Chronic and Non-communicable Disease Control and Prevention, Beijing Center for Disease Control and Prevention, Beijing 100013, China
Wu Fan	Shanghai Center for Disease Control and Prevention, Shanghai 200336, China
Wang Hua	Jiangsu Provincial Center for Disease Control and Prevention, Nanjing 210009, China
Wu Xianping	Sichuan Provincial Center for Disease Control and Prevention, Chengdu 610041, China
Wang Dezheng	Department of Chronic and Non-communicable Disease Control and Prevention, Tianjin Center for Disease Control and Prevention, Tianjin 300011, China
Wang Binyou	Department of Epidemiology, School of Public Health, Harbin Medical University, Harbin 150081, China
Li Liming	Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing 100191, China	lmlee@vip.163.com

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Abstract:

目的分析出生体重与儿童时期超重/肥胖间的关联。方法使用中国双生子登记系统基线调查的<18岁双生子人群(共8267对),采用双生子对内对照设计方法,探索出生体重与儿童青少年时期BMI及超重/肥胖之间的关联。结果调整性别和卵型的影响后,出生体重每增加0.5 kg,超重/肥胖的风险:幼儿及学龄前期(≥ 2且<6岁)儿童增加0.87倍,学龄期(≥ 6且<12岁)儿童增加0.69倍,青春期(≥ 12且<18岁)青少年增加0.28倍。结论双生子出生体重与幼儿及学龄期超重/肥胖存在正向关联,但在指导实施公共卫生干预措施时仍需谨慎。

English Abstract:

Objective To analyze the associations between birth weight and overweight/obesity among children. Methods A total of 8267 twin pairs younger than 18 years old from the Chinese National Twin Registry were included in the study. Associations between birth weight, childhood BMI and overweight/obesity were explored by this co-twin control study. Results After adjusting for sex and zygosity, when birth weight had an increase of 0.5 kg per fold, the OR values for overweight and obesity were 1.87(95%CI:1.40-2.48) for 2-6 year olds, 1.69(95%CI:1.16-2.46) for 6-12 year olds and 1.28(95%CI:0.80-2.07) for 12-18 year olds. Results from the stratified analysis in the 2-6 year-olds, statistically significant differences were seen. When birth weight increased 0.5 kg per fold, the risk of overweight and obesity increased by 0.87 times among the dizygotic twins, more than that of the monozygotic twins(OR=1.86, 95%CI:1.24-2.81). The risk for male twins was 1.12 times higher than that of female twins(OR=1.65, 95%CI:1.11-2.44). Conclusions Birth weight seemed associated with overweight and obesity for kids at early childhood or at age for schools. However, guidance on the implementation of public health interventions is still needed on these children.

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