新疆喀什地区维吾尔族糖尿病人群血脂异常及控制情况分析

张周斌; 薛振香; 吴雪霁; 王童敏; 利耀辉; 宋雪莲; 晁先锋; 王岗; 乃孜班木·努尔麦麦提; 阿依夏穆姑丽·巴吾顿; 古丽巴哈·艾力亚斯; 周自严; 孙宝山; 王玉忠; 王鸣

Abstract

张周斌,薛振香,吴雪霁,王童敏,利耀辉,宋雪莲,晁先锋,王岗,乃孜班木·努尔麦麦提,阿依夏穆姑丽·巴吾顿,古丽巴哈·艾力亚斯,周自严,孙宝山,王玉忠,王鸣.新疆喀什地区维吾尔族糖尿病人群血脂异常及控制情况分析[J].Chinese journal of Epidemiology,2017,38(6):702-708

新疆喀什地区维吾尔族糖尿病人群血脂异常及控制情况分析

Prevalence of dyslipidemia and normal blood lipids level in Uygur population in Kashgar area of Xinjiang Uygur Autonomous Region

Received:December 21, 2016

DOI：10.3760/cma.j.issn.0254-6450.2017.06.003

KeyWord: 维吾尔族糖尿病血脂异常控制率

English Key Word: Uygur Diabetes,type 2 Dyslipidemia Normal rate

FundProject:国家科技重大专项（2012ZX10004213005）；广东省科技计划项目（2014A020209006）；广州市医学重点学科建设项目（2017-2019-07）

Author Name	Affiliation	E-mail
Zhang Zhoubin	Office of Director, Kashgar Center for Disease Control and Prevention, Kashgar 844100, China
Xue Zhenxiang	844100 喀什, 疏附县疾病预防控制中心免疫规划股
Wu Xueji	Department of Health Primary, Kashgar Center for Disease Control and Prevention, Kashgar 844100, China
Wang Tongmin	Guangzhou Center for Disease Control and Prevention, Guangzhou, 510440 China Department of Immunization Programme, Kashgar Center for Disease Control and Prevention, Kashgar 844100, China
Li Yaohui	Department of Health Primary, Kashgar Center for Disease Control and Prevention, Kashgar 844100, China
Song Xuelian	844100 喀什, 疏附县疾病预防控制中心免疫规划股
Chao Xianfeng	844100 喀什, 疏附县疾病预防控制中心免疫规划股
Wang Gang	844100 喀什, 疏附县卫生局
Nazibam·Nurmamat	844100 喀什, 疏附县疾病预防控制中心免疫规划股
Ayxamgul·Bawudun	844100 喀什, 疏附县疾病预防控制中心免疫规划股
Gulbahar·Elyas	844100 喀什, 疏附县疾病预防控制中心免疫规划股
Zhou Ziyan	Department of Immunization Programme, Kashgar Center for Disease Control and Prevention, Kashgar 844100, China
Sun Baoshan	Immunization Programme Section, Shufu Center for Disease Control and Prevention, Kashgar 844100, China Department of Disease Control and Prevention, Health and Family Planning Commission of Guangdong Province, Guangzhou 510060, China
Wang Yuzhong	844100 喀什, 疏附县卫生局
Wang Ming	Office of Director, Kashgar Center for Disease Control and Prevention, Kashgar 844100, China	wangming@gzcdc.org.cn

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Abstract:

目的了解新疆喀什地区维吾尔族糖尿病人群血脂异常及控制情况，为防治该地区糖尿病人群血脂紊乱提供依据。方法采用分层整群随机抽样方法，对该地区5 078名18岁及以上的常住居民进行调查问卷、体格检查和实验室检测后，筛查糖尿病患者521例，描述其血脂异常以及各项血脂控制情况，分析造成血脂异常和影响血脂控制的因素。结果糖尿病人群血脂代谢异常总患病率为59.50%（310/521），标化率为49.39%。65岁以上、超重、肥胖和腹部肥胖者发生血脂异常的风险分别增高0.771倍（95% CI：1.015～3.088）、1.132倍（95% CI：1.290～3.523）、1.688倍（95% CI：1.573～4.592）和0.801倍（95% CI：1.028～3.155）。和男性相比，女性是血脂异常的保护性因素，OR=0.507（95% CI：0.334～0.769）。TC、TG、HDL-C和LDL-C的总体控制率为11.13%。女性、BMI超标和腹部肥胖不利于血脂的总体控制。LDL-C的控制率随年龄、BMI和腰围的增大而降低（趋势检验χ²_年龄=18.049，P<0.001；趋势检验χ²_BMI=10.582， P=0.001；χ²_腰围=19.081，P<0.001），随学历增高而增高（趋势检验χ²=9.764，P=0.002）。结论该地区糖尿病人群血脂异常率处于较高水平，血脂总控制率则处于较低水平。肥胖是造成该地区糖尿病人群发生血脂异常的主要危险因素；女性在糖尿病血脂异常的防治中应该得到更多的重视。

English Abstract:

Objective To understand the prevalence of dyslipidemia and normal blood lipids level in Uygur diabetes patients in Kashgar prefecture in southern area of Xinjiang. Methods A total of 5 078 local residents aged ≥ 18 years (42.56% were men) selected through cluster random sampling in Kashgar were surveyed by means of questionnaire survey, physical examination and laboratory test, and 521 diabetes patients were screened. Results The overall prevalence of dyslipidemia in diabetes patients was 59.50% (310/521) with adjusted rate as 49.39%. Age ≥ 65 years, overweight, obesity and abdominal obesity increased the risk for dyslipidemia by 0.771 times (95%CI:1.015-3.088), 1.132 times (95%CI:1.290-3.523), 1.688 times (95%CI:1.573-4.592) and 0.801 times (95%CI:1.028- 3.155) respectively. Compared with males, female was a protective factor for dyslipidemia (OR=0.507, 95%CI:0.334-0.769). The overall normal rate of blood lipids level including total cholesterol (TC), triglycerides (TG), high-density lipoprotein cholesterol (HDL-C) and low-density lipoprotein cholesterol (LDL-C) for type 2 diabetes patients was 11.13%. Female, higher BMI and abdominal obesity were the factors influencing the overall normal blood lipids level. The normal rate of LDL-C level decreased with increase of age, BMI and waist circumferences (trend test χ²=18.049, P<0.001; trend test χ²=10.582, P=0.001; χ²=19.081, P<0.001), but increased with educational level (trend test χ²=9.764, P=0.002). Conclusion The prevalence of dyslipidemia in Uygur diabetes patients in Kashgar was high, however, the overall normal rate of blood lipid level was relatively low. Obesity was the most important risk factor for dyslipidemia in this area. More attention should be paid to dyslipidemia prevention in women.

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