中国人群2型糖尿病影响因素的Meta分析

周婷; 刘祥; 李晓松; 刘元元

Abstract

周婷,刘祥,李晓松,刘元元.中国人群2型糖尿病影响因素的Meta分析[J].Chinese journal of Epidemiology,2016,37(5):730-736

中国人群2型糖尿病影响因素的Meta分析

Influencing factors of type 2 diabetes mellitus in Chinese:a Meta-analysis

Received:September 25, 2015

DOI：10.3760/cma.j.issn.0254-6450.2016.05.030

KeyWord: 糖尿病,2型影响因素系统评价 Meta分析

English Key Word: Type 2 diabetes mellitus Influencing factor Systematic review Meta-analysis

FundProject:美国中华医学基金会四川大学合作中心项目(12-106);四川大学青年教师科研启动基金(2014SCU11035)

Author Name	Affiliation	E-mail
Zhou Ting	Department of Epidemiology and Health Statistics, West China School of Public Health, Sichuan University, Chengdu 610041, China
Liu Xiang	Department of Health-related Social and Behavioral Sciences, West China School of Public Health, Sichuan University, Chengdu 610041, China
Li Xiaosong	Department of Epidemiology and Health Statistics, West China School of Public Health, Sichuan University, Chengdu 610041, China
Liu Yuanyuan	Department of Epidemiology and Health Statistics, West China School of Public Health, Sichuan University, Chengdu 610041, China	y_multi@126.com

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Abstract:

目的探讨中国人群2型糖尿病患病影响因素。方法检索PubMed、Medline、Science Direct、EBSCO、CBM、CNKI、VIP和万方科技文献数据库,收集1997年1月至2015年5月有关中国糖尿病影响因素的文献。根据纳入排除标准筛选文献并对纳入文献进行质量评价、资料提取,并采用RevMan 4.4.2软件进行Meta分析。结果共纳入29篇文献,研究对象总计92970(病例组11150,对照组81820)例。超重、中心性肥胖、糖尿病家族史、吸烟、饮酒、高血压、SBP、高脂血症、TC、TG、冠心病史、脑血管意外史、食用油类型合并OR值及其95%CI分别为1.66(1.49~1.85)、1.98(1.31~3.01)、3.13(2.52~3.87)、1.46(1.24~1.72)、1.19(1.09~1.29)、2.64(2.23~3.13)、1.15(1.06~1.24)、2.26(1.75~2.92)、1.87(1.14~3.08)、1.73(1.23~2.44)、2.55(1.78~3.65)、2.21(1.62~3.02)、0.52(0.27~0.99)。亚组分析提示3个时段共有影响因素为超重、糖尿病家族史、吸烟和高血压。结论超重、中心性肥胖、糖尿病家族史、吸烟、饮酒、高血压、SBP、高脂血症、TC、TG、冠心病史、脑血管意外史和食用油类型是2型糖尿病的影响因素,近20年超重、糖尿病家族史、吸烟和高血压持续影响,而超重/肥胖可能更应关注。

English Abstract:

Objective To evaluate the influencing factors of type 2 diabetes mellitus in Chinese, and provide evidence for developing health promotion policy in the future. Methods Relevant studies published from January 1997 to May 2015 were retrieved from PubMed, Medline, EBSCO, Science Direct, CBM, CNKI, VIP, and Wanfang Database. Quality evaluation of the included literatures was conducted according to the inclusion and exclusion criteria, followed by data extraction and Meta-analysis with software RevMan 4.4.2. Results A total of 29 studies involving 92 970 subjects (11 150 cases and 81 820 controls) were included. The pooled OR and its 95%CI of each influencing factor were:overweight OR=1.66 (1.49-1.85), abdominal obesity OR=1.98 (1.31-3.01), family history of diabetes OR=3.13 (2.52-3.87), smoking OR=1.46 (1.24-1.72), drinking OR=1.19 (1.09-1.29), hypertension OR=2.64 (2.23-3.13), systolic blood pressure (SBP) OR=1.15(1.06-1.24), hyperlipoidemia OR=2.26 (1.75-2.92), total cholesterol (TC) OR=1.87 (1.14-3.08), triglyceride (TG) OR=1.73 (1.23-2.44), history of coronary heart disease (CHD) OR=2.55 (1.78-3.65), cerebrovascular accident (CVA) OR=2.21 (1.62-3.02), dietary fat OR=0.52 (0.27-0.99). The results of subgroup analysis identified 4 common influencing factors shared by the three subgroups, i.e. overweight, family history of diabetes, smoking and hypertension. Conclusion Overweight, abdominal obesity, family history of diabetes, smoking, drinking, hypertension, SBP, TC, TG, history of CHD, history of CVA, and subtypes of dietary fat are the influencing factors for type 2 diabetes mellitus in Chinese. Among these factors, overweight in recent 20 years, family history of diabetes, smoking and hypertension are persistent factors. More attention should be paid to overweight and obesity.

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