| 冯丹,姚添,程雁鹏,潘明虎,李春霞,王君,冯永亮,石璟,黄洪浪,鲁鸿燕,蓝光华,王素萍,张亚玮.艾滋病病毒感染者合并乙型肝炎病毒感染现状及其相关因素研究[J].Chinese journal of Epidemiology,2017,38(12):1624-1628 |
| 艾滋病病毒感染者合并乙型肝炎病毒感染现状及其相关因素研究 |
| Prevalence and related factors of HIV/HBV coinfection among HIV/AIDS patients |
| Received:May 17, 2017 |
| DOI：10.3760/cma.j.issn.0254-6450.2017.12.008 |
| KeyWord: 艾滋病病毒 乙型肝炎病毒 合并感染 相关因素 |
| English Key Word: HIV HBV Coinfection Related factors |
| FundProject:国家科技重大专项（2012ZX10002001）；山西省回国留学人员科研资助项目（2013056）；传染病预防控制国家重点实验室（2016SKLID311） |
| Author Name | Affiliation | E-mail | | Feng Dan | Department of Epidemiology, School of Public Health, Shanxi Medical University, Taiyuan 030001, China | | | Yao Tian | Department of Epidemiology, School of Public Health, Shanxi Medical University, Taiyuan 030001, China | | | Cheng Yanpeng | Department of Epidemiology, School of Public Health, Shanxi Medical University, Taiyuan 030001, China | | | Pan Minghu | Department of Epidemiology, School of Public Health, Shanxi Medical University, Taiyuan 030001, China | | | Li Chunxia | Department of Epidemiology, School of Public Health, Shanxi Medical University, Taiyuan 030001, China | | | Wang Jun | Department of Epidemiology, School of Public Health, Shanxi Medical University, Taiyuan 030001, China | | | Feng Yongliang | Department of Epidemiology, School of Public Health, Shanxi Medical University, Taiyuan 030001, China | | | Shi Jing | Department of Epidemiology, School of Public Health, Shanxi Medical University, Taiyuan 030001, China | | | Huang Honglang | Ningming County Center for Disease Control and Prevention of Guangxi Zhuang Autonomous Regional, Ningming 532500, China | | | Lu Hongyan | Institute for HIV/AIDS Prevention and Control, Guangxi Zhuang Autonomous Regional Center for Disease Control and Prevention, Nanning 530028, China | | | Lan Guanghua | Institute for HIV/AIDS Prevention and Control, Guangxi Zhuang Autonomous Regional Center for Disease Control and Prevention, Nanning 530028, China | | | Wang Suping | Department of Epidemiology, School of Public Health, Shanxi Medical University, Taiyuan 030001, China | spwang88@163.com | | Zhang Yawei | Department of Epidemiology, School of Public Health, Shanxi Medical University, Taiyuan 030001, China
Division of Environmental Health Sciences, School of Public Health, Yale University, New Haven, Connecticut 06520-1942, USA | yawei.zhang@yale.edu |
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| Abstract: |
| 目的 了解HIV感染者HBV合并感染现状，并探讨该人群合并HBV感染的相关因素。方法 采用横断面研究方法，选取广西壮族自治区CDC及宁明县CDC的艾滋病门诊作为研究现场，招募研究对象纳入标准为年龄≥ 18周岁并确诊为HIV感染者，面对面问卷调查内容包括：一般人口学特征、吸毒史、性行为、乙型肝炎感染史等合并感染可能相关的因素。采集血样检测HBsAg。采用EpiData 3.0和SAS 9.4软件进行统计学分析，运用非条件logistic回归分析HIV/HBV合并感染的相关因素。结果 HIV感染者合并感染HBV检出率为13.85%（113/816）。多因素非条件logistic回归分析结果显示，HIV感染者合并感染HBV的危险因素包括年龄（25~45岁者比≥ 45岁者，OR=1.738，95% CI：1.031~2.931）、HBV感染家族史（有HBV感染家族史者比无HBV感染家族史者，OR=2.898，95% CI：1.678~5.005）；无乙型肝炎疫苗接种史（无乙型肝炎疫苗接种史者比乙型肝炎疫苗接种史者，OR=1.744，95% CI：1.052~2.892）。结论 HIV感染者合并感染HBV检出率较高。25~45岁、有HBV家族史者、无乙型肝炎疫苗接种史者的合并感染风险较高。建议针对HIV感染者加强HBV感染监测，控制合并感染。 |
| English Abstract: |
| Objective To reveal the prevalence and the related factors of hepatitis B (HepB) virus infection among HIV/AIDS patients.Methods We conducted a cross-sectional study in two HIV clinics, affiliated to local Centers of Disease Control and Prevention in Guangxi Zhuang Autonomous Regional. A face-to-face interview, with questionnaire was conducted to collect information on socio-demographic characteristics, drug use, and sexual behavior. Blood samples were used to test HBsAg. χ2 test or Fisher's exact test and unconditional logistic regression models were used to identify the influencing factors.Results The prevalence of HBV and HIV co-infection was 13.85% (113/816).Results from multivariate logistic regression analyses showed that age (25-45), family history of HBV and history of HepB vaccination were independent influencing factors for HBV and HIV coinfection, with OR (95% CI) as 1.738 (1.031-2.931), 2.898 (1.678-5.005) and 1.744 (1.052-2.892), respectively.Conclusion The prevalence of HBV among HIV/AIDS patients was significantly higher than that in general population. HIV/AIDS patients aged between 25 and 45 and with family history of HBV were more likely to be infected with HBV, while HepB vaccination was associated with the reduction of HIV/HBV coinfection. Specific comprehensive prevention and treatment programs on HIV/AIDS patients need to be set up. |
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