陈清,赵峰,黄清湄,吕跃斌,钟文芳,周锦辉,李志浩,曲英莉,刘玲,刘迎春,王蛟男,曹兆进,吴娴波,施小明,毛琛.中国8个长寿地区65岁及以上老年人肾小球滤过率对全因死亡风险的影响[J].Chinese journal of Epidemiology,2020,41(1):36-41 |
中国8个长寿地区65岁及以上老年人肾小球滤过率对全因死亡风险的影响 |
Effects of estimated glomerular filtration rate on all-cause mortality in the elderly aged 65 years and older in 8 longevity areas in China |
Received:June 13, 2019 |
DOI:10.3760/cma.j.issn.0254-6450.2020.01.008 |
KeyWord: 肾小球滤过率 全因死亡 老年人 |
English Key Word: Glomerular filtration rate All-cause mortality Elderly |
FundProject:国家自然科学基金(81973109,81872707,81573247);国家重点研发计划(2018YFC2000400) |
Author Name | Affiliation | E-mail | Chen Qing | Department of Epidemiology, School of Public Health, Southern Medical University, Guangzhou 510515, China | | Zhao Feng | National Institute of Environmental Health, Chinese Center for Disease Control and Prevention, Beijing 100021, China | | Huang Qingmei | Department of Epidemiology, School of Public Health, Southern Medical University, Guangzhou 510515, China | | Lyu Yuebin | National Institute of Environmental Health, Chinese Center for Disease Control and Prevention, Beijing 100021, China | | Zhong Wenfang | Department of Epidemiology, School of Public Health, Southern Medical University, Guangzhou 510515, China | | Zhou Jinhui | National Institute of Environmental Health, Chinese Center for Disease Control and Prevention, Beijing 100021, China | | Li Zhihao | Department of Epidemiology, School of Public Health, Southern Medical University, Guangzhou 510515, China | | Qu Yingli | National Institute of Environmental Health, Chinese Center for Disease Control and Prevention, Beijing 100021, China | | Liu Ling | National Institute of Environmental Health, Chinese Center for Disease Control and Prevention, Beijing 100021, China | | Liu Yingchun | National Institute of Environmental Health, Chinese Center for Disease Control and Prevention, Beijing 100021, China | | Wang Jiaonan | National Institute of Environmental Health, Chinese Center for Disease Control and Prevention, Beijing 100021, China | | Cao Zhaojin | National Institute of Environmental Health, Chinese Center for Disease Control and Prevention, Beijing 100021, China | | Wu Xianbo | Department of Epidemiology, School of Public Health, Southern Medical University, Guangzhou 510515, China | | Shi Xiaoming | National Institute of Environmental Health, Chinese Center for Disease Control and Prevention, Beijing 100021, China | shixm@chinacdc.cn | Mao Chen | Department of Epidemiology, School of Public Health, Southern Medical University, Guangzhou 510515, China | maochen9@smu.edu.cn |
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Abstract: |
目的 探讨中国长寿地区≥ 65岁老年人估算肾小球滤过率(eGFR)与全因死亡率之间的关系。方法 数据来源于"中国老年健康影响因素跟踪调查"子队列-"老年健康生物标志物队列研究",本研究共纳入2012年至2017/2018年的1 802名研究对象。根据eGFR水平将老年人分为4组:肾功能中-重度损伤组[<45 ml·min-1·(1.73 m2)-1]、肾功能轻-中度损伤组[45~ml·min-1·(1.73 m2)-1]、肾功能轻度损伤组[60~ml·min-1·(1.73 m2)-1]、肾功能正常组[≥ 90 ml·min-1·(1.73 m2)-1]。采用Cox比例风险模型评估eGFR水平与死亡风险之间的关联。结果 经6年随访共计852人死亡,死亡率为47.3%。多因素Cox回归分析结果显示,eGFR水平与老年人全因死亡风险呈负相关[eGFR水平每升高1 ml·min-1·(1.73 m2)-1,老年人死亡HR=0.993,95%CI:0.989~0.997,P=0.001];相较于肾功能正常组,肾功能中-重度损伤组、轻-中度损伤组及轻度损伤组老年人死亡HR值(95%CI)分别为1.690(1.224~2.332,P=0.001)、1.312(0.978~1.758,P=0.070)、1.349(1.047~1.737,P=0.020)(趋势检验P<0.001)。结论 eGFR下降与中国长寿地区老年人群的高死亡风险相关。 |
English Abstract: |
Objective To investigate the association between estimated glomerular filtration rate (eGFR) and all-cause mortality in the elderly aged 65 years and older in longevity areas in China. Methods Data used in this study were obtained from Healthy Aging and Biomarkers Cohort Study, a sub-cohort of the Chinese Longitudinal Healthy Longevity Survey, 1 802 elderly adults were collected in the study during 2012-2017/2018. In this study, the elderly were classified into 4 groups, moderate-to-severe group[<45 ml·min-1·(1.73 m2)-1], mild-to-moderate group[45-ml·min-1·(1.73 m2)-1], mild group[60-ml·min-1·(1.73 m2)-1] and normal group[ ≥ 90 ml·min-1·(1.73 m2)-1] according to their eGFR levels. Results After 6 years of follow-up, 852 participants died, with a mortality rate of 47.3%. Multivariate Cox regression analysis showed that the levels of eGFR were negatively correlated with all-cause mortality risk in the elderly (the HR of elderly was 0.993 and the 95%CI was 0.989-0.997 for every unit of eGFR increased, P=0.001), while compared with the group with normal eGFR, the HRs (95%CI) of the elderly in the moderate-to-severe group, mild-to-moderate group, and mild group were 1.690 (1.224-2.332, P=0.001), 1.312 (0.978-1.758, P=0.070), 1.349 (1.047-1.737, P=0.020) respectively[trend test P<0.001]. Conclusion The decrease in eGFR was associated with higher mortality risk among the elderly in longevity areas in China. |
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