| 朱立国,姜洁,宋词,邹艳,徐建芳,刘红建,彭红,胡志斌,朱凤才,沈洪兵,翟祥军.江苏省2012-2014年HBeAg阳性慢性HBV感染者HBeAg阴转的特征分析[J].Chinese journal of Epidemiology,2017,38(2):179-184 |
| 江苏省2012-2014年HBeAg阳性慢性HBV感染者HBeAg阴转的特征分析 |
| A cohort study on the epidemiological characteristics of HBeAg sero-clearance in HBeAg positive chronic hepatitis B patients in Jiangsu province from 2012 to 2014 |
| Received:August 09, 2016 |
| DOI：10.3760/cma.j.issn.0254-6450.2017.02.009 |
| KeyWord: 肝炎病毒,乙型 乙肝e抗原 阴转 队列 |
| English Key Word: HBV Hepatitis B e antigen Clearance Cohort |
| FundProject:国家科技重大专项（2009ZX10004-904，2011ZX10004-902，2013ZX10004-905）；国家自然科学基金（81502861） |
| Author Name | Affiliation | E-mail | | Zhu Liguo | Major Project Executive Office, Jiangsu Provincial Center for Disease Control and Prevention, Nanjing 210009, China | | | Jiang Jie | Major Project Executive Office, Jiangsu Provincial Center for Disease Control and Prevention, Nanjing 210009, China | | | Song Ci | School of Public Health, Nanjing Medical University, Nanjing 210029, China | | | Zou Yan | Epidemic Prevention Section, Zhangjiagang City Center for Disease Control and Prevention, Zhangjiagang 215600, China | | | Xu Jianfang | Epidemic Prevention Section, Danyang City Center for Disease Control and Prevention, Danyang 212310, China | | | Liu Hongjian | Major Project Executive Office, Taixing City Center for Disease Control and Prevention, Taixing 225400, China | | | Peng Hong | Major Project Executive Office, Jiangsu Provincial Center for Disease Control and Prevention, Nanjing 210009, China | | | Hu Zhibin | Animal Care Facility, Nanjing Medical University, Nanjing 210029, China | | | Zhu Fengcai | Major Project Executive Office, Jiangsu Provincial Center for Disease Control and Prevention, Nanjing 210009, China | | | Shen Hongbing | School of Public Health, Nanjing Medical University, Nanjing 210029, China | | | Zhai Xiangjun | Major Project Executive Office, Jiangsu Provincial Center for Disease Control and Prevention, Nanjing 210009, China | jszxj@jscdc.cn |
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| Abstract: |
| 目的 了解HBeAg阳性慢性HBV感染者发生HBeAg阴转的流行病学特征，为推进慢性HBV感染者的规范管理提供依据。方法 2012-2014年对江苏省传染病防治示范区HBeAg阳性慢性HBV感染者队列开展定期随访。通过Cox回归分析HBeAg阳性慢性HBV感染者HBeAg阴转特征及影响因素，通过重复测量数据方差分析方法分析不同HBeAg转归者HBV DNA的变化趋势。结果 2012年721例HBeAg阳性慢性HBV感染者（平均年龄45.2岁±14.2岁）随访到2014年时393例发生HBeAg阴转，观察1 058人年，HBeAg阴转率为37.2/100人年。有抗病毒治疗史的感染者HBeAg阴转率为32.4/100人年。年长者的HBeAg阴转率较高，从<20岁年龄组的7.0/100人年上升到≥60岁年龄组的62.0/100人年。HBV DNA<2 000 IU/ml的感染者HBeAg阴转率为75.8/100人年，高于≥200 000 IU/ml者的阴转率（16.1/100人年）。通过Cox多元回归分析，相对于HBV DNA<2 000 IU/ml者，HBV DNA≥200 000 IU/ml的感染者HBeAg阴转可能性降低（HR=0.18，95%CI：0.13~0.23，P<0.001）。HBeAg阴转组的HBV DNA较HBeAg持续阳性组下降更快（P<0.001）。结论 HBeAg阳性慢性HBV感染者HBeAg阴转率与年龄和HBV病毒载量有关，对不同特征的HBeAg阳性感染者应采取针对性的管理和干预措施。 |
| English Abstract: |
| Objective To understand the epidemiological characteristics and influencing factors related to HBeAg sero-clearance in chronic hepatitis B patients so as to provide evidence for regular management on chronic HBV patients. Methods From 2012 to 2014, a cohort study was conducted among HBeAg positive chronic HBV patients in Jiangsu province. Association between the characteristics and incidence of HBeAg sero-clearance was analyzed by Cox regression method. The changing trend on HBV DNA between patients with HBeAg sero-clearance and those with persistent HBeAg positive status was compared by repeated measure data variance analysis method. Results In 2012, there were 721 HBeAg positive hepatitis B patients aged (45.2±14.2) years enrolled in this study. By 2014, the follow-up observation period was 1 058 person-years, and 393 cases had lost their HBeAg status, with the rate as 37.2/100 person-years. The HBeAg sero-clearance rate was 32.4/100 person-years in hepatitis B patients who received antiviral treatment. The probability of HBeAg clearance in HBeAg positive hepatitis B patients aged ≥60 year (62.0/100 person-years) was higher than those of aged <20 year (7.0/100 person-years). The rate of HBeAg sero-clearance in HBeAg positive patients with HBV DNA <20 000 IU/ml (75.8/100 person-years) was higher than those whose HBV DNA were ≥200 000 IU/ml (16.1/100 person-years). By Cox regression analysis, the HBV DNA level was an important influencing factor on the progress of HBeAg sero-clearance. Patients with HBV DNA levle as ≥200 000 IU/ml, had a lower HBeAg clearance rate (HR=0.18, 95%CI:0.13-0.23, P<0.001). Compared to the persistent HBeAg positive group, HBV DNA showed a more dramatic fall in the HBeAg-lost group (P<0.001). Conclusion The rate of HBeAg sero-clearance among HBeAg positive hepatitis B patients was correlated with age and HBV DNA status of the patients that called for comprehensive management and intervention programs to develop for the HBeAg positive hepatitis B patients with different characteristics. |
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