中国60岁及以上人群老年期痴呆患病率Meta分析

刘伯源; 王久玲; 肖义泽

Abstract

刘伯源,王久玲,肖义泽.中国60岁及以上人群老年期痴呆患病率Meta分析[J].Chinese journal of Epidemiology,2016,37(11):1541-1545

中国60岁及以上人群老年期痴呆患病率Meta分析

Prevalence of senile dementia in people aged ≥60 years in China: a Meta-analysis

Received:April 20, 2016

DOI：10.3760/cma.j.issn.0254-6450.2016.11.021

KeyWord: 老年期痴呆阿尔茨海默病患病率 Meta分析

English Key Word: Senile dementia Alzheimer's disease Prevalence Meta-analysis

FundProject:

Author Name	Affiliation	E-mail
Liu Boyuan	School of Public Health, Kunming Medical University, Kunming 650500, China
Wang Jiuling	School of Public Health, Kunming Medical University, Kunming 650500, China
Xiao Yize	Institute for Chronic and Non-communicable Disease Prevention and Control, Yunnan Provincial Center for Disease Control and Prevention, Kunming 650022, China	xyz6292@sina.com

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Abstract:

目的探讨2000-2015年中国≥60岁人群老年期痴呆患病率情况。方法通过系统检索中国知网数据库、万方数据库、维普中文科技期刊数据库和PubMed等中英文数据库中有关老年期痴呆患病率的研究文献，检索时间为2000-2015年。采用R软件进行Meta分析。结果共纳入25篇文献，总调查人数为76 980人，其中患者4 295例；经Meta分析，老年期痴呆患病率为5.15%（95%CI：4.21%～6.09%）；亚组分析显示，老年期痴呆患病率女性（6.08%）高于男性（4.10%），年龄越大者患病率越高（60～64岁至≥85岁年龄人群老年期痴呆患病率从1.01%升至23.60%），阿尔茨海默病患病率（3.56%）高于脑血管性痴呆患病率（1.11%），文盲人群患病率（8.74%）高于非文盲人群（3.17%），非在婚人群患病率（6.83%）高于在婚人群（3.95%）。结论中国≥60岁人群老年期痴呆患病率较高，年龄、性别、文化水平和婚姻状况可能影响老年期痴呆的发生。

English Abstract:

Objective To understand the prevalence of senile dementia in the elderly aged ≥60 years in China between 2000 and 2015. Methods Publications between 2000 and 2015 were retrieved from China National Knowledge Infrastructure (CNKI), Wanfang Databases, Chinese Science and Technology Journal Databases (VIP) and PubMed. Observational studies on prevalence of senile dementia were included. Meta-analysis was carried out by using R software. Results A total of 25 papers were included in this study. The total number of participants investigated was 76 980, with 4 295 dementia cases identified. The prevalence of senile dementia in the elderly was 5.15% (95%CI: 4.21%-6.09%); Subgroup analysis showed that the women had a higher prevalence (6.08%) than the men (4.10%); and the prevalence was significant increased with age (The senile dementia prevalence was 1.01% in age groups 60-64 years, but 23.60% in age group ≥85 years). The prevalence of Alzheimer's disease (3.56%) was higher than that of cerebral vascular dementia (1.11%). The senile dementia prevalence in the illiterate was 8.74%, higher than 3.17% in the literate. The prevalence of senile dementia in the unmarried was 6.83%, higher than that in the married (3.95%). Conclusion The prevalence of senile dementia was high in the population aged ≥60 years in China. Age, sex, education level and marital status might influence the prevalence of senile dementia.

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