| 肖甜,陈晓英,王娜,赵琦,付朝伟,徐飚.中国大城市社区慢性阻塞性肺部疾病患者药物使用现状研究[J].Chinese journal of Epidemiology,2017,38(2):142-146 |
| 中国大城市社区慢性阻塞性肺部疾病患者药物使用现状研究 |
| Study on the situation of drug use in patients with chronic obstructive pulmonary diseases in the Chinese communities of large cities |
| Received:July 26, 2016 |
| DOI：10.3760/cma.j.issn.0254-6450.2017.02.002 |
| KeyWord: 慢性阻塞性肺部疾病 药物使用 社区 横断面研究 |
| English Key Word: Chronic obstructive pulmonary disease Medication Community Cross-sectional study |
| FundProject: |
| Author Name | Affiliation | E-mail | | Xiao Tian | School of Public Health and Key Laboratory of Public Health Safety, Fudan University, Shanghai 200032, China | | | Chen Xiaoying | School of Public Health and Key Laboratory of Public Health Safety, Fudan University, Shanghai 200032, China | | | Wang Na | School of Public Health and Key Laboratory of Public Health Safety, Fudan University, Shanghai 200032, China | | | Zhao Qi | School of Public Health and Key Laboratory of Public Health Safety, Fudan University, Shanghai 200032, China | | | Fu Chaowei | School of Public Health and Key Laboratory of Public Health Safety, Fudan University, Shanghai 200032, China | fcw@fudan.edu.cn | | Xu Biao | School of Public Health and Key Laboratory of Public Health Safety, Fudan University, Shanghai 200032, China | |
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| Abstract: |
| 目的 了解中国大城市社区慢性阻塞性肺部疾病（COPD）患者的用药特征。方法 采用横断面研究设计，在北京、上海、成都和广州市连续募集678名确诊的成年COPD患者。采用统一设计的调查表，由经过统一培训的调查员面对面访问研究对象，同时查阅患者病历卡。采用EpiData 3.1软件建立数据库，统计分析在SAS 9.2软件中完成。结果 近四分之一（26%）的研究对象没有使用任何临床药物的治疗。COPD常用药物使用前三位依次是祛痰止咳剂（50.74%）、磷酸二酯酶抑制剂（49.56%）和白三烯类药物（49.12%）。社区COPD患者的药物组合达36种，其中使用单一药物的患者比例为29.5%（200例），使用2种药物组合的患者比例为39.7%（269例），同时使用3种及以上药物组合的患者比例为30.8%（209例）。此外，研究对象中有36.6%（248例）吸氧。上述特征均与COPD严重程度存在一定的统计学相关。结论 大城市社区COPD患者药物组合较多，用药与推荐指南存在一定差异，今后应加强社区COPD患者药物使用指导与监测。 |
| English Abstract: |
| Objectives To understand the medication being used among patients with chronic obstructive pulmonary diseases (COPD) in Chinese communities of large cities. Methods A cross-sectional survey was carried out in Beijing, Shanghai, Chengdu and Guangzhou with the total number as 678 COPD cases who were continuously recruited. Subjects were face-to-face interviewed using a structured questionnaire and with medical records checked at the same time. All data were double entered into a database under EpiData 3.1, and analyzed by SAS 9.2. Results One quarter of all the subjects did not receive any clinical treatment. The top three drugs for COPD were expectorant (50.74%), phosphodiesterase inhibitors (49.56%), and leukotriene (49.12%). Totally, there were 36 different types combination of drugs used for COPD and the proportions of drugs being used as one, two, and three or more at the same time were 29.5%(200 cases), 39.7%(269 cases) and 30.8%(209 cases) respectively. In addition 36.6%(248 cases) of them used oxygen. There were statistical correlations between drug-use patterns and the severity of COPD. Conclusion The patterns of medication varied over COPD cases in communities from Chinese large cities and appeared differently under the recommendations in the clinical guidelines set for COPD. Guidance and surveillance programs on drugs use for COPD should be improved on patients with COPD in the Chinese communities. |
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