| 卓凌云,黄鹏,凡豪志,巫晶晶,王炎,叶翔宇,喻荣彬.江苏省某戒毒所男性吸毒人员甲状腺激素水平及影响因素研究[J].Chinese journal of Epidemiology,2019,40(9):1134-1138 |
| 江苏省某戒毒所男性吸毒人员甲状腺激素水平及影响因素研究 |
| Study on thyroid hormone levels and influence factors in drug users in a drug rehabilitation center in Jiangsu province |
| Received:January 21, 2019 |
| DOI：10.3760/cma.j.issn.0254-6450.2019.09.022 |
| KeyWord: 吸毒 甲状腺 丙型肝炎病毒 三碘甲状腺原氨酸 |
| English Key Word: Drug use Thyroid Hepatitis C virus Triiodothyronine |
| FundProject:国家自然科学基金（81473029，81703273）；江苏省自然科学基金（BK20171054） |
| Author Name | Affiliation | E-mail | | Zhuo Lingyun | School of Public Health, Nanjing Medical University, Nanjing 211166, China | | | Huang Peng | School of Public Health, Nanjing Medical University, Nanjing 211166, China | | | Fan Haozhi | School of Public Health, Nanjing Medical University, Nanjing 211166, China | | | Wu Jingjing | School of Public Health, Nanjing Medical University, Nanjing 211166, China | | | Wang Yan | School of Public Health, Nanjing Medical University, Nanjing 211166, China | | | Ye Xiangyu | School of Public Health, Nanjing Medical University, Nanjing 211166, China | | | Yu Rongbin | School of Public Health, Nanjing Medical University, Nanjing 211166, China | rongbinyu@njmu.edu.cn |
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| Abstract: |
| 目的 了解吸毒人群促甲状腺激素（TSH）、三碘甲状腺原氨酸（T3）、甲状腺素（T4）、游离三碘甲状腺原氨酸（FT3）以及游离甲状腺素（FT4）的异常情况及影响因素。方法 2018年6－8月于江苏省某戒毒所招募788名男性吸毒人员进行一对一的问卷调查并采集静脉血进行甲状腺功能5项激素项目的检测。结果 调查结果显示，江苏省某戒毒所男性戒毒人员的血清T3、T4、FT3、FT4以及TSH的异常率分别为4.57%、1.27%、0.51%、0.38%和0.89%。HCV感染是该人群发生T3异常的影响因素（OR=8.52，95% CI：2.36～30.74，P=0.001），且血清T3（P<0.001）和T4（P=0.048）水平随着HCV病毒载量的升高而升高。结论 HCV感染是男性吸毒人员发生血清T3水平异常的影响因素。因此，在对吸毒人群进行健康教育时应增加甲状腺相关的知识，对感染HCV的男性吸毒人员还应加强甲状腺功能的监测。 |
| English Abstract: |
| Objective To understand the serum levels of thyroid stimulating hormone (TSH), free triiodothyronine (FT3), free thyroxine (FT4), triiodothyronine (T3), and thyroxine (T4) and identify the related influencing factors of thyroid dysfunction in drug users. Methods From June to August 2018, a face-to-face questionnaire survey was conducted in 788 male drug users in a drug rehabilitation center in Jiangsu province to collect their socio-demographic information. Then, venous blood sample was collected from each participant for the detection of various hematological indicators, such as thyroid hormones. Results The abnormal rates of T3, T4, FT3, FT4 and TSH were 4.57%, 1.27%, 0.51%, 0.38% and 0.89%, respectively, in the male drug users. HCV infection was an influencing factor for abnormal T3 level in the male drug users (OR=8.52, 95%CI:2.36-30.74, P=0.001). And serum T3 (P<0.001) and T4 (P=0.048) levels increased with increasing HCV viral load. Conclusions HCV infection was an influencing factor for the abnormality of serum T3 level in drug users. Therefore, thyroid-related knowledge should be added in the health education for drug users, and the monitoring of thyroid function should be strengthened for drug users infected with HCV. |
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