| 甘凤夏,高文静,吕筠,余灿清,王胜锋,逄增昌,丛黎明,董忠,吴凡,汪华,吴先萍,江国虹,王晓节,王滨有,畅征,Ralf Kuja-Halkola,曹卫华,李立明.中国成年双生子人群的糖尿病遗传度研究[J].Chinese journal of Epidemiology,2019,40(4):389-393 |
| 中国成年双生子人群的糖尿病遗传度研究 |
| Analysis on the heritability of diabetes, based on data from the Chinese adult twins |
| Received:September 14, 2018 |
| DOI：10.3760/cma.j.issn.0254-6450.2019.04.004 |
| KeyWord: 糖尿病 双生子研究 遗传度 |
| English Key Word: Diabetes mellitus Twin study Heritability |
| FundProject:公益性行业科研专项（201502006，201002007）；国家自然科学基金（81711530051） |
| Author Name | Affiliation | E-mail | | Gan Fengxia | Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing 100191, China | | | Gao Wenjing | Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing 100191, China | | | Lyu Jun | Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing 100191, China | | | Yu Canqing | Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing 100191, China | | | Wang Shengfeng | Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing 100191, China | | | Pang Zengchang | Qingdao Center for Disease Control and Prevention, Qingdao 266033, China | | | Cong Liming | Zhejiang Center for Disease Control and Prevention, Hangzhou 310051, China | | | Dong Zhong | Beijing Center for Disease Control and Prevention, Beijing 100013, China | | | Wu Fan | Shanghai Center for Disease Control and Prevention, Shanghai 200336, China | | | Wang Hua | Jiangsu Center for Disease Control and Prevention, Nanjing 210008, China | | | Wu Xianping | Sichuan Center for Disease Control and Prevention, Chengdu 610041, China | | | Jiang Guohong | Tianjin Center for Disease Control and Prevention, Tianjin 300011, China | | | Wang Xiaojie | Qinghai Center for Disease Control and Prevention, Xining 810007, China | | | Wang Binyou | Harbin Medical University, Harbin 150001, China | | | Chang Zheng | Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm 17177, Sweden | | | Ralf Kuja-Halkola | Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm 17177, Sweden | | | Cao Weihua | Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing 100191, China | caoweihua60@163.com | | Li Liming | Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing 100191, China | |
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| Abstract: |
| 目的 分析中国成年双生子人群的糖尿病遗传度。方法 利用中国双生子登记系统9省市的10 253对同性别双生子进行面访式问卷调查的相关信息，通过结构方程模型计算糖尿病的遗传度。结果 调整年龄和性别后，糖尿病的遗传度为0.41（0.15~0.75）；进一步亚组分析显示，<45和≥ 45岁组的遗传度分别为0.83（0.72~0.91）和0.34（0.04~0.73），男、女性的遗传度分别为0.37（0.05~0.78）和0.88（0.79~0.94）。结论 糖尿病受遗传和环境因素的共同影响，女性双生子糖尿病的遗传效应高于男性，年龄越大，遗传效应越小。 |
| English Abstract: |
| Objective To analyze the heritability of diabetes among the Chinese twin adults. Methods A total of 10 253 same-sex twin pairs aged 25 years and older, were selected from the Chinese National Twin Registry (CNTR) program. Heritability of diabetes was calculated by using the structural equation model. Results After adjusted for age and gender, the overall heritability rates of diabetes were 0.41 (0.15-0.75), 0.83 (0.72-0.91) and 0.34 (0.04-0.73) in the <45 and ≥ 45 years twin pairs, respectively. After adjusted for age, rates of heritability appeared as 0.37 (0.05-0.78) and 0.88 (0.79-0.94) in men and women, respectively. Conclusions Diabetes is affected by both genetic and environmental factors. The genetic effect of diabetes seemed stronger on female than that on male twins but was dying down along with ageing. |
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