甲状腺癌相关基因突变和表观遗传学研究进展

郑维晖; 龚巍巍; 陆凤; 俞敏

Abstract

郑维晖,龚巍巍,陆凤,俞敏.甲状腺癌相关基因突变和表观遗传学研究进展[J].Chinese journal of Epidemiology,2017,38(11):1579-1583

甲状腺癌相关基因突变和表观遗传学研究进展

Progress in research of thyroid carcinoma related gene mutation and epigenetics

Received:March 27, 2017

DOI：10.3760/cma.j.issn.0254-6450.2017.11.028

KeyWord: 甲状腺癌基因突变表观遗传学

English Key Word: Thyroid carcinoma Gene mutation Epigenetics

FundProject:国家卫生和计划生育委员会科研基金-浙江省医药卫生重大科技计划（WKJ-ZJ-1506）

Author Name	Affiliation	E-mail
Zheng Weihui	School of Medicine, Ningbo University, Ningbo 315211, China
Gong Weiwei	Zhejiang Provincial Center for Disease Control and Prevention, Hangzhou 310051, China
Lu Feng	Zhejiang Provincial Center for Disease Control and Prevention, Hangzhou 310051, China
Yu Min	Zhejiang Provincial Center for Disease Control and Prevention, Hangzhou 310051, China	myu@cdc.zj.cn

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Abstract:

甲状腺癌的分子发病机制也是一个多基因参与、多个步骤的癌变过程。随着分子生物学诊断技术的不断发展，在甲状腺癌组织中发现多种相关基因突变和表观遗传学现象。了解甲状腺癌的最新基因突变和表观遗传学研究进展，有助于甲状腺癌的早期诊断、防治和靶向药物研发。

English Abstract:

Thyroid cancer is one of the most common endocrine malignant tumors, and its molecular pathogenesis is also a process of multiple genes involved in many steps of carcinogenesis. With the development of molecular biology technology, a variety of related gene mutations and epigenetic phenomena have been found in thyroid cancer tissues. It is helpful to understand the latest progress in the research of the gene mutation and epigenetics of thyroid cancer for its early diagnosis, prevention and the development of targeted drugs.

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