| 邵珊珊,黄锟,严双琴,尤优,潘维君,陈星,曹慧,朱鹏,郝加虎,陶芳标.孕中晚期妊娠相关焦虑与幼儿18月龄孤独症样行为的队列研究[J].Chinese journal of Epidemiology,2018,39(6):826-829 |
| 孕中晚期妊娠相关焦虑与幼儿18月龄孤独症样行为的队列研究 |
| Association between pregnancy-related anxiety of pregnant women and autism-like behavior in their offspring at 18 months of age |
| Received:September 28, 2017 |
| DOI：10.3760/cma.j.issn.0254-6450.2018.06.025 |
| KeyWord: 妊娠相关焦虑 孤独症样行为 带养人 队列研究 |
| English Key Word: Pregnancy-related anxiety Autism-like behavior Fosterer Cohort study |
| FundProject:国家重点研发计划（2016YFC1000204-2） |
| Author Name | Affiliation | E-mail | | Shao Shanshan | Department of Maternal, Child and Adolescent Health, School of Public Health, Anhui Medical University, Anhui Provincial Key Laboratory of Population Health and Aristogenics, Heifei 230032, China | | | Huang Kun | Department of Maternal, Child and Adolescent Health, School of Public Health, Anhui Medical University, Anhui Provincial Key Laboratory of Population Health and Aristogenics, Heifei 230032, China | | | Yan Shuangqin | Maternal and Child Health Care Center of Ma'anshan, Ma'anshan 243000, China | | | You You | Department of Maternal, Child and Adolescent Health, School of Public Health, Anhui Medical University, Anhui Provincial Key Laboratory of Population Health and Aristogenics, Heifei 230032, China | | | Pan Weijun | Maternal and Child Health Care Center of Ma'anshan, Ma'anshan 243000, China | | | Chen Xing | Department of Maternal, Child and Adolescent Health, School of Public Health, Anhui Medical University, Anhui Provincial Key Laboratory of Population Health and Aristogenics, Heifei 230032, China | | | Cao Hui | Maternal and Child Health Care Center of Ma'anshan, Ma'anshan 243000, China | | | Zhu Peng | Department of Maternal, Child and Adolescent Health, School of Public Health, Anhui Medical University, Anhui Provincial Key Laboratory of Population Health and Aristogenics, Heifei 230032, China | | | Hao Jiahu | Department of Maternal, Child and Adolescent Health, School of Public Health, Anhui Medical University, Anhui Provincial Key Laboratory of Population Health and Aristogenics, Heifei 230032, China | | | Tao Fangbiao | Department of Maternal, Child and Adolescent Health, School of Public Health, Anhui Medical University, Anhui Provincial Key Laboratory of Population Health and Aristogenics, Heifei 230032, China | fbtao@126.com |
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| Abstract: |
| 目的 探讨孕中晚期妊娠相关焦虑与其子女18月龄时孤独症样行为的关系。方法 应用前瞻性队列研究设计，分别在孕中期、孕晚期采用《妊娠相关焦虑量表》评定孕妇妊娠相关焦虑症状，在儿童18月龄时运用《婴幼儿孤独症筛查表-23》A部分评定幼儿孤独症样行为。使用多项logistic回归法分析孕期妊娠相关焦虑对幼儿孤独症样行为的影响。结果 控制协变量后，与无孤独症样行为组相比，孕中晚期均有妊娠相关焦虑者子女比2个孕期均无妊娠相关焦虑者子女更容易发生较多孤独症样行为（RR=2.43，95%CI：1.21~4.86）。但按主要带养人是否为幼儿母亲进行分层后发现，仅在主要带养人为母亲情况下，孕中晚期均有妊娠相关焦虑组子女18月龄时发生较多孤独症样行为的风险，显著高于孕中晚期均无妊娠相关焦虑组（RR=4.22，95%CI：1.73~10.32），在主要带养人不是母亲情况下并不显著。结论 孕中晚期妊娠相关焦虑与幼儿孤独症样行为的关系并不强劲，受儿童带养人情况的影响。 |
| English Abstract: |
| Objective To investigate the relationship of pregnancy-related anxiety of pregnant women in second/third trimesters and autism-like behaviors in their offspring at 18 months of age.Methods Based on a prospective cohort study design, we evaluated the situation of pregnancy-related anxiety of women during second and third trimesters through a Pregnancy-Related Anxiety Questionnaire. Subjects under study were classified into three groups, 1) those with pregnancy-related anxiety during both trimesters, 2) those with pregnancy-related anxiety at one trimester and 3) those without pregnancy-related anxiety in either trimester. When their children were 18 months, autism-like behaviors (ALB) were evaluated, using the part A of Checklist for Autism in Toddlers-23, and then classified into three groups as non-ALB group, minor ALB group and major ALB group. Multi-nominal logistic Regression was used to analyze the relationship of pregnancy-related anxiety with autism-like behaviors.Results Compared with non-ALB group, children whose mother with pregnancy-related anxiety during both trimesters presented significant higher risk on ALB than children whose mother without pregnancy-related anxiety in these two periods (relative risk, RR=2.43, 95% CI:1.21-4.86, P=0.012), major factors as pregnant women's IQ and gestational diabetes mellitus, premature delivery and education levels of fosterers on these pregnant women were under control. Our results from the stratified analysis showed:when in the subgroup that mother was the main fosterer of the child, there was an significant increase of risk in children whose mothers with pregnancy-related anxiety during both trimesters (RR=4.22, 95% CI:1.73-10.32, P=0.002).Conclusion The association between pregnancy-related anxiety and autism-like behavior was not strong but influenced by the fosterer of the child. |
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