慢性阻塞性肺疾病遗传易感性研究进展

王梦莹; 刘冬静; 黄辉; 吴涛; 曹卫华; 李立明

Abstract

王梦莹,刘冬静,黄辉,吴涛,曹卫华,李立明.慢性阻塞性肺疾病遗传易感性研究进展[J].Chinese journal of Epidemiology,2016,37(12):1678-1682

慢性阻塞性肺疾病遗传易感性研究进展

A review on the genetic risk factors of chronic obstructive pulmonary disease

Received:July 12, 2016

DOI：10.3760/cma.j.issn.0254-6450.2016.12.023

KeyWord: 慢性阻塞性肺疾病遗传易感因素

English Key Word: Chronic obstructive pulmonary disease Genetic risk factors

FundProject:

Author Name	Affiliation	E-mail
Wang Mengying	Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing 100191, China
Liu Dongjing	Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing 100191, China
Huang Hui	Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing 100191, China
Wu Tao	Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing 100191, China	twu@bjmu.edu.cn
Cao Weihua	Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing 100191, China
Li Liming	Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing 100191, China

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Abstract:

慢性阻塞性肺疾病（COPD）是一种常见的慢性非传染性疾病，以不完全可逆的气流受限呈进行性发展为特征。COPD患病率和死亡率均较高，造成的疾病负担严重。COPD存在个体易感性，遗传因素在COPD的发生中发挥重要作用，但大部分遗传因素与COPD之间的关联存在不一致性。本文对COPD遗传易感因素的研究进展进行综述。

English Abstract:

Chronic obstructive pulmonary disease (COPD) refers to a common complex disease characterized by progressive and incomplete reversible airflow limitation. COPD is one of the leading causes on morbidity and mortality in China. Genetic risk factors play important roles on the occurrence of COPD. However, the genetic risk factors of COPD remain unknown, to some extent. The aim of this review is to provide a comprehensive overview on literature concerning the most promising findings related to genetic risk factors of COPD.

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