| 热依汗古丽·买买提,刘海燕,韩文晖,罗业飞,胡安群,汪艳,王海丽,熊海燕,郑英杰.妊娠期肝内胆汁淤积症对早产发生率的影响[J].Chinese journal of Epidemiology,2017,38(10):1415-1418 |
| 妊娠期肝内胆汁淤积症对早产发生率的影响 |
| Influence of intrahepatic cholestasis during pregnancy on the incidence of preterm birth |
| Received:March 03, 2017 |
| DOI：10.3760/cma.j.issn.0254-6450.2017.10.024 |
| KeyWord: 妊娠期肝内胆汁淤积症 早产 队列研究 |
| English Key Word: Intrahepatic cholestasis of pregnancy Preterm birth Cohort study |
| FundProject:国家自然科学基金（81373065）；上海市教育委员会科研创新重点项目（14ZZ015）；上海市第四轮公共卫生体系建设三年行动计划重点学科项目（15GWZK0202） |
| Author Name | Affiliation | E-mail | | Reyihanguli Maimaiti | Department of Hygienic Microbiology, School of Public Health, Fudan University, Shanghai 200032, China
Department of Epidemiology, School of Public Health, Fudan University, Shanghai 200032, China | | | Liu Haiyan | Department of Laboratory, Anqing Municipal Hospital, Anqing 246003, China | | | Han Wenhui | Department of Obstetrics and Gynecology, Anqing Municipal Hospital, Anqing 246003 China | | | Luo Yefei | Department of Hygienic Microbiology, School of Public Health, Fudan University, Shanghai 200032, China | | | Hu Anqun | Department of Laboratory, Anqing Municipal Hospital, Anqing 246003, China | | | Wang Yan | Department of Obstetrics and Gynecology, Anqing Municipal Hospital, Anqing 246003 China | | | Wang Haili | Department of Hygienic Microbiology, School of Public Health, Fudan University, Shanghai 200032, China | | | Xiong Haiyan | Department of Hygienic Microbiology, School of Public Health, Fudan University, Shanghai 200032, China | | | Zheng Yingjie | Department of Hygienic Microbiology, School of Public Health, Fudan University, Shanghai 200032, China
Key Laboratory for Public Health Safety, Ministry of Education-School of Public Health, Fudan University, Shanghai 200032, China
Key Laboratory for Health Technology Assessment, National Commission of Health and Family Planning, Fudan University, Shanghai 200032, China
The Innovation Center for Social Risk Governance in Health, Shanghai 200032, China | yjzheng@shmu.edu.cn |
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| Abstract: |
| 目的 探讨妊娠期肝内胆汁淤积症（ICP）对早产发生率的影响。方法 采用前瞻性队列研究，以2014年1月1日至2015年3月31日安庆市立医院所有住院分娩的单胎活产孕妇为研究对象。通过调查问卷和医院电子病历系统，收集孕妇人口学信息等资料，采用单因素和多因素统计方法分析ICP对早产发生率的影响。结果 2 758例孕妇ICP发生率为7.25%，早产发生率为16.28%。ICP增加早产和医源性早产的风险，分别为RR=2.33，95% CI：1.67~3.25和RR=8.46，95% CI：5.45~13.12，但对自发性早产的发生无影响（RR=0.94，95% CI：0.57~1.54）。结论 ICP增加医源性早产的发生风险，与自发性早产的发生无明显相关。 |
| English Abstract: |
| Objective Intrahepatic cholestasis during pregnancy (ICP) and its relation to incidence of preterm birth (PTB) were under study. Methods A prospective cohort study was carried out that including all the hospitalized pregnant women with live singleton births, from January 2014 to March 2015 in Anqing Municipal Hospitals. Informed consent was followed in every pregnant woman with related demographic information collected through questionnaire and hospital electronic medical record system. Both univariate and multi-variate statistical methods were used to analyze the relations between ICP and incidence of PTB. Results A total of 2 758 pregnant women were included in this study. The incidence proportions of ICP and PTB appeared as 7.25% and 16.28% respectively. Results from the logistic regression analysis showed that ICP increased the risk of both overall PTB (RR=2.33, 95% CI:1.67-3.25) and medically indicated PTB (RR=8.46, 95% CI:5.45-13.12), but not the spontaneous PTB (RR=0.94, 95% CI:0.57-1.54). Conclusion ICP seemed to have increased the risk on medically indicated PTB but not the spontaneous PTB. |
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