妊娠意愿与孕中晚期妊娠相关焦虑关联的队列研究

尤优; 严双琴; 黄锟; 毛雷婧; 周珊珊; 葛星; 郝加虎; 朱鹏; 陶芳标

Abstract

尤优,严双琴,黄锟,毛雷婧,周珊珊,葛星,郝加虎,朱鹏,陶芳标.妊娠意愿与孕中晚期妊娠相关焦虑关联的队列研究[J].Chinese journal of Epidemiology,2017,38(9):1179-1182

妊娠意愿与孕中晚期妊娠相关焦虑关联的队列研究

Pregnancy intention and pregnancy-related anxiety in the second and third trimester:a birth cohort study

Received:January 17, 2017

DOI：10.3760/cma.j.issn.0254-6450.2017.09.007

KeyWord: 妊娠相关焦虑妊娠意愿队列研究

English Key Word: Pregnancy-related anxiety Pregnancy intention Cohort study

FundProject:国家自然科学基金（81330068，81373012）

Author Name	Affiliation	E-mail
You You	Anhui Provincial Key Laboratory of Population Health and Aristogenics, Department of Maternal and Child Health, Anhui Medical University, Hefei 230032, China
Yan Shuangqin	Maternal and Child Health Care Center of Ma'anshan, Ma'anshan 243000, China
Huang Kun	Anhui Provincial Key Laboratory of Population Health and Aristogenics, Department of Maternal and Child Health, Anhui Medical University, Hefei 230032, China
Mao Leijing	Anhui Provincial Key Laboratory of Population Health and Aristogenics, Department of Maternal and Child Health, Anhui Medical University, Hefei 230032, China
Zhou Shanshan	Anhui Provincial Key Laboratory of Population Health and Aristogenics, Department of Maternal and Child Health, Anhui Medical University, Hefei 230032, China
Ge Xing	Anhui Provincial Key Laboratory of Population Health and Aristogenics, Department of Maternal and Child Health, Anhui Medical University, Hefei 230032, China
Hao Jiahu	Anhui Provincial Key Laboratory of Population Health and Aristogenics, Department of Maternal and Child Health, Anhui Medical University, Hefei 230032, China
Zhu Peng	Anhui Provincial Key Laboratory of Population Health and Aristogenics, Department of Maternal and Child Health, Anhui Medical University, Hefei 230032, China
Tao Fangbiao	Anhui Provincial Key Laboratory of Population Health and Aristogenics, Department of Maternal and Child Health, Anhui Medical University, Hefei 230032, China	fbtao@ahmu.edu.cn

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Abstract:

目的探讨妊娠意愿与孕中、晚期妊娠相关焦虑关联及其强度。方法在马鞍山优生优育队列（MABC）中，将孕周≤ 14周、符合纳入标准的3 474名孕妇纳入队列。在首次产检时收集孕妇的一般人口学信息，并在孕中期和孕晚期收集妊娠相关焦虑量表。采用logistic回归分析妊娠意愿对孕中期和孕晚期妊娠相关焦虑的影响。结果最终3 083人纳入分析，意外妊娠检出率为15.00%（n=461）。孕中期和孕晚期妊娠相关焦虑检出率分别为29.13%（n=898）、30.36%（n=936）。控制潜在的混杂因素后，与有充分思想准备的孕妇相比，意外妊娠的孕妇孕中期出现妊娠相关焦虑的风险增加（OR=1.85，95%CI：1.44~2.38）；孕晚期出现妊娠相关焦虑的风险也增加（OR=1.84，95%CI：1.44~2.35）；顺其自然怀孕的孕妇在孕中、晚期未增加妊娠相关焦虑发生风险。结论意外妊娠是孕中、晚期妊娠相关焦虑危险因素。

English Abstract:

Objective To understand the association between pregnancy intention and pregnancy-related anxiety in the second and third trimester and its strength. Methods A prospective cohort study was conducted in Ma'anshan, Anhui province. A total of 3 474 eligible pregnant women within 14 weeks of gestation were recruited. The information about their demographic characteristics were collected in early pregnancy. The completed questionnaire of pregnancy-related anxiety were asked to return in the second and third trimester. Logistic regression analysis was conducted to evaluate the association between pregnancy intention and pregnancy-related anxiety in the second and third trimester. Results A total of 3 083 pregnant women were included in final analysis, The rate of unintentional pregnancy was 15.00% (n=461). The detection rates of pregnancy-related anxiety in the second and third trimester were 29.13% (n=898) and 30.36% (n=936). After controlling potential confounding factors, unintentional pregnancy increased the risk of pregnancy-related anxiety in the second trimester compared with intentional pregnancy (OR=1.85, 95%CI:1.44-2.38); The risk of pregnancy-related anxiety also increased in the third trimester (OR=1.84, 95%CI:1.44-2.35). Intentional pregnancy did not increase the risk of pregnancy-related anxiety in the second and third trimester. Conclusion The study results suggests that unintentional pregnancy could increase the risk of pregnancy-related anxiety in the second and third trimester.

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