| 薛秀娟,闫江舟,程栋,刘春华,刘佳,刘铮,田随安,孙定勇,张伯伟,王哲.河南省2011-2016年HIV感染长期不进展者人类白细胞抗原基因多态性分析[J].Chinese journal of Epidemiology,2019,40(1):89-92 |
| 河南省2011-2016年HIV感染长期不进展者人类白细胞抗原基因多态性分析 |
| Human leukocyte antigen polymorphism of HIV infected persons without disease progress for long-term in Henan province, 2011-2016 |
| Received:July 19, 2018 |
| DOI：10.3760/cma.j.issn.0254-6450.2019.01.018 |
| KeyWord: 艾滋病病毒 长期不进展者 人类白细胞抗原 基因多态性 |
| English Key Word: HIV Long-term non-progressor Human leukocyte antigen Genetic polymorphism |
| FundProject:河南省基础与前沿技术研究课题（162300410123）；河南省医学科技攻关计划（201602311）；国家科技重大专项（2018ZX10715009-003-002，2017ZX10201101-001-010） |
| Author Name | Affiliation | E-mail | | Xue Xiujuan | Department of AIDS/STD Control and Prevention, Henan Provincial Center for Disease Control and Prevention, Zhengzhou 450016, China | | | Yan Jiangzhou | Department of AIDS/STD Control and Prevention, Henan Provincial Center for Disease Control and Prevention, Zhengzhou 450016, China | | | Cheng Dong | Xinxiang Prefecture Center for Disease Control and Prevention, Xinxiang 453000, China | | | Liu Chunhua | Department of AIDS/STD Control and Prevention, Henan Provincial Center for Disease Control and Prevention, Zhengzhou 450016, China | | | Liu Jia | Department of AIDS/STD Control and Prevention, Henan Provincial Center for Disease Control and Prevention, Zhengzhou 450016, China | | | Liu Zheng | Henan Red Cross Blood Center, Zhengzhou 450016, China | | | Tian Sui'an | Department of AIDS/STD Control and Prevention, Henan Provincial Center for Disease Control and Prevention, Zhengzhou 450016, China | | | Sun Dingyong | Department of AIDS/STD Control and Prevention, Henan Provincial Center for Disease Control and Prevention, Zhengzhou 450016, China | | | Zhang Bowei | Henan Red Cross Blood Center, Zhengzhou 450016, China | | | Wang Zhe | Department of AIDS/STD Control and Prevention, Henan Provincial Center for Disease Control and Prevention, Zhengzhou 450016, China | wangzhe@hncdc.com.cn |
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| Abstract: |
| 目的 分析河南省HIV感染长期不进展者（LTNP）病程进展及人类白细胞抗原（HLA）基因多态性特征。方法 采用回顾性研究，对河南省2011-2016年检测及随访信息完整的48例LTNP进行分析，探讨随访期间CD4+T淋巴细胞计数（CD4）、病毒载量（VL）的变化情况。采用聚合酶链式反应-序列特异性寡核苷酸探针技术（PCR-SSOP）对LTNP及健康对照的HLA-A、HLA-B和HLA-DRB1基因位点多态性进行分析。结果 2011-2016年48例LTNP 6次随访检测发现，CD4的四分位数从601.00（488.50~708.72）个/μl降低至494.00（367.00~672.00）个/μl，差异有统计学意义（P<0.05）。log10VL的四分位数从3.40（2.87~3.97）上升到3.48（2.60~4.37），差异无统计学意义（P>0.05）。HLA基因位点多态性分析显示，HLA-B*13：02、HLA-B*40：06位点多分布在LTNP中（P<0.05），而HLA-B*46：01、HLA-DRB1*09：01在健康对照中常见（P<0.05）。结论 河南省LTNP CD4有逐年下降的趋势，HLA-B*13：02、HLA-B*40：06等位基因位点可能与延缓本地区LTNP疾病进程有关。 |
| English Abstract: |
| Objective To understand the disease progression and human leukocyte antigen (HLA) gene polymorphism of HIV-infected persons without disease progress for long term, also known as long-term non-progressors (LTNPs), in Henan province. Methods A retrospective study was conducted in 48 LTNPs with complete detection and follow-up information during 2011-2016 in Henan. Changes of CD4+T cells counts (CD4) and viral load (VL) during follow-up period were discussed. Polymerase chain reaction-sequence-specific oligonucleotide probe (PCR-SSOP) was used for the analyses of HLA-A, HLA-B and HLA-DRB1 alleles between LTNPs and healthy controls. Results From 2011 to 2016, forty-eight LTNPs showed a decrease of the quartile (P25-P75) of CD4 from 601.00 (488.50-708.72)/μl to 494.00 (367.00-672.00)/μl, and the difference was significant (P<0.05). The increase of the quartile (P25-P75) of log10VL from 3.40 (2.87-3.97) to 3.48 (2.60-4.37), but the difference was not significant (P>0.05). HLA polymorphism analysis revealed that HLA-B*13:02 and HLA-B*40:06 were more common in LTNPs (P<0.05), while HLA-B*46:01 and HLA-DRB1*09:01 were more common in healthy controls (P<0.05). Conclusions The CD4 of LTNPs in Henan showed a downward trend year by year. HLA-B*13:02 and B*40:06 might be associated with delayed disease progression for HIV infected persons in Henan. |
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