| 高莹,高文静,曹卫华.儿童青少年肥胖与DNA甲基化关联研究进展[J].Chinese journal of Epidemiology,2016,37(8):1169-1174 |
| 儿童青少年肥胖与DNA甲基化关联研究进展 |
| Current status and progress in studies on the association between obesity and DNA methylation among children and adolescents |
| Received:January 21, 2016 |
| DOI：10.3760/cma.j.issn.0254-6450.2016.08.023 |
| KeyWord: 肥胖 DNA甲基化 表观遗传学 儿童青少年 |
| English Key Word: Obesity DNA methylation Epigenetics Children and adolescents |
| FundProject:国家自然科学基金（81473041） |
| Author Name | Affiliation | E-mail | | Gao Ying | Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing 100191, China | | | Gao Wenjing | Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing 100191, China | | | Cao Weihua | Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing 100191, China | caoweihua60@163.com |
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| Abstract: |
| DNA甲基化是目前研究最常见的表观遗传现象，有助于从生物学机制上解释遗传因素、环境因素及基因-环境因素交互作用对于肥胖的影响。生命早期DNA甲基化研究对于预防和控制肥胖具有重要作用，国内此方面研究尚缺乏。本研究通过回顾儿童青少年肥胖与DNA甲基化关联研究现状，介绍DNA甲基化研究的主要原理、基本特点及其与肥胖关联研究的主要结果，为今后相关研究提供依据。 |
| English Abstract: |
| DNA methylation is one of the most commonly recognized epigenetic phenomenon, which explains how genes, environmental factors and gene-environment interaction would cause obesity, integretedly. Studies on early life obesity-related epigenetic reveal important effects that related to the programs on prevention and control of obesity. However, only few similar studies have been conducted in China. This paper summarizes the basic principles, characteristics of DNA methylation and the major results of children and adolescents obesity-related research areas, in order to provide evidence for further studies. |
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