| 谢双华,王刚,郭兰伟,陈朔华,苏凯,李放,昌盛,冯小双,吕章艳,陈玉恒,任建松,崔宏,李霓,吴寿岭,代敏,赫捷.腰围与男性肺癌发病关系的前瞻性队列研究[J].Chinese journal of Epidemiology,2017,38(2):137-141 |
| 腰围与男性肺癌发病关系的前瞻性队列研究 |
| Relation between waist circumference and risk of male lung cancer incidence: a prospective cohort study |
| Received:August 01, 2016 |
| DOI：10.3760/cma.j.issn.0254-6450.2017.02.001 |
| KeyWord: 肺肿瘤 男性 腰围 队列研究 前瞻性研究 |
| English Key Word: Lung neoplasms Men Waist circumference Cohort studies Prospective studies |
| FundProject:2014年公益性行业科研专项（201402003）；北京市科技新星计划（xx2012067）；北京协和医学院协和青年基金（33320140168） |
| Author Name | Affiliation | E-mail | | Xie Shuanghua | National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China | | | Wang Gang | Kailuan General Hospital, Tangshan 063000, China | | | Guo Lanwei | National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China | | | Chen Shuohua | Kailuan General Hospital, Tangshan 063000, China | | | Su Kai | National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China | | | Li Fang | National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China | | | Chang Sheng | National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China | | | Feng Xiaoshuang | National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China | | | Lyu Zhangyan | National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China | | | Chen Yuheng | National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China | | | Ren Jiansong | National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China | | | Cui Hong | National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China | | | Li Ni | National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China | nli@cicams.ac.cn | | Wu Shouling | Kailuan General Hospital, Tangshan 063000, China | | | Dai Min | National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China | daimin2002@hotmail.com | | He Jie | National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China | |
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| Abstract: |
| 目的 探讨腰围与男性肺癌发病风险的关系。方法 以开滦集团全体在职及离退休男性职工为调查对象，自2006年5月建立开滦集团男性动态队列并随访。基线调查时收集研究对象身高、体重、腰围等信息，并在随访时收集结局事件信息。腰围按五分位数进行分组：<80、80~、85~、90~、≥95 cm，并以腰围80~cm组为参比组，采用多因素Cox比例风险回归模型分析腰围与男性肺癌发病的风险比（HR）和95%CI。结果 截止2014年12月31日，共有105 386名研究对象进入队列，共随访739 651.13人年，平均随访7.00年，共收集肺癌新发病例707例。以80~cm组为参比组，调整年龄、文化程度、吸烟状态、累计吸烟量、饮酒情况、体育锻炼、工作环境、糖尿病史后，腰围<80及85~、90~、≥95 cm组发生肺癌的HR值（95%CI）分别为1.17（0.90~1.52）及0.96（0.74~1.23）、0.94（0.72~1.21）、0.80（0.63~1.03），趋势检验P=0.005。按吸烟、饮酒状态分层分析显示，腰围与肺癌发病风险在吸烟（腰围≥95 cm组与80~cm组相比：HR=0.69，95%CI：0.48~0.99）、饮酒（腰围≥95 cm组与80~cm组相比：HR=0.65，95%CI：0.45~0.94）者中呈负相关。结论 腰围可能与男性肺癌的发病风险之间有负相关关系。 |
| English Abstract: |
| Objective To investigate the association between waist circumference and risk of male lung cancer incidence. Methods Since May 1, 2006, all the male employees including the retirees in Kailuan Group had been recruited into a Chinese Kailuan Male Cohort study. Information on anthropometries including body weight, height and waist circumference were collected at the baseline investigation, as well as information on newly-diagnosed lung cancer cases during the follow-up period. Waist circumference was grouped by quintiles of the population waist circumference distribution and categorized into the following five groups:<80, 80-, 85-, 90- and ≥95 cm, with the relevant normal group, the second quintile group (80- cm), serving as the referent category. Multivariable Cox proportional hazards regression models were used to evaluate the association between levels of waist circumference and risk of lung cancer. Results A total of 105 386 males were recruited in the study, with 739 651.13 person-years of follow-up and an average follow-up period of 7.00 years. By the end of 2014, a total of 707 lung cancer cases were identified in the cohort study. Compared with males having the 80- cm of waist circumference, the hazard ratio (HR) and 95% confidence intervals (CI) of lung cancer were 1.17(0.90-1.52), 0.96(0.74-1.23), 0.94(0.72-1.21) and 0.80(0.63-1.03) for the <80, 85-, 90- and ≥95 cm of waist circumference, after adjustment for potential confounding factors including age, education level, smoking status and pack-year amount, alcohol consumption, physical activities, environment for working place and the prevalence on diabetes. The inverse association existed in smokers (≥95 cm compared to 80- cm of waist circumference:HR=0.69, 95%CI:0.48-0.99) and alcohol drinkers (≥95 cm compared to 80- cm of waist circumference:HR=0.65, 95%CI:0.45-0.94) when analysis was conducted in subgroups stratified by smoking or alcohol drinking status. Conclusion Waist circumference might be inversely associated with male lung cancer risk. |
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