| 刘俭,马学华,闫乐媛,刘淼,王盛书,何耀.某科研人群血脂异常与颈动脉斑块发病关系的前瞻性队列研究[J].Chinese journal of Epidemiology,2019,40(3):341-345 |
| 某科研人群血脂异常与颈动脉斑块发病关系的前瞻性队列研究 |
| Association between dyslipidemia and carotid plaque incidence in a research group: a prospective cohort study |
| Received:September 08, 2018 |
| DOI：10.3760/cma.j.issn.0254-6450.2019.03.016 |
| KeyWord: 血脂异常 颈动脉斑块 队列研究 前瞻性研究 |
| English Key Word: Dyslipidemia Carotid plaque Cohort study Prospective study |
| FundProject:北京市科委课题（Z161100005016021）；国家自然科学基金（81703285，81773502）；北京市自然科学基金（7174350）；北京市科技新星（Z181100006218085）；国家老年疾病临床医学研究中心开放课题（NCRCG-PLAGH-2017017） |
| Author Name | Affiliation | E-mail | | Liu Jian | Physical Examination Center, The Fourth Medical Center of People's Liberation Army General Hospital, Beijing 100037, China | | | Ma Xuehua | Physical Examination Center, The Fourth Medical Center of People's Liberation Army General Hospital, Beijing 100037, China | | | Yan Leyuan | Physical Examination Center, The Fourth Medical Center of People's Liberation Army General Hospital, Beijing 100037, China | | | Liu Miao | Institute of Geriatrics, Chinese People's Liberation Army General Hospital, Beijing 100853, China
Beijing Key Laboratory of Research on Aging and Related Diseases, Chinese People's Liberation Army General Hospital, Beijing 100853, China
State Key Laboratory of Kidney Disease, Chinese People's Liberation Army General Hospital, Beijing 100853, China
National Clinical Research Center for Geriatrics Diseases, Chinese People's Liberation Army General Hospital, Beijing 100853, China | | | Wang Shengshu | Institute of Geriatrics, Chinese People's Liberation Army General Hospital, Beijing 100853, China
Beijing Key Laboratory of Research on Aging and Related Diseases, Chinese People's Liberation Army General Hospital, Beijing 100853, China
State Key Laboratory of Kidney Disease, Chinese People's Liberation Army General Hospital, Beijing 100853, China
National Clinical Research Center for Geriatrics Diseases, Chinese People's Liberation Army General Hospital, Beijing 100853, China | | | He Yao | Institute of Geriatrics, Chinese People's Liberation Army General Hospital, Beijing 100853, China
Beijing Key Laboratory of Research on Aging and Related Diseases, Chinese People's Liberation Army General Hospital, Beijing 100853, China
State Key Laboratory of Kidney Disease, Chinese People's Liberation Army General Hospital, Beijing 100853, China
National Clinical Research Center for Geriatrics Diseases, Chinese People's Liberation Army General Hospital, Beijing 100853, China | yhe301@sina.com |
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| Abstract: |
| 目的 探讨基线血脂异常与颈动脉斑块发病风险的关联及其强度。方法 本研究为前瞻性队列研究。2017年对参加2010年基线调查的解放军第三○四医院健康体检的716名科研工作者开展随访调查，随访结局为颈动脉斑块发生。结果 基线716名非颈动脉斑块人群经8年随访，共发生颈动脉斑块289例，累计发病率为40.36%。拟合Cox比例风险模型，在调整了年龄、性别、BMI、腰围、SBP、DBP、ALT、FPG和尿酸后，以无血脂异常组为对照组，该职业人群患有≥ 3种血脂异常组发生颈动脉斑块风险升高68.1%（HR=1.681，95% CI：1.090~2.593）。结论 血脂异常与颈动脉斑块发生相关，有≥ 3种血脂异常人群的颈动脉斑块发病风险升高，防止血脂异常或减少血脂异常的种类可能是预防和控制颈动脉斑块形成的有效措施之一。 |
| English Abstract: |
| Objective To assess the association and intensity of baseline dyslipidemia with the incidence of carotid plaque in a researchers group in China. Methods A total of 716 researchers were enrolled in this prospective cohort study. Dyslipidemia was assessed in 2010. Follow-up study on carotid plaque was conducted in 2017. Results Over 8 years' follow-up, 289 carotid plaque patients were identified among 716 individuals who did not have carotid plaque at baseline survey, with cumulative incidence of 40.36%. After adjustment of age, gender, BMI, waist circumference, FPG, SBP, DBP, ALT and uric acid, compared with non-dyslipidemia group, HR of carotid plaque for such populations with ≥ 3 types of dyslipidemia was 1.681 (95% CI:1.090——2.593). Conclusions Dyslipidemia might be associated with higher risk of carotid plaque, and population with ≥ 3 types of dyslipidemia had higher risk for carotid plaque. Prevention of dyslipidemia or reduction of types of dyslipidemia might be one of the effective precautions for prevention of carotid plaque. |
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