| 范春丽,罗家有,龚雯洁,刘小群,周书进,张芬芳,曾洁,李辉霞,冯娜.妊娠期并发贫血影响因素的巢式病例对照研究[J].Chinese journal of Epidemiology,2017,38(9):1269-1273 |
| 妊娠期并发贫血影响因素的巢式病例对照研究 |
| Nested case-control study on associated factors for anemia during pregnancy |
| Received:January 13, 2017 |
| DOI：10.3760/cma.j.issn.0254-6450.2017.09.025 |
| KeyWord: 妊娠期并发贫血 影响因素 巢式病例对照研究 |
| English Key Word: Anemia during pregnancy Associated factor Nested case-control study |
| FundProject:国家自然科学基金（81172680） |
| Author Name | Affiliation | E-mail | | Fan Chunli | Department of Maternal and Child Health, School of Public Health, Central South University, Changsha 410078, China | | | Luo Jiayou | Department of Maternal and Child Health, School of Public Health, Central South University, Changsha 410078, China | jiayouluo@126.com | | Gong Wenjie | Department of Maternal and Child Health, School of Public Health, Central South University, Changsha 410078, China | | | Liu Xiaoqun | Department of Maternal and Child Health, School of Public Health, Central South University, Changsha 410078, China | | | Zhou Shujin | Liuyang County Women and Children Health Center, Liuyang 410300, China | | | Zhang Fenfang | Liuyang County Women and Children Health Center, Liuyang 410300, China | | | Zeng Jie | Liuyang County Women and Children Health Center, Liuyang 410300, China | | | Li Huixia | Women and Children Health Center of Hunan Province, Changsha 410078, China | | | Feng Na | Women and Children Health Center of Hunan Province, Changsha 410078, China | |
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| Abstract: |
| 目的 探讨妊娠期并发贫血的影响因素。方法 将2013年6月至2014年11月在湖南省浏阳市医疗机构接受首次孕期保健，且经体检排除"贫血"的孕妇（怀孕≤ 12周）纳入孕妇人群队列，对观察对象进行基线调查，并随访至孕妇分娩。采用前瞻性巢式病例对照研究，将本次随访期间新发生贫血的380例孕妇作为病例组，按照1：2频数匹配，随机抽取年龄、孕期、常住地基本相同的760例正常孕产妇作为对照组，采用t检验、χ2检验和条件logistic回归分析方法，分析妊娠期并发贫血的影响因素。结果 多因素logistic回归模型分析结果表明，家庭人均年收入低（OR=2.08，95%CI：1.22~3.59）、文化程度低（OR=2.09，95%CI：1.22~3.59）、孕前烫发/染发（OR=2.23，95%CI：1.63~3.05）、早孕呕吐反应（OR=2.51，95%CI：1.56~4.03）是妊娠期并发贫血的危险因素；摄入维生素、微量元素补充剂（OR=0.69，95%CI：0.50~0.94），肉、鱼、虾、蛋类摄入频率高（OR=0.68，95%CI：0.49~0.92），豆奶、牛奶摄入频率高（OR=0.51，95%CI：0.27~0.95）是妊娠期并发贫血的保护因素。结论 妊娠期并发贫血与孕妇家庭经济、文化程度、有毒有害物质接触、早孕呕吐反应、营养物质的摄入等因素有关，应加强对孕妇妊娠期发生贫血影响因素的控制。 |
| English Abstract: |
| Objective To explore the related factors of anemia during pregnancy and provide scientific evidence for the primary prevention of anemia during pregnancy. Methods The pregnant women (≤ 12 pregnant weeks) who received the first pregnancy care in a local medical institution in Hunan province from June 2013 to November 2014 were included in this cohort study, and for them anemia had been excluded by physical examination. Baseline survey and follow up till childbirth were conducted for them. A queue-based nested case-control study (1:2) was conducted (380 pregnant women with anemia detected in this study as case group, 760 pregnant women without anemia randomly selected and matched by age, habitual residence during pregnancy as control group. And t test, χ2 test and logistic regression analysis were conducted to identify related factors of anemia during pregnancy. Results Multivariate logistic regression analysis indicated that low family annual income level (net income) (OR=2.08, 95%CI:1.22-3.59), low educational level (OR=2.09, 95%CI:1.22-3.59), pre-pregnancy perm/hair dye (OR=2.23, 95%CI:1.63-3.05), early pregnancy vomiting (OR=2.51, 95%CI:1.56-4.03) were the risk factors for anemia during pregnancy. Intake of vitamin and trace element supplements (OR=0.69, 95%CI:0.50-0.94), frequent meat, fish, shrimp, egg intakes (OR=0.68, 95%CI:0.49-0.92), frequent soy milk, milk intakes (OR=0.51, 95%CI:0.27-0.95) were the protective factors for anemia during pregnancy. Conclusion A number of factors, such as family annual income level, education level, poisonous and harmful material contact, pregnancy reaction, nutrition, are related to the incidence of anemia during pregnancy, it is necessary to take preventive measures to reduce the incidence of anemia during pregnancy. |
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