50岁及以上人群手握力与空气污染的关联研究

郭雁飞; 阮晔; 林华亮; 马文军; 张庆军; 孙双圆; 黄哲宙; 郑杨; 施燕; 吴凡

Abstract

郭雁飞,阮晔,林华亮,马文军,张庆军,孙双圆,黄哲宙,郑杨,施燕,吴凡.50岁及以上人群手握力与空气污染的关联研究[J].Chinese journal of Epidemiology,2019,40(10):1240-1244

50岁及以上人群手握力与空气污染的关联研究

Association between low handgrip strength and air pollution among people aged 50 years and over

Received:January 30, 2019

DOI：10.3760/cma.j.issn.0254-6450.2019.10.013

KeyWord: 空气污染手握力

English Key Word: Air pollution Handgrip strength

FundProject:美国国立老化研究所资助项目（R01-AG034479）；上海市卫生和计划生育委员会科研项目（201640148，201840118，20174Y0147）

Author Name	Affiliation	E-mail
Guo Yanfei	Shanghai Municipal Center for Disease Control and Prevention, Shanghai 200336, China
Ruan Ye	Shanghai Municipal Center for Disease Control and Prevention, Shanghai 200336, China
Lin Hualiang	Department of Epidemiology, School of Public Health, Sun Yat-sen University, Guangzhou 510080, China
Ma Wenjun	Guangdong Provincial Institute of Public Health, Guangzhou 511430, China
Zhang Qingjun	Hubei Provincial Center for Disease Control and Prevention, Wuhan 430079, China
Sun Shuangyuan	Shanghai Municipal Center for Disease Control and Prevention, Shanghai 200336, China
Huang Zhezhou	Shanghai Municipal Center for Disease Control and Prevention, Shanghai 200336, China
Zheng Yang	Shanghai Municipal Center for Disease Control and Prevention, Shanghai 200336, China
Shi Yan	Shanghai Municipal Center for Disease Control and Prevention, Shanghai 200336, China
Wu Fan	Shanghai Municipal Center for Disease Control and Prevention, Shanghai 200336, China Shanghai Medical College, Fudan University, Shanghai 200032, China	wufan@shmu.edu.cn

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Abstract:

目的分析室内、外空气污染与≥50岁人群手握力的关联。方法采用WHO全球老龄化与成人健康研究中国项目第一轮基线调查，室外空气污染以PM_2.5平均浓度（基于卫星遥感数据进行估计）进行描述，室内空气污染通过燃料和烟囱使用情况进行描述，采用两水平（个体层面和社区层面）线性模型分析室内、外空气污染与中国≥50岁人群手握力的关系。结果共纳入13 175名≥50岁中老年人。手握力为（26.67±0.54）kg。调整性别、年龄、居住地区、文化程度、家庭经济水平、水果蔬菜摄入状况、吸烟、饮酒和体力活动后，室外PM_2.5浓度与手握力呈负相关（β=-0.23，95% CI：-0.31～-0.14）。在农村，相比使用固体燃料（非清洁），使用清洁燃料可以提高手握力值（β=1.41，95% CI：0.36～2.46）。但在城市地区，未发现使用清洁燃料对手握力值有显著影响（β=0.19，95% CI：-0.95～1.32）。结论室外PM_2.5与室内污染合并暴露与≥50岁人群低手握力显著相关，提示了慢性长期空气污染暴露有可能是我国中老年人较低机体功能的重要危险因素之一。

English Abstract:

Objective To examine the association between long-term exposure to ambient PM_2.5 combined with indoor air pollution and handgrip strength among people aged 50 and over. Methods Data were from the first wave of World Health Organization Study on global AGEing and adult health in China. Ambient annual concentration of PM_2.5 was estimated by using the satellite data we also investigated the use of fuels and chimneys as indoor air pollution. A two-level (individual level and community level) linear model was applied to examine the association between long-term exposure to ambient PM_2.5 combined with indoor air pollution and the handgrip strength. Results A total of 13 175 individuals aged 50 years and over were included for analysis. The handgrip strength was (26.67±0.54) kg. Ambient PM_2.5 was found to be significantly associated with the risk of decreased handgrip strength. Outdoor PM_2.5 concentration was negatively correlated with handgrip strength (β=-0.23, 95%CI:-0.31—-0.14) decrease in handgrip strength after adjusting for gender, age, residence, education, household assets, intake of vegetables and fruits, smoking and drinking, physical activity. In rural area, compared to those who used solid fuel, use of clean fuel increased (β=1.41, 95%CI:0.36-2.46) handgrip strength. But in urban area, we did not find any statistically significant association between the use of clean fuel and handgrip strength (β=0.19, 95%CI:-0.95-1.32). Conclusion This study found that long-term exposure to ambient PM_2.5 combined with indoor air pollution was significantly associated with low handgrip strength among people aged 50 years and over, this suggested that ambient PM_2.5 might serve as one of the risk factors for low physical function seen in the people aged 50 years and over.

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