核转录因子κB基因多态性与人群感染丙型肝炎病毒的关联性

樊圆圆; 邵建国; 黄鹏; 田亭; 李军; 韩亚萍; 岳明; 章莉莉

Abstract

樊圆圆,邵建国,黄鹏,田亭,李军,韩亚萍,岳明,章莉莉.核转录因子κB基因多态性与人群感染丙型肝炎病毒的关联性[J].Chinese journal of Epidemiology,2018,39(9):1261-1264

核转录因子κB基因多态性与人群感染丙型肝炎病毒的关联性

Association between nuclear factor kappa-light-chain-enhancer of activated B cells genetic polymorphisms and HCV susceptibility among the Chinese population under high-risk

Received:December 01, 2017

DOI：10.3760/cma.j.issn.0254-6450.2018.09.022

KeyWord: 丙型肝炎病毒易感性危险因素核转录因子κB基因

English Key Word: Hepatitis C virus Susceptibility Risk factor Nuclear factor kappa-light-chain-enhancer of activated B cells

FundProject:国家自然科学基金（81502853，81773499，81703273，81473029）；江苏省自然科学基金（BK20151026，BK20171054）；江苏省卫计委“科教强卫工程”青年医学人才项目（QNRC2016616）；江苏省卫计委医学创新团队项目（CXTDA2017023）

Author Name	Affiliation	E-mail
Fan Yuanyuan	Department of Infectious Diseases, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China
Shao Jianguo	Department of Digestive Medicine, The Third People's Hospital of Nantong City, Nantong 226000, China
Huang Peng	Key Laboratory of Infectious Diseases, Department of Epidemiology, School of Public Health, Nanjing Medical University, Nanjing 211166, China
Tian Ting	Key Laboratory of Infectious Diseases, Department of Epidemiology, School of Public Health, Nanjing Medical University, Nanjing 211166, China
Li Jun	Department of Infectious Diseases, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China
Han Yaping	Department of Infectious Diseases, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China
Yue Ming	Department of Infectious Diseases, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China	njym08@163.com
Zhang Lili	Department of Infectious Diseases, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China	dr.zhanglili@gmail.com

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Abstract:

目的探索核转录因子κB（NF-κB）基因多态性与人群感染HCV的关联性。方法本研究共纳入1 679位研究对象（503位吸毒者和1 176位高危血源性暴露者）。通过logistic回归分析人群感染HCV的相关因素，通过TaqMan-MGB探针法对NF-κB1基因rs72696119和REL基因rs13031237位点进行基因分型，并分析其与HCV易感性的相关性。结果在吸毒人群中，女性吸毒者（OR=0.408，95% CI：0.308～0.767）HCV易感性更低，而静脉注射吸毒（OR=8.817，95% CI：5.577～13.937）以及吸毒时间>5.5年（OR=2.891，95% CI：1.824～4.583）则是感染HCV的危险因素。在高危血源暴露人群中，小学以上文化程度（OR=0.613，95% CI：0.429～0.876）是该高危人群感染HCV的保护因素，而女性（OR=3.431，95% CI：2.360～4.988）则是感染HCV的危险因素。在总人群中，携带NF-κB1 rs72696119 GG基因型的个体更易感染HCV（OR=1.412，95% CI：1.035～1.927）。总人群中的交互作用分析显示，rs72696119与HCV感染途径、性别均不存在交互作用（P>0.05）。结论在高危人群中，相关的行为因素和NF-κB1基因rs72696119多态性与HCV易感性相关。

English Abstract:

Objective To explore the association between nuclear factor kappa-light-chain-enhancer of activated genetic polymorphisms in B cells (NF-κB) and the HCV susceptibility, among the Chinese population. Methods A total of 1 679 participants were enrolled; including 503 drug users and 1 176 other participants at risk under the exposure for blood. By using the logistic regression analysis, related risk factors for HCV infection among subjects were analyzed. Two NF-κB pathway variants, NF-κB1 rs72696119 and REL rs13031237 were then genotyped by TaqMan assay method. Logistic regression analysis was performed to analyze the association between gene polymorphisms and the susceptibility on HCV. Results Among the drug users, women (OR=0.408, 95% CI:0.308-0.767) appeared to be associated with the decreased risk for HCV infection, while factors as drug injection (OR=8.817, 95% CI:5.577-13.937) and the duration of drug-intake >5.5 years (OR=2.891, 95% CI:1.824-4.583) were associated with the increased risk for HCV infection. Among the participants who had been exposed to blood, women (OR=3.431, 95% CI:2.360-4.988) were associated with the increased risk for HCV infection, while the levels of education beyond elementary school (OR=0.613, 95% CI:0.429-0.876) were associated with the decreased risk for HCV infection. Compared to the reference NF-κB1 rs72696119 CC genotype, the carriage of GG genotype was associated with an increased risk of susceptibility on HCV (OR=1.412, 95% CI:1.035-1.927) among the total study population. Results from the interaction analysis showed that there was no interactive effects appeared between rs72696119 and route of infection, or between rs72696119 and gender among the total population under study (all P>0.05). Conclusion NF-κB1 polymorphism rs72696119 and related factors seemed associated with the susceptibility to HCV infection among high-risk Chinese populations.

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