| 陈宇,米白冰,赵亚玲,杨姣梅,陶雅丽,颜虹.孕期室外空气污染与早产关系的Meta分析[J].Chinese journal of Epidemiology,2016,37(6):880-885 |
| 孕期室外空气污染与早产关系的Meta分析 |
| Prenatal exposure to outdoor air pollution and preterm birth:a Meta-analysis |
| Received:October 26, 2015 |
| DOI：10.3760/cma.j.issn.0254-6450.2016.06.028 |
| KeyWord: 空气污染 早产 暴露时期 Meta分析 |
| English Key Word: Air pollution Preterm birth Periods of exposure Meta-analysis |
| FundProject:国家自然科学基金(81230016) |
| Author Name | Affiliation | E-mail | | Chen Yu | Department of Epidemiology and Biostatistics, School of Public Health, Health Science Center of Xi'an Jiaotong University, Xi'an 710061, China | | | Mi Baibing | Department of Epidemiology and Biostatistics, School of Public Health, Health Science Center of Xi'an Jiaotong University, Xi'an 710061, China | | | Zhao Yaling | Department of Epidemiology and Biostatistics, School of Public Health, Health Science Center of Xi'an Jiaotong University, Xi'an 710061, China | | | Yang Jiaomei | Department of Epidemiology and Biostatistics, School of Public Health, Health Science Center of Xi'an Jiaotong University, Xi'an 710061, China | | | Tao Yali | Department of Epidemiology and Biostatistics, School of Public Health, Health Science Center of Xi'an Jiaotong University, Xi'an 710061, China | | | Yan Hong | Department of Epidemiology and Biostatistics, School of Public Health, Health Science Center of Xi'an Jiaotong University, Xi'an 710061, China | xjtu_yh.paper@aliyun.com |
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| Abstract: |
| 目的 探讨孕期室外空气污染与早产的关系,为减少早产的发生提供循证医学证据。方法 收集国内外已发表的有关孕期空气污染与早产关系的病例对照研究,采用Stata 12.0软件进行Meta分析。结果 共纳入10篇文献,包括病例48556例,对照548495例。Meta分析显示,整个孕期二氧化氮(NO2)、PM10、一氧化碳(CO)、PM2.5、氮氧化物(NO)暴露与早产的合并效应OR值分别为0.960(95%CI:0.935~0.985)、1.068(95%CI:1.035~1.103)、1.122(95%CI:1.078~1.168)、1.110(95%CI:1.043~1.181)、0.994(95%CI:0.973~1.016)。空气污染物NO2、PM10、二氧化硫(SO2)暴露时期不同对早产的影响不同,在孕早期暴露其合并效应OR值分别为1.117(95%CI:1.052~1.186)、0.968(95%CI:0.812~1.153)、1.258(95%CI:0.758~2.089);孕中期暴露其合并效应OR值分别为1.000(95%CI:0.982~1.019)、1.127(95%CI:0.896~1.416)、0.977(95%CI:0.711~1.342);孕晚期暴露其合并效应OR值分别为1.006(95%CI:1.002~1.010)、1.053(95%CI:0.973~1.139)、1.003(95%CI:1.000~1.006)。结论 整个孕期暴露于PM10、CO和PM2.5,孕早期暴露于NO2,孕晚期暴露于NO2和SO2可能与早产的发生有关。 |
| English Abstract: |
| Objective To assess the association between exposure to prenatal outdoor air pollution and preterm birth to provide evidence in setting up programs for prevention on premature birth. Methods Case-control studies regarding association between pregnant exposure to outdoor air pollution and preterm birth were collected. Data were analyzed with Stata 12.0. Results Ten articles including 48 556 cases and 548 495 controls were qualified for inclusion. Results from Meta-analyses showed pooled ORs for exposure to NO2, PM10, CO, PM2.5, and NO during the entire pregnancy were 0.960 (95%CI:0.935-0.985), 1.068 (95%CI:1.035-1.103), 1.122 (95%CI:1.078-1.168), 1.110 (95%CI:1.043-1.181) and 0.994 (95%CI:0.973-1.016). Association between air pollution and preterm birth varied with the periods of exposure. Pooled ORs for NO2, PM10 and SO2 exposure during the first trimester were 1.117 (95%CI:1.052-1.186), 0.968 (95%CI:0.812-1.153) and 1.258 (95%CI:0.758-2.089). Pooled ORs for NO2, PM10, SO2 exposure during the second trimester were 1.000 (95%CI:0.982-1.019), 1.127 (95%CI:0.896-1.416) and 0.977 (95%CI:0.711-1.342). Pooled ORs for NO2, PM10, SO2 exposure during the third trimester were 1.006 (95%CI:1.002-1.010), 1.053 (95%CI:0.973-1.139) and 1.003 (95%CI:1.000-1.006). Conclusion Exposures to PM10, CO and PM2.5 during the entire pregnancy, to NO2 during the first trimester, or to NO2 and SO2 during the third trimester were associated with preterm births. |
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