| 陈清,赵峰,黄清湄,吕跃斌,钟文芳,周锦辉,李志浩,曲英莉,刘玲,刘迎春,王蛟男,曹兆进,吴娴波,施小明,毛琛.中国8个长寿地区65岁及以上老年人肾小球滤过率对全因死亡风险的影响[J].Chinese journal of Epidemiology,2020,41(1):36-41 |
| 中国8个长寿地区65岁及以上老年人肾小球滤过率对全因死亡风险的影响 |
| Effects of estimated glomerular filtration rate on all-cause mortality in the elderly aged 65 years and older in 8 longevity areas in China |
| Received:June 13, 2019 |
| DOI：10.3760/cma.j.issn.0254-6450.2020.01.008 |
| KeyWord: 肾小球滤过率 全因死亡 老年人 |
| English Key Word: Glomerular filtration rate All-cause mortality Elderly |
| FundProject:国家自然科学基金（81973109，81872707，81573247）；国家重点研发计划（2018YFC2000400） |
| Author Name | Affiliation | E-mail | | Chen Qing | Department of Epidemiology, School of Public Health, Southern Medical University, Guangzhou 510515, China | | | Zhao Feng | National Institute of Environmental Health, Chinese Center for Disease Control and Prevention, Beijing 100021, China | | | Huang Qingmei | Department of Epidemiology, School of Public Health, Southern Medical University, Guangzhou 510515, China | | | Lyu Yuebin | National Institute of Environmental Health, Chinese Center for Disease Control and Prevention, Beijing 100021, China | | | Zhong Wenfang | Department of Epidemiology, School of Public Health, Southern Medical University, Guangzhou 510515, China | | | Zhou Jinhui | National Institute of Environmental Health, Chinese Center for Disease Control and Prevention, Beijing 100021, China | | | Li Zhihao | Department of Epidemiology, School of Public Health, Southern Medical University, Guangzhou 510515, China | | | Qu Yingli | National Institute of Environmental Health, Chinese Center for Disease Control and Prevention, Beijing 100021, China | | | Liu Ling | National Institute of Environmental Health, Chinese Center for Disease Control and Prevention, Beijing 100021, China | | | Liu Yingchun | National Institute of Environmental Health, Chinese Center for Disease Control and Prevention, Beijing 100021, China | | | Wang Jiaonan | National Institute of Environmental Health, Chinese Center for Disease Control and Prevention, Beijing 100021, China | | | Cao Zhaojin | National Institute of Environmental Health, Chinese Center for Disease Control and Prevention, Beijing 100021, China | | | Wu Xianbo | Department of Epidemiology, School of Public Health, Southern Medical University, Guangzhou 510515, China | | | Shi Xiaoming | National Institute of Environmental Health, Chinese Center for Disease Control and Prevention, Beijing 100021, China | shixm@chinacdc.cn | | Mao Chen | Department of Epidemiology, School of Public Health, Southern Medical University, Guangzhou 510515, China | maochen9@smu.edu.cn |
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| Abstract: |
| 目的 探讨中国长寿地区≥ 65岁老年人估算肾小球滤过率（eGFR）与全因死亡率之间的关系。方法 数据来源于"中国老年健康影响因素跟踪调查"子队列-"老年健康生物标志物队列研究"，本研究共纳入2012年至2017/2018年的1 802名研究对象。根据eGFR水平将老年人分为4组：肾功能中-重度损伤组[<45 ml·min-1·（1.73 m2）-1]、肾功能轻-中度损伤组[45~ml·min-1·（1.73 m2）-1]、肾功能轻度损伤组[60~ml·min-1·（1.73 m2）-1]、肾功能正常组[≥ 90 ml·min-1·（1.73 m2）-1]。采用Cox比例风险模型评估eGFR水平与死亡风险之间的关联。结果 经6年随访共计852人死亡，死亡率为47.3%。多因素Cox回归分析结果显示，eGFR水平与老年人全因死亡风险呈负相关[eGFR水平每升高1 ml·min-1·（1.73 m2）-1，老年人死亡HR=0.993，95%CI：0.989~0.997，P=0.001]；相较于肾功能正常组，肾功能中-重度损伤组、轻-中度损伤组及轻度损伤组老年人死亡HR值（95%CI）分别为1.690（1.224~2.332，P=0.001）、1.312（0.978~1.758，P=0.070）、1.349（1.047~1.737，P=0.020）（趋势检验P<0.001）。结论 eGFR下降与中国长寿地区老年人群的高死亡风险相关。 |
| English Abstract: |
| Objective To investigate the association between estimated glomerular filtration rate (eGFR) and all-cause mortality in the elderly aged 65 years and older in longevity areas in China. Methods Data used in this study were obtained from Healthy Aging and Biomarkers Cohort Study, a sub-cohort of the Chinese Longitudinal Healthy Longevity Survey, 1 802 elderly adults were collected in the study during 2012-2017/2018. In this study, the elderly were classified into 4 groups, moderate-to-severe group[<45 ml·min-1·(1.73 m2)-1], mild-to-moderate group[45-ml·min-1·(1.73 m2)-1], mild group[60-ml·min-1·(1.73 m2)-1] and normal group[ ≥ 90 ml·min-1·(1.73 m2)-1] according to their eGFR levels. Results After 6 years of follow-up, 852 participants died, with a mortality rate of 47.3%. Multivariate Cox regression analysis showed that the levels of eGFR were negatively correlated with all-cause mortality risk in the elderly (the HR of elderly was 0.993 and the 95%CI was 0.989-0.997 for every unit of eGFR increased, P=0.001), while compared with the group with normal eGFR, the HRs (95%CI) of the elderly in the moderate-to-severe group, mild-to-moderate group, and mild group were 1.690 (1.224-2.332, P=0.001), 1.312 (0.978-1.758, P=0.070), 1.349 (1.047-1.737, P=0.020) respectively[trend test P<0.001]. Conclusion The decrease in eGFR was associated with higher mortality risk among the elderly in longevity areas in China. |
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