| 陈明珠,黄鹏,陈红波,姚轶男,彭志行,喻荣彬.江苏某地区既往有偿献血人群HCV感染状况及相关因素研究[J].Chinese journal of Epidemiology,2016,37(5):653-657 |
| 江苏某地区既往有偿献血人群HCV感染状况及相关因素研究 |
| HCV infection status and risk factors in remunerated blood donors in Jiangsu province |
| Received:December 21, 2015 |
| DOI：10.3760/cma.j.issn.0254-6450.2016.05.013 |
| KeyWord: 丙型肝炎病毒 有偿献血 反转录病毒 危险因素 |
| English Key Word: Hepatitis C virus Paid blood donors RNA Risk factors |
| FundProject:国家自然科学基金面上项目(81473029);江苏省卫生厅医改科研项目(YG201413);镇江市科技计划(社发科技支撑)(SH20141);江苏高校优势学科建设工程资助(PAPD) |
| Author Name | Affiliation | E-mail | | Chen Mingzhu | Department of Epidemiology, School of Public Health, Nanjing Medical University, Nanjing 211166, China | | | Huang Peng | Department of Epidemiology, School of Public Health, Nanjing Medical University, Nanjing 211166, China | | | Chen Hongbo | Department of Infectious Diseases, the Jurong People's Hospital, Jurong 212400, China | | | Yao Yinan | Department of Epidemiology, School of Public Health, Nanjing Medical University, Nanjing 211166, China | | | Peng Zhihang | Department of Epidemiology, School of Public Health, Nanjing Medical University, Nanjing 211166, China | | | Yu Rongbin | Department of Epidemiology, School of Public Health, Nanjing Medical University, Nanjing 211166, China | rongbinyu@njmu.edu.cn |
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| Abstract: |
| 目的 探索江苏某地区既往有偿献血人群HCV感染的流行状况,分析与HCV感染转归及HCV RNA载量相关的因素。方法 对该地区50岁以上人群开展横断面研究,采用问卷方式收集研究对象信息,并对其进行肝脏B超检查及相关指标检查。应用EpiData和Stata软件对数据进行录入及统计学分析。结果 该地区1601名50岁以上人群中HCV感染率为22.55%,516名既往有偿献血人群HCV感染率为61.05%。多元逐步回归显示, ALT及AST与HCV感染转归之间存在相关性,OR值分别为1.38(95%CI:1.18~1.62)及1.30(95%CI:1.10~1.54)。FPG与HCV RNA病毒载量之间存在相关性(OR=1.17,95%CI:1.01~1.35)。结论 该地区HCV感染率较高,临床上ALT、AST以及FPG的检测结果与HCV的感染转归风险及病毒活动能力之间存在关联。 |
| English Abstract: |
| Objective To investigate the infection status of HCV in remunerated blood donors and risk factors in Jiangsu province. Methods A Cross-sectional study was conducted among people aged >50 years. Questionnaires were used to collect the information about their demographic characteristics and risk behaviors, and venous blood samples were collected from them to detect HCV anti-body, HCV-RNA and other biochemical indicators. EpiData and Stata were used for data entry and statistical analysis. Results The overall HCV sero-prevalence rates were 22.55% and 61.05% among remunerated blood donors. Data from multiple stepwise regression analysis showed that alanine aminotransferase (ALT) (adjusted OR=1.38, 95%CI:1.18-1.62) and aspartate aminotransferase (AST) (adjusted OR=1.30, 95%CI:1.10-1.54) were associated with the outcomes of HCV infection, and fasting plasma glucose (adjusted OR=1.17, 95%CI:1.01-1.35) were associated with HCV RNA viral loads. Conclusion The prevalence of HCV infection in remunerated blood donors was high, clinical ALT, AST and fasting plasma glucose levels were associated with the risk for HCV infection and HCV RNA viral load. |
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