| 李东,陈致飞,杨秀惠,潘伟毅,王琴,张苏晗,郑凝旋,黄丽芳,周勇.福建省2005-2017年流行性腮腺炎疫情及病原学监测分析[J].Chinese journal of Epidemiology,2018,39(10):1356-1361 |
| 福建省2005-2017年流行性腮腺炎疫情及病原学监测分析 |
| Epidemiological and pathogenic characteristics of mumps in Fujian province, 2005-2017 |
| Received:March 12, 2018 |
| DOI：10.3760/cma.j.issn.0254-6450.2018.10.013 |
| KeyWord: 流行性腮腺炎 流行病学特征 病原学特征 |
| English Key Word: Mumps Epidemiological characteristic Pathogenic characteristic |
| FundProject:福建省卫生计生青年科研课题（2017-1-27） |
| Author Name | Affiliation | E-mail | | Li Dong | Fujian Provincial Key Laboratory of Zoonosis Research, Fujian Provincial Center for Disease Control and Prevention, Fuzhou 350001, China | lidongbox2006@163.com | | Chen Zhifei | Fujian Provincial Key Laboratory of Zoonosis Research, Fujian Provincial Center for Disease Control and Prevention, Fuzhou 350001, China | | | Yang Xiuhui | Fujian Provincial Key Laboratory of Zoonosis Research, Fujian Provincial Center for Disease Control and Prevention, Fuzhou 350001, China | | | Pan Weiyi | Fujian Provincial Key Laboratory of Zoonosis Research, Fujian Provincial Center for Disease Control and Prevention, Fuzhou 350001, China | | | Wang Qin | Fujian Provincial Key Laboratory of Zoonosis Research, Fujian Provincial Center for Disease Control and Prevention, Fuzhou 350001, China | | | Zhang Suhan | Fujian Provincial Key Laboratory of Zoonosis Research, Fujian Provincial Center for Disease Control and Prevention, Fuzhou 350001, China | | | Zheng Ningxuan | Fujian Provincial Key Laboratory of Zoonosis Research, Fujian Provincial Center for Disease Control and Prevention, Fuzhou 350001, China | | | Huang Lifang | Fujian Provincial Key Laboratory of Zoonosis Research, Fujian Provincial Center for Disease Control and Prevention, Fuzhou 350001, China | | | Zhou Yong | Fujian Provincial Key Laboratory of Zoonosis Research, Fujian Provincial Center for Disease Control and Prevention, Fuzhou 350001, China | |
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| Abstract: |
| 目的 分析福建省2005-2017年流行性腮腺炎（腮腺炎）的流行病学及病原学特征。方法 通过中国疾病预防控制传染病报告信息管理系统，收集2005-2017年福建省腮腺炎报告病例，主动搜索、访谈收集腮腺炎疫苗接种信息，对新发病例采集咽拭子标本进行腮腺炎病毒（mumps virus，MuV）细胞培养、基因定型及基因序列分析。结果 2005-2017年福建省累计报告腮腺炎病例83 959例，年平均发病率为17.6/10万，2007年后发病率总体呈先上升后下降趋势，到2017年为监测以来的历史新低（7.5/10万）；发病时间呈明显的季节性双峰特征，但第1个发病高峰（4-7月）有减弱趋势，而第2个发病高峰（10月至次年1月）有增强趋势；发病人群以学生、托幼儿童、散居儿童为主（占总病例数89.2%，5 814/6 517），其中5~9岁年龄组年平均发病数达2 527例（占总病例数38.8%）；发病无明显的地域性特征。病原学监测表明福建省存在MuV G基因型病毒株的流行。序列分析发现2015年MuV G基因型病毒株在核苷酸上的突变导致了SH基因编码区6个氨基酸位点变异，进一步加大了与A型疫苗株在核苷酸及氨基酸上的同源性差异。结论 2005-2017年福建省腮腺炎发病逐年下降，预防工作需重点关注中小学生，MuV G基因型病毒株在福建省存在传播链，且在SH基因编码区发现部分氨基酸变异。需加强福建省腮腺炎流行病学及病原学监测工作。 |
| English Abstract: |
| Objective To understand the epidemiological and etiological characteristics of mumps in Fujian province, 2005-2017. Methods All the reported mumps cases were collected through the National Notifiable Disease Information Management System, 2005-2017. Active search and interviews were conducted to collect the information on vaccination of mumps. Throat swab specimens were collected for cells culture, genotyping and gene sequence analysis on mumps virus (MuV). Results A total of 83 959 cases of mumps were reported in Fujian province from 2005 to 2017, with an average annual incidence of 17.6 per 100 000. Since 2007, the incidence appeared increasing but then decreasing, reaching the lowest level (7.5 per 100 000), after the setup of a monitoring program. Annually, the onset time of mumps showed an obvious two seasonal peaks, one from April to July, with a weakening trend, and the other from October to January with a rising trend.Most of the mumps cases occurred among students, kindergarten and scattered children (89.2%, 5 814/6 517), children aged 5-9 years (38.8%, 2 527/6 517), with cases reported from every region. Program from the pathogen surveillance showed that the transmission chain of G genotype mumps virus did exist in Fujian. Data from the sequence analysis revealed that mutations in the nucleotide of G genotype strain in 2015 had led to mutation of 6 amino acid sites in the SH gene coding region, resulting in the differences appearing in both nucleotide and amino acid homology with type A vaccine strain. Conclusions The incidence of mumps decreased annually, in Fujian. Prevention programs should focus on primary and secondary school students. In Fujian province, we also noticed the transmission chain of mumps G genotype with some amino acid mutations in the SH gene coding region. Monitor programs on both epidemiologic and etiology, should be strengthened. |
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